Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0033 | 0.0291 | 0.5 | |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.1048 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1048 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.1048 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1048 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0507 | 0.2851 |
Treponema pallidum | licC protein (licC) | 0.0109 | 0.1612 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0507 | 0.4682 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0291 | 0.2772 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0507 | 0.4833 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0291 | 0.2561 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.0596 | 1 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0507 | 0.4833 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0109 | 0.1612 | 0.5 |
Echinococcus granulosus | lamin | 0.0033 | 0.0291 | 0.2772 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0507 | 0.4833 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0507 | 0.4833 |
Onchocerca volvulus | 0.0033 | 0.0291 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1048 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.028 | 0.2674 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.1048 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0291 | 0.2772 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0507 | 0.2851 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.1048 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0291 | 0.2561 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1048 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0507 | 0.4833 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.003 | 0.0285 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0291 | 0.2772 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0291 | 0.2772 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0507 | 0.2851 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.1048 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.1048 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.1048 | 1 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0291 | 0.2772 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0291 | 0.2772 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0291 | 0.2772 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.1048 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0291 | 0.2772 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.0596 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0596 | 1 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.1048 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0089 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.9341 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.