Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | hydroxyprostaglandin dehydrogenase 15-(NAD) | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxyprostaglandin dehydrogenase 15-(NAD) | 266 aa | 216 aa | 22.2 % |
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 1 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MG, Family M24 | 0.0055 | 0.6531 | 0.9034 |
Leishmania major | methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 | 0.0058 | 0.7229 | 0.7229 |
Wolbachia endosymbiont of Brugia malayi | methionine aminopeptidase | 0.0039 | 0.3716 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Plasmodium vivax | methionine aminopeptidase 2, putative | 0.0055 | 0.6531 | 0.9034 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Toxoplasma gondii | methionine aminopeptidase | 0.0039 | 0.3716 | 0.3716 |
Plasmodium falciparum | methionine aminopeptidase 2 | 0.0055 | 0.6531 | 0.9034 |
Trypanosoma brucei | metallo- peptidase, Clan MG, Family M24 | 0.0058 | 0.7229 | 1 |
Brugia malayi | Methionine aminopeptidase protein type I | 0.0058 | 0.7229 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 2 | 0.0055 | 0.6531 | 0.4479 |
Plasmodium falciparum | methionine aminopeptidase 1b, putative | 0.0058 | 0.7229 | 1 |
Toxoplasma gondii | methionine aminopeptidase | 0.0058 | 0.7229 | 0.7229 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 1 | 1 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0055 | 0.6531 | 0.5 |
Plasmodium vivax | methionine aminopeptidase 1a, putative | 0.0039 | 0.3716 | 0.5141 |
Loa Loa (eye worm) | methionine aminopeptidase type I | 0.0058 | 0.7229 | 1 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) | 0.0039 | 0.3716 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0055 | 0.6531 | 0.9034 |
Chlamydia trachomatis | methionine aminopeptidase | 0.0039 | 0.3716 | 0.5 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0055 | 0.6531 | 0.5 |
Echinococcus granulosus | methionyl aminopeptidase 1 M24 family | 0.0058 | 0.7229 | 0.2013 |
Trypanosoma cruzi | metallo-peptidase, Clan MG, Family M24 | 0.0055 | 0.6531 | 0.9034 |
Plasmodium vivax | methionine aminopeptidase 1b, putative | 0.0058 | 0.7229 | 1 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0058 | 0.7229 | 1 |
Treponema pallidum | methionine aminopeptidase (map) | 0.0039 | 0.3716 | 0.5 |
Trypanosoma brucei | methionine aminopeptidase, putative | 0.0058 | 0.7229 | 1 |
Entamoeba histolytica | methionine aminopeptidase, putative | 0.0055 | 0.6531 | 0.5 |
Trypanosoma cruzi | metallo- peptidase, Clan MG, Family M24 | 0.0058 | 0.7229 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Echinococcus multilocularis | methionyl aminopeptidase 1 (M24 family) | 0.0058 | 0.7229 | 0.559 |
Schistosoma mansoni | methionyl aminopeptidase 2 (M24 family) | 0.0055 | 0.6531 | 0.4479 |
Toxoplasma gondii | methionine aminopeptidase, type i, putative | 0.0039 | 0.3716 | 0.3716 |
Plasmodium falciparum | methionine aminopeptidase 1a, putative | 0.0039 | 0.3716 | 0.5141 |
Giardia lamblia | Methionine aminopeptidase | 0.0055 | 0.6531 | 0.5 |
Leishmania major | methionine aminopeptidase 2, putative | 0.0055 | 0.6531 | 0.6531 |
Mycobacterium leprae | PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) | 0.0039 | 0.3716 | 0.5 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0055 | 0.6531 | 0.5 |
Trichomonas vaginalis | Clan MG, familly M24, aminopeptidase P-like metallopeptidase | 0.0055 | 0.6531 | 0.5 |
Toxoplasma gondii | methionine aminopeptidase 2, putative | 0.0055 | 0.6531 | 0.6531 |
Onchocerca volvulus | Methionine aminopeptidase 2 homolog | 0.0055 | 0.6531 | 0.5 |
Trypanosoma brucei | methionine aminopeptidase, type I, putative | 0.0058 | 0.7229 | 1 |
Trypanosoma brucei | methionine aminopeptidase 2, putative | 0.0055 | 0.6531 | 0.9034 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.7783 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 3.1623 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.