Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.2792 | 0.6177 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1149 | 0.2441 | 0.3951 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.2792 | 0.6177 | 1 |
Brugia malayi | Lipocalin / cytosolic fatty-acid binding protein family protein | 0.0503 | 0.0971 | 0.1572 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1149 | 0.2441 | 0.3951 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.131 | 0.2806 | 1 |
Treponema pallidum | licC protein (licC) | 0.0451 | 0.0853 | 0.5 |
Echinococcus multilocularis | protein patched | 0.1149 | 0.2441 | 0.3951 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.131 | 0.2806 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1149 | 0.2441 | 0.3951 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.131 | 0.2806 | 0.5 |
Brugia malayi | CHE-14 protein | 0.1149 | 0.2441 | 0.3951 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.2792 | 0.6177 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.1149 | 0.2441 | 0.3951 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.2792 | 0.6177 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.1149 | 0.2441 | 0.3951 |
Schistosoma mansoni | patched 1 | 0.1149 | 0.2441 | 0.3951 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.2792 | 0.6177 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2792 | 0.6177 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.2792 | 0.6177 | 0.5821 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.2792 | 0.6177 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.4472 | 1 | 0.5 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1149 | 0.2441 | 0.3951 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.2792 | 0.6177 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1149 | 0.2441 | 0.3951 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.4472 | 1 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0451 | 0.0853 | 0.5 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.4472 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.2792 | 0.6177 | 0.5 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1149 | 0.2441 | 0.3951 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1149 | 0.2441 | 0.3951 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.131 | 0.2806 | 1 |
Loa Loa (eye worm) | lipocalin/cytosolic fatty-acid binding protein family protein | 0.0503 | 0.0971 | 0.1572 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0586 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.