Detailed information for compound 1362525

Basic information

Technical information
  • TDR Targets ID: 1362525
  • Name: ethyl 6-methyl-4-oxoquinolizine-3-carboxylate
  • MW: 231.247 | Formula: C13H13NO3
  • H donors: 0 H acceptors: 2 LogP: 2.13 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ccc2n(c1=O)c(C)ccc2
  • InChi: 1S/C13H13NO3/c1-3-17-13(16)11-8-7-10-6-4-5-9(2)14(10)12(11)15/h4-8H,3H2,1-2H3
  • InChiKey: DQAYZVOYUWQVJM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 6-methyl-4-oxo-quinolizine-3-carboxylate
  • 6-methyl-4-oxo-3-quinolizinecarboxylic acid ethyl ester
  • 4-keto-6-methyl-quinolizine-3-carboxylic acid ethyl ester
  • AC-907/34130015
  • ZINC00343593
  • MLS000538226
  • SMR000162695
  • ethyl 6-methyl-4-oxo-4H-quinolizine-3-carboxylate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens snurportin 1 No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens RAN, member RAS oncogene family No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus muscleblind protein 0.018 0.4472 0.4472
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0155 0.3736 0.8869
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0165 0.4019 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0075 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0086 0.1759 0.0954
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0068 0.1238 0.2767
Loa Loa (eye worm) GMP reductase 0.0068 0.1238 0.1238
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0266 0.0661
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0155 0.3736 1
Loa Loa (eye worm) hypothetical protein 0.018 0.4472 0.4472
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0068 0.1238 0.2767
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0999 0.0999
Leishmania major importin beta-1 subunit, putative 0.0028 0.0075 0.0187
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0075 1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0266 0.0266
Trypanosoma cruzi GMP reductase 0.0165 0.4019 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0266 0.0711
Echinococcus granulosus importin subunit beta 1 0.0035 0.0266 0.0266
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0165 0.4019 1
Schistosoma mansoni importin beta-1 0.0035 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.0041 0.0449 0.0449
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0999 0.2234
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0165 0.4019 0.4019
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0075 0.0187
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0165 0.4019 0.4019
Plasmodium falciparum importin beta, putative 0.0035 0.0266 0.0711
Loa Loa (eye worm) IMP dehydrogenase 1 0.0165 0.4019 0.4019
Loa Loa (eye worm) hypothetical protein 0.0035 0.0266 0.0266
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0165 0.4019 1
Brugia malayi Importin beta-1 subunit 0.0035 0.0266 0.0594
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0 0.5
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0165 0.4019 0.5
Leishmania major guanosine monophosphate reductase 0.0165 0.4019 1
Echinococcus multilocularis muscleblind protein 0.018 0.4472 0.4472
Schistosoma mansoni hypothetical protein 0.0041 0.0449 0.0449
Loa Loa (eye worm) hypothetical protein 0.018 0.4472 0.4472
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 1 1
Echinococcus multilocularis muscleblind protein 1 0.018 0.4472 0.4472
Toxoplasma gondii IMP dehydrogenas 0.0165 0.4019 1
Trypanosoma brucei GMP reductase 0.0165 0.4019 1
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0165 0.4019 0.4019
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0999 0.2234
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0075 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0266 0.0661
Brugia malayi GMP reductase 0.0068 0.1238 0.2767
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0449 0.1003
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0165 0.4019 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0999 0.0999
Trypanosoma cruzi GMP reductase 0.0165 0.4019 1
Onchocerca volvulus Putative GMP reductase 0.0068 0.1238 0.5
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0165 0.4019 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0165 0.4019 1
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0155 0.3736 1
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0266 0.0661
Schistosoma mansoni hypothetical protein 0.0372 1 1
Leishmania major inosine-5-monophosphate dehydrogenase 0.0165 0.4019 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0165 0.4019 1
Brugia malayi Muscleblind-like protein 0.018 0.4472 1
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0165 0.4019 0.8988
Echinococcus multilocularis snurportin 1 0.0372 1 1
Entamoeba histolytica hypothetical protein 0.0028 0.0075 1
Brugia malayi RNA, U transporter 1 0.0099 0.2121 0.4742

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (binding) 14.1254 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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