Detailed information for compound 1364582

Basic information

Technical information
  • TDR Targets ID: 1364582
  • Name: 2-[2-(phenylmethyl)phenoxy]acetic acid
  • MW: 242.27 | Formula: C15H14O3
  • H donors: 1 H acceptors: 2 LogP: 3.41 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)COc1ccccc1Cc1ccccc1
  • InChi: 1S/C15H14O3/c16-15(17)11-18-14-9-5-4-8-13(14)10-12-6-2-1-3-7-12/h1-9H,10-11H2,(H,16,17)
  • InChiKey: FNKKMCAPBFWQTQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-(benzyl)phenoxy]acetic acid
  • 2-[2-(phenylmethyl)phenoxy]ethanoic acid
  • MLS000054290
  • SMR000066215
  • STK325198
  • IDI1_006874
  • Oprea1_142805
  • Enamine_002527

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Histone deacetylase 1 0.0419 0.5659 1
Plasmodium vivax hypothetical protein, conserved 0.011 0.0906 0.1601
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3721 0.6575
Trypanosoma brucei histone deacetylase 2 0.0146 0.1454 0.257
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0906 0.1601
Schistosoma mansoni histone deacetylase 4 5 0.023 0.2752 0.4413
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.3721 0.6575
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0234 0.2806 0.4958
Mycobacterium ulcerans lipase LipD 0.011 0.0906 0.3376
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0154 0.1586 0.2803
Toxoplasma gondii histone deacetylase HDAC5 0.0146 0.1454 0.257
Leishmania major hypothetical protein, conserved 0.011 0.0906 0.1601
Schistosoma mansoni histone deacetylase 1 2 3 0.0146 0.1454 0.2332
Trichomonas vaginalis histone deacetylase, putative 0.0419 0.5659 1
Toxoplasma gondii aspartyl protease ASP1 0.0083 0.0489 0.0863
Toxoplasma gondii prolyl endopeptidase 0.0128 0.1184 0.2092
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0234 0.2806 0.4958
Trichomonas vaginalis histone deacetylase, putative 0.0419 0.5659 1
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0083 0.0489 0.0863
Mycobacterium leprae conserved hypothetical protein 0.011 0.0906 0.3376
Schistosoma mansoni histone deacetylase hda2 0.023 0.2752 0.4413
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.1418 0.1418
Echinococcus multilocularis histone deacetylase 7 0.023 0.2752 0.4863
Toxoplasma gondii histone deacetylase HDAC3 0.0419 0.5659 1
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0906 0.1601
Toxoplasma gondii hypothetical protein 0.0226 0.2684 0.4743
Loa Loa (eye worm) beta-lactamase 0.011 0.0906 0.1601
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0234 0.2806 0.4958
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0067 0.0107
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0154 0.1586 0.2803
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0234 0.2806 0.4958
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0067 0.0107
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0083 0.0489 0.0863
Schistosoma mansoni chromatin regulatory protein sir2 0.0234 0.2806 0.45
Mycobacterium ulcerans hypothetical protein 0.011 0.0906 0.3376
Mycobacterium tuberculosis Probable lipase LipD 0.011 0.0906 0.0906
Schistosoma mansoni chromatin regulatory protein sir2 0.0234 0.2806 0.45
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0906 0.1601
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0906 0.1453
Echinococcus multilocularis histone deacetylase 1 0.0419 0.5659 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0906 0.1601
Trichomonas vaginalis histone deacetylase, putative 0.0419 0.5659 1
Brugia malayi NAD-dependent deacetylase SIRT1 0.0154 0.1586 0.2803
Schistosoma mansoni chromatin regulatory protein sir2 0.0234 0.2806 0.45
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0067 0.0118
Trypanosoma cruzi histone deacetylase, putative 0.0146 0.1454 0.257
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.3721 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0906 0.1601
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.011 0.0906 0.1601
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0067 0.0118
Loa Loa (eye worm) hypothetical protein 0.011 0.0906 0.1601
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.3721 0.6575
Echinococcus multilocularis histone deacetylase 8 0.0146 0.1454 0.257
Echinococcus granulosus histone deacetylase 8 0.0146 0.1454 0.257
Plasmodium falciparum plasmepsin I 0.0083 0.0489 0.0863
Trypanosoma cruzi Peptide deformylase 2, putative 0.0086 0.0541 0.0956
Plasmodium falciparum histone deacetylase 2 0.023 0.2752 0.4863
Plasmodium falciparum histone deacetylase 1 0.0419 0.5659 1
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0083 0.0489 0.0863
Onchocerca volvulus Prolyl endopeptidase homolog 0.0128 0.1184 0.5068
Schistosoma mansoni histone deacetylase hda2 0.0146 0.1454 0.2332
Plasmodium falciparum plasmepsin X 0.0285 0.3588 0.6341
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0277 0.3472 0.6135
Loa Loa (eye worm) histone deacetylase 11 0.0146 0.1454 0.257
Trichomonas vaginalis histone deacetylase, putative 0.0419 0.5659 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3721 0.6575
Echinococcus multilocularis histone deacetylase 6 0.023 0.2752 0.4863
Plasmodium falciparum plasmepsin IV 0.0083 0.0489 0.0863
Plasmodium vivax aspartyl proteinase, putative 0.0083 0.0489 0.0863
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0234 0.2806 0.4958
Brugia malayi histone deacetylase 3 (HD3) 0.0419 0.5659 1
Trichomonas vaginalis histone deacetylase, putative 0.0419 0.5659 1
Echinococcus granulosus histone deacetylase 6 0.023 0.2752 0.4863
Chlamydia trachomatis peptide deformylase 0.0226 0.2684 0.5
Leishmania major polypeptide deformylase-like protein, putative 0.0086 0.0541 0.0956
Trichomonas vaginalis histone deacetylase, putative 0.0419 0.5659 1
Plasmodium falciparum plasmepsin II 0.0083 0.0489 0.0863
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.011 0.0906 0.0906
Loa Loa (eye worm) hypothetical protein 0.0085 0.0516 0.0912
Plasmodium vivax histone deacetylase, putative 0.0146 0.1454 0.257
Brugia malayi Histone deacetylase family protein 0.023 0.2752 0.4863
Leishmania major histone deacetylase, putative 0.023 0.2752 0.4863
Echinococcus multilocularis histone deacetylase 3 0.0419 0.5659 1
Trypanosoma cruzi prolyl endopeptidase 0.0128 0.1184 0.2092
Brugia malayi transcriptional regulator, Sir2 family protein 0.0234 0.2806 0.4958
Toxoplasma gondii histone deacetylase HDAC1 0.023 0.2752 0.4863
Trypanosoma brucei histone deacetylase 4 0.023 0.2752 0.4863
Entamoeba histolytica histone deacetylase, putative 0.0419 0.5659 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0419 0.5659 1
Loa Loa (eye worm) hypothetical protein 0.0154 0.1586 0.2803
Leishmania major histone deacetylase, putative 0.023 0.2752 0.4863
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0086 0.0541 0.0956
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0083 0.0489 0.0863
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0128 0.1184 0.2092
Mycobacterium ulcerans esterase/lipase LipP 0.011 0.0906 0.3376
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.011 0.0906 0.1453
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.1418 0.5283
Mycobacterium ulcerans peptide deformylase 0.0226 0.2684 1
Brugia malayi prolyl oligopeptidase family protein 0.0128 0.1184 0.2092
Plasmodium falciparum peptide deformylase 0.0226 0.2684 0.4743
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0154 0.1586 0.2803
Brugia malayi Histone deacetylase family protein 0.023 0.2752 0.4863
Toxoplasma gondii aspartyl protease ASP3 0.0285 0.3588 0.6341
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.1418 0.5283
Loa Loa (eye worm) histone deacetylase 7A 0.023 0.2752 0.4863
Toxoplasma gondii ABC1 family protein 0.011 0.0906 0.1601
Loa Loa (eye worm) hypothetical protein 0.0106 0.0847 0.1496
Echinococcus granulosus neuropeptides capa receptor 0.021 0.2439 0.4311
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0067 0.0118
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0154 0.1586 0.2803
Echinococcus granulosus histone deacetylase 6 0.023 0.2752 0.4863
Mycobacterium tuberculosis Conserved protein 0.011 0.0906 0.0906
Loa Loa (eye worm) histone deacetylase 1 0.0419 0.5659 1
Trypanosoma cruzi histone deacetylase, putative 0.023 0.2752 0.4863
Echinococcus granulosus chromatin regulatory protein sir2 0.0234 0.2806 0.4958
Mycobacterium leprae Probable lipase LipE 0.011 0.0906 0.3376
Plasmodium falciparum plasmepsin VI 0.0083 0.0489 0.0863
Mycobacterium tuberculosis Conserved protein 0.011 0.0906 0.0906
Echinococcus multilocularis histone deacetylase 6 0.023 0.2752 0.4863
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.3721 0.6575
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3721 0.6575
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3721 0.6575
Loa Loa (eye worm) hypothetical protein 0.0083 0.0489 0.0863
Echinococcus granulosus prolyl endopeptidase 0.0128 0.1184 0.2092
Loa Loa (eye worm) hypothetical protein 0.0085 0.0516 0.0912
Giardia lamblia Histone deacetylase 0.0419 0.5659 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.011 0.0906 0.0906
Leishmania major histone deacetylase, putative 0.0419 0.5659 1
Trypanosoma brucei prolyl endopeptidase 0.0128 0.1184 0.2092
Echinococcus granulosus histone deacetylase 6 0.023 0.2752 0.4863
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0083 0.0489 0.0784
Mycobacterium tuberculosis Probable lipase LipE 0.011 0.0906 0.0906
Echinococcus multilocularis beta LACTamase domain containing family member 0.011 0.0906 0.1601
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0419 0.5659 1
Trypanosoma cruzi histone deacetylase, putative 0.023 0.2752 0.4863
Trypanosoma brucei Peptide deformylase 2 0.0086 0.0541 0.0956
Giardia lamblia Hypothetical protein 0.0234 0.2806 0.4958
Echinococcus granulosus histone deacetylase 1 0.0419 0.5659 1
Brugia malayi histone deacetylase 1 (HD1) 0.0419 0.5659 1
Echinococcus granulosus histone deacetylase 7 0.023 0.2752 0.4863
Echinococcus multilocularis histone deacetylase 0.023 0.2752 0.4863
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0067 0.0118
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0234 0.2806 0.4958
Schistosoma mansoni cathepsin D (A01 family) 0.0457 0.6235 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3721 0.6575
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3721 0.6575
Loa Loa (eye worm) hypothetical protein 0.0146 0.1454 0.257
Trichomonas vaginalis D-aminoacylase, putative 0.011 0.0906 0.1601
Schistosoma mansoni histone deacetylase 4 5 0.023 0.2752 0.4413
Trypanosoma cruzi histone deacetylase, putative 0.023 0.2752 0.4863
Brugia malayi beta-lactamase family protein 0.011 0.0906 0.1601
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0128 0.1184 0.1899
Mycobacterium ulcerans beta-lactamase 0.011 0.0906 0.3376
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0128 0.1184 0.1899
Plasmodium vivax histone deacetylase 2, putative 0.023 0.2752 0.4863
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.011 0.0906 0.3376
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0226 0.2684 0.2684
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0906 0.1601
Toxoplasma gondii histone deacetylase HDAC2 0.0419 0.5659 1
Toxoplasma gondii histone deacetylase HDAC4 0.0146 0.1454 0.257
Echinococcus granulosus beta LACTamase domain containing family member 0.011 0.0906 0.1601
Echinococcus multilocularis neuropeptides capa receptor 0.021 0.2439 0.4311
Plasmodium vivax histone deacetylase, putative 0.023 0.2752 0.4863
Echinococcus multilocularis prolyl endopeptidase 0.0128 0.1184 0.2092
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0234 0.2806 0.4958
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0067 0.0118
Mycobacterium tuberculosis Probable conserved lipoprotein 0.011 0.0906 0.0906
Plasmodium vivax peptide deformylase, putative 0.0226 0.2684 0.4743
Leishmania major histone deacetylase, putative 0.0419 0.5659 1
Loa Loa (eye worm) transcriptional regulator 0.0234 0.2806 0.4958
Loa Loa (eye worm) hypothetical protein 0.0419 0.5659 1
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0226 0.2684 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0277 0.3472 0.5568
Loa Loa (eye worm) hypothetical protein 0.0128 0.1184 0.2092
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0067 0.0118
Mycobacterium tuberculosis Probable hydrolase 0.011 0.0906 0.0906
Trypanosoma cruzi histone deacetylase 1, putative 0.0419 0.5659 1
Leishmania major silent information regulator 2, putative 0.0234 0.2806 0.4958
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0234 0.2806 0.4958
Schistosoma mansoni cathepsin D (A01 family) 0.0457 0.6235 1
Trypanosoma cruzi hypothetical protein, conserved 0.011 0.0906 0.1601
Echinococcus granulosus histone deacetylase 0.023 0.2752 0.4863
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0154 0.1586 0.2803
Plasmodium falciparum plasmepsin IX 0.0285 0.3588 0.6341
Trypanosoma brucei Polypeptide deformylase 1 0.0086 0.0541 0.0956
Plasmodium vivax aspartyl protease, putative 0.0285 0.3588 0.6341
Mycobacterium tuberculosis Conserved protein 0.011 0.0906 0.0906
Echinococcus multilocularis chromatin regulatory protein sir2 0.0234 0.2806 0.4958
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.011 0.0906 0.1601
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3721 0.6575
Plasmodium vivax plasmepsin IV, putative 0.0083 0.0489 0.0863
Plasmodium vivax aspartyl protease, putative 0.0285 0.3588 0.6341
Loa Loa (eye worm) histone deacetylase 3 0.0419 0.5659 1
Trichomonas vaginalis esterase, putative 0.011 0.0906 0.1601
Plasmodium falciparum histone deacetylase, putative 0.023 0.2752 0.4863
Loa Loa (eye worm) hypothetical protein 0.011 0.0906 0.1601
Trypanosoma cruzi histone deacetylase, putative 0.0146 0.1454 0.257
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0086 0.0541 0.0956
Trypanosoma brucei histone deacetylase, putative 0.023 0.2752 0.4863
Brugia malayi beta-lactamase 0.011 0.0906 0.1601
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.3721 0.6575
Plasmodium vivax histone deacetylase 1, putative 0.0419 0.5659 1
Trypanosoma brucei histone deacetylase 3 0.023 0.2752 0.4863
Schistosoma mansoni histone deacetylase 0.0419 0.5659 0.9075
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0154 0.1586 0.2803
Trichomonas vaginalis penicillin-binding protein, putative 0.011 0.0906 0.1601
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0277 0.3472 0.6135
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0234 0.2806 0.4958
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0154 0.1586 0.2803
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0419 0.5659 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0154 0.1586 0.2544
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0067 0.0107
Echinococcus multilocularis histone deacetylase 6 0.023 0.2752 0.4863
Brugia malayi beta-lactamase family protein 0.011 0.0906 0.1601
Mycobacterium tuberculosis Probable esterase LipL 0.011 0.0906 0.0906
Loa Loa (eye worm) hypothetical protein 0.011 0.0906 0.1601
Brugia malayi histone deacetylase 11 0.0146 0.1454 0.257
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0115 0.0978 0.0978
Onchocerca volvulus Histone deacetylase 10 homolog 0.0146 0.1454 1
Schistosoma mansoni histone deacetylase 0.0419 0.5659 0.9075
Loa Loa (eye worm) histone deacetylase 0.023 0.2752 0.4863
Echinococcus granulosus histone deacetylase 3 0.0419 0.5659 1
Trypanosoma brucei histone deacetylase 1 0.0419 0.5659 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0906 0.1601
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0083 0.0489 0.0863
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0419 0.5659 1
Trypanosoma brucei hypothetical protein, conserved 0.011 0.0906 0.1601
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0226 0.2684 0.5
Trypanosoma cruzi Peptide deformylase 2, putative 0.0086 0.0541 0.0956

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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