Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Angiotensin II receptor | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0609 | 0.0702 | 0.062 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0317 | 0.0088 | 0.3269 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0609 | 0.0702 | 0.062 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0609 | 0.0702 | 0.062 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0403 | 0.0269 | 0.0148 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0609 | 0.0702 | 0.062 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0403 | 0.0269 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0609 | 0.0702 | 0.062 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0403 | 0.0269 | 1 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0403 | 0.0269 | 0.0182 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.1032 | 0.1591 | 0.5 |
Schistosoma mansoni | glutamate receptor kainate | 0.0403 | 0.0269 | 0.0148 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.3599 | 0.6985 | 0.6958 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0296 | 0.0044 | 0.5 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0403 | 0.0269 | 0.0148 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0403 | 0.0269 | 0.0182 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0403 | 0.0269 | 0.0182 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.1032 | 0.1591 | 0.5 |
Echinococcus multilocularis | Ribosomal protein S1, RNA binding domain | 0.0403 | 0.0269 | 0.0182 |
Schistosoma mansoni | glutamate receptor kainate | 0.0403 | 0.0269 | 0.0148 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0609 | 0.0702 | 0.062 |
Echinococcus multilocularis | NMDA receptor | 0.0403 | 0.0269 | 0.0182 |
Schistosoma mansoni | glutamate receptor kainate | 0.0403 | 0.0269 | 0.0148 |
Schistosoma mansoni | glutamate receptor NMDA | 0.4208 | 0.8265 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.1435 | 0.2437 | 0.237 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0403 | 0.0269 | 0.0182 |
Echinococcus granulosus | glutamate receptor 2 | 0.0609 | 0.0702 | 0.062 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.1032 | 0.1591 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.5033 | 1 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0403 | 0.0269 | 0.0182 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0609 | 0.0702 | 0.062 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0403 | 0.0269 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0403 | 0.0269 | 0.0148 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0609 | 0.0702 | 0.062 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0296 | 0.0044 | 0.5 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0403 | 0.0269 | 0.0148 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0609 | 0.0702 | 0.062 |
Chlamydia trachomatis | glutamine binding protein | 0.1032 | 0.1591 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.1032 | 0.1591 | 0.5 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0403 | 0.0269 | 0.0182 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0403 | 0.0269 | 1 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0403 | 0.0269 | 0.0182 |
Schistosoma mansoni | hypothetical protein | 0.0403 | 0.0269 | 0.0148 |
Echinococcus granulosus | Ribosomal protein S1 RNA binding domain | 0.0403 | 0.0269 | 0.0182 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0403 | 0.0269 | 0.0182 |
Echinococcus granulosus | glutamate receptor NMDA | 0.3599 | 0.6985 | 0.6958 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.3805 | 0.7419 | 0.7396 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.1032 | 0.1591 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.3805 | 0.7419 | 0.7396 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1 uM | Compound was tested for inhibition of Angiotensin II receptor in rabbit aorta binding assay | ChEMBL. | No reference |
IC50 (binding) | = 1 uM | Compound was tested for inhibition of Angiotensin II receptor in rabbit aorta binding assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.