Detailed information for compound 1353885

Basic information

Technical information
  • TDR Targets ID: 1353885
  • Name: 2-[[4-(4-fluorophenyl)sulfonyl-2-(4-methylphe nyl)-1,3-oxazol-5-yl]sulfanyl]-N-(oxolan-2-yl methyl)acetamide
  • MW: 490.568 | Formula: C23H23FN2O5S2
  • H donors: 1 H acceptors: 4 LogP: 4.19 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CSc1oc(nc1S(=O)(=O)c1ccc(cc1)F)c1ccc(cc1)C)NCC1CCCO1
  • InChi: 1S/C23H23FN2O5S2/c1-15-4-6-16(7-5-15)21-26-22(33(28,29)19-10-8-17(24)9-11-19)23(31-21)32-14-20(27)25-13-18-3-2-12-30-18/h4-11,18H,2-3,12-14H2,1H3,(H,25,27)
  • InChiKey: RTIMETTXXGMVEL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[4-(4-fluorophenyl)sulfonyl-2-(4-methylphenyl)oxazol-5-yl]sulfanyl-N-(tetrahydrofuran-2-ylmethyl)acetamide
  • 2-[[4-(4-fluorophenyl)sulfonyl-2-(4-methylphenyl)-5-oxazolyl]thio]-N-(2-tetrahydrofuranylmethyl)acetamide
  • 2-[[4-(4-fluorophenyl)sulfonyl-2-(4-methylphenyl)oxazol-5-yl]thio]-N-(tetrahydrofurfuryl)acetamide
  • 2-[[4-(4-fluorophenyl)sulfonyl-2-(4-methylphenyl)-1,3-oxazol-5-yl]sulfanyl]-N-(oxolan-2-ylmethyl)ethanamide
  • 2-{[4-[(4-fluorophenyl)sulfonyl]-2-(4-methylphenyl)-1,3-oxazol-5-yl]thio}-N-(tetrahydrofuran-2-ylmethyl)acetamide
  • MLS000086665
  • SMR000022712

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0186 0.626 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0617 0.0766
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.072 0.0947
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0186 0.626 1
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.3545 0.5898
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.018 0.0159
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0028 0.0306 0.0424
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.018 0.0159
Onchocerca volvulus 0.0028 0.0306 0.0128
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.497 1
Onchocerca volvulus 0.0036 0.0617 0.0445
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.018 0.0141
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0567 0.0808
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.1421 0.0043
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0186 0.626 0.5659
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0975 0.1393
Mycobacterium ulcerans hypothetical protein 0.0028 0.0306 0.0424
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3545 1
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0306 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.018 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.018 0.0141
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0129 0.4103 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.8697 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.3545 1
Schistosoma mansoni thyroid hormone receptor 0.0176 0.5886 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0186 0.626 0.5659
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.018 0.0141
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0975 0.1393
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.018 0.0159
Entamoeba histolytica hypothetical protein 0.0039 0.072 0.0696
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.018 0.0141
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.018 0.0159
Brugia malayi hypothetical protein 0.0039 0.072 0.0767
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0306 0.0287
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0975 0.1393
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3545 0.2509
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0186 0.626 0.7184
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.018 0.0141
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0975 0.1393
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.0159
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0043 0.0104
Onchocerca volvulus Matrilysin homolog 0.0039 0.071 0.054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0617 0.0766
Brugia malayi nuclear hormone receptor 0.0024 0.018 0.0141
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0021 0.0058 0.0142
Trichomonas vaginalis set domain proteins, putative 0.0286 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0975 0.1061
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0186 0.626 0.7179
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0306 0.0287
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3545 0.2509
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.0159
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.497 0.8394
Entamoeba histolytica hypothetical protein 0.0039 0.072 0.0696
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.3545 0.7026
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3545 0.2509
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0186 0.626 1
Schistosoma mansoni kinase 0.0058 0.144 0.2208
Schistosoma mansoni thyroid hormone receptor 0.0176 0.5886 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0975 0.1077
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0306 0.0424
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0028 0.0306 0.0424
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.018 0.0141
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.0159
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0057 0.1421 0.0043
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0043 0.5
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0186 0.626 0.5659
Loa Loa (eye worm) matrixin family protein 0.0039 0.071 0.0772
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3545 0.2509
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.0159
Schistosoma mansoni hypothetical protein 0.0039 0.072 0.0947
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0306 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.072 0.0947
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0063 0.1635 0.3037
Entamoeba histolytica hypothetical protein 0.0039 0.072 0.0696
Echinococcus multilocularis thyroid hormone receptor alpha 0.0176 0.5886 1
Brugia malayi Matrixin family protein 0.0042 0.0841 0.0906
Brugia malayi Hemopexin family protein 0.0025 0.0189 0.0151
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0186 0.626 0.5659
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0617 0.0766
Schistosoma mansoni hypothetical protein 0.0025 0.0189 0.0015
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3545 0.2509
Brugia malayi steroid hormone receptor 0.0024 0.018 0.0141
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.3545 0.5898
Loa Loa (eye worm) hypothetical protein 0.0028 0.0306 0.0304
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0306 0.0424
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.018 0.0141
Loa Loa (eye worm) matrixin family protein 0.0042 0.0841 0.0922
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.018 0.0159
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0041 0.0813 0.1108
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.0159
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0306 0.0745
Schistosoma mansoni hypothetical protein 0.0152 0.497 0.8394
Onchocerca volvulus 0.0025 0.0189 0.0009
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0043 0.5
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.3545 0.4037
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0186 0.626 0.5659
Brugia malayi Pre-SET motif family protein 0.0036 0.0617 0.0647
Leishmania major hypothetical protein, conserved 0.0057 0.1421 0.3441
Mycobacterium ulcerans hydrolase 0.0021 0.0058 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.018 0.0159
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.018 0.0141
Trypanosoma brucei polo-like protein kinase 0.0114 0.3545 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3545 0.2509
Onchocerca volvulus Matrix metalloproteinase homolog 0.0039 0.071 0.054
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0063 0.1635 0.2549
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.018 0.0159
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0617 0.0766
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.072 0.1128
Onchocerca volvulus 0.0186 0.626 0.6191
Loa Loa (eye worm) hypothetical protein 0.0036 0.0617 0.0664
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0975 0.1659
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0028 0.0306 0.0745
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.0159
Brugia malayi nuclear receptor NHR-88 0.0024 0.018 0.0141
Entamoeba histolytica hypothetical protein 0.0039 0.072 0.0696
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.0159
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0975 0.1659
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0617 0.0766
Plasmodium vivax SET domain protein, putative 0.0036 0.0617 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0028 0.0306 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.018 0.0141
Brugia malayi ecdysteroid receptor 0.0024 0.018 0.0141
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.018 0.0159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0975 0.1393
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0028 0.0306 0.0424
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0028 0.0306 0.0424
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.018 0.0141
Loa Loa (eye worm) hypothetical protein 0.0028 0.0306 0.0304
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.018 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.018 0.0141
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.018 0.0141
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3545 0.2509
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0617 0.0766
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.3545 0.5441
Brugia malayi Pre-SET motif family protein 0.0251 0.8697 1
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0186 0.626 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.3545 0.3427
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0617 0.5
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.3545 0.4047
Mycobacterium ulcerans acyl-CoA synthetase 0.0028 0.0306 0.0424
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0186 0.626 0.5659
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0617 0.0912
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.018 0.0141
Loa Loa (eye worm) hypothetical protein 0.0028 0.0306 0.0304
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3545 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0018
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.018 0.0141

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0071 um PUBCHEM_BIOASSAY: Concentration Response Confirmation Assay for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) [Related pubchem assays: 1469 ] ChEMBL. No reference
Potency (functional) = 0.1259 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 18.8876 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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