Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | musashi | 0.0033 | 0.0291 | 0.2772 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.028 | 0.2674 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0291 | 0.2772 |
Brugia malayi | RNA binding protein | 0.0076 | 0.1048 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0291 | 0.2772 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0291 | 0.2772 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0291 | 0.2772 |
Onchocerca volvulus | 0.0033 | 0.0291 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1048 | 1 |
Onchocerca volvulus | 0.0033 | 0.0291 | 0.5 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.1048 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0507 | 0.2851 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1048 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0507 | 0.4833 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.1048 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0507 | 0.2851 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.1048 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.003 | 0.0285 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1048 | 1 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0291 | 0.2561 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0507 | 0.2851 |
Echinococcus granulosus | lamin | 0.0033 | 0.0291 | 0.2772 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0291 | 0.2561 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1048 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0507 | 0.4833 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.1048 | 1 |
Treponema pallidum | licC protein (licC) | 0.0109 | 0.1612 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0596 | 1 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.1048 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0109 | 0.1612 | 0.5 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0291 | 0.2772 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.0596 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.1048 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0507 | 0.4833 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1048 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0507 | 0.4833 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.0596 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.1048 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0291 | 0.2772 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0507 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0291 | 0.2772 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0507 | 0.4833 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0089 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.9341 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.