Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.2792 | 0.6177 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1149 | 0.2441 | 0.3951 |
Brugia malayi | Lipocalin / cytosolic fatty-acid binding protein family protein | 0.0503 | 0.0971 | 0.1572 |
Loa Loa (eye worm) | lipocalin/cytosolic fatty-acid binding protein family protein | 0.0503 | 0.0971 | 0.1572 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.1149 | 0.2441 | 0.3951 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.1149 | 0.2441 | 0.3951 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.131 | 0.2806 | 0.5 |
Echinococcus multilocularis | protein patched | 0.1149 | 0.2441 | 0.3951 |
Brugia malayi | CHE-14 protein | 0.1149 | 0.2441 | 0.3951 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.1149 | 0.2441 | 0.3951 |
Echinococcus granulosus | Protein patched homolog 1 | 0.1149 | 0.2441 | 0.3951 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.1149 | 0.2441 | 0.3951 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.1149 | 0.2441 | 0.3951 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.4472 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.131 | 0.2806 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.131 | 0.2806 | 1 |
Schistosoma mansoni | patched 1 | 0.1149 | 0.2441 | 0.3951 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.2792 | 0.6177 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.131 | 0.2806 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0451 | 0.0853 | 0.5 |
Treponema pallidum | licC protein (licC) | 0.0451 | 0.0853 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.2792 | 0.6177 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.1149 | 0.2441 | 0.3951 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.4472 | 1 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.2792 | 0.6177 | 0.5 |
Echinococcus multilocularis | protein dispatched 1 | 0.1149 | 0.2441 | 0.3951 |
Loa Loa (eye worm) | hypothetical protein | 0.2792 | 0.6177 | 1 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.4472 | 1 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.2792 | 0.6177 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.2792 | 0.6177 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.2792 | 0.6177 | 1 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.2792 | 0.6177 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.2792 | 0.6177 | 0.5821 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0586 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.