TDR Targets

Basic information

Technical information

TDR Targets ID: 1367218
Name: N-cyclohexyl-N-[(5,6-dimethyl-4-oxo-3H-thieno [2,3-d]pyrimidin-2-yl)methyl]-2-methoxyacetam ide
MW: 363.474 | Formula: C18H25N3O3S
H donors: 1 H acceptors: 4 LogP: 3.32 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COCC(=O)N(C1CCCCC1)Cc1nc(O)c2c(n1)sc(c2C)C
InChi: 1S/C18H25N3O3S/c1-11-12(2)25-18-16(11)17(23)19-14(20-18)9-21(15(22)10-24-3)13-7-5-4-6-8-13/h13H,4-10H2,1-3H3,(H,19,20,23)
InChiKey: FUTHFTNTSQLYPM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-cyclohexyl-N-[(5,6-dimethyl-4-oxo-3H-thieno[2,3-d]pyrimidin-2-yl)methyl]-2-methoxy-acetamide
N-cyclohexyl-N-[(4-keto-5,6-dimethyl-3H-thieno[2,3-d]pyrimidin-2-yl)methyl]-2-methoxy-acetamide
N-cyclohexyl-N-[(5,6-dimethyl-4-oxo-3H-thieno[2,3-d]pyrimidin-2-yl)methyl]-2-methoxy-ethanamide
ASN 05811916
ZINC01358951
MLS000715360
SMR000275339

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	glucosidase, alpha	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Onchocerca volvulus		Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	alpha-glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	Lysosomal alpha-glucosidase precursor, putative	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	Glycosyl hydrolases family 31 protein	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Schistosoma japonicum	ko:K01187 alpha-glucosidase [EC3.2.1.20], putative	Get druggable targets OG5_127055	All targets in OG5_127055
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	hypothetical protein	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase	Get druggable targets OG5_127055	All targets in OG5_127055
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055
Candida albicans	cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose	Get druggable targets OG5_127055	All targets in OG5_127055
Echinococcus multilocularis	lysosomal alpha glucosidase	Get druggable targets OG5_127055	All targets in OG5_127055

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0318	0.0244	0.0146
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0318	0.0244	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0318	0.0244	0.0163
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0318	0.0244	0.0163
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0318	0.0244	0.0146
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0318	0.0244	0.0178
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0318	0.0244	0.0178
Brugia malayi	hypothetical protein	0.0318	0.0244	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Onchocerca volvulus		0.0318	0.0244	0.0407
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0318	0.0244	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1578	0.1751	0.2625
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0318	0.0244	0.0146
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.3542	0.4099	0.5
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.5121	0.5986	1
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0318	0.0244	0.0146
Onchocerca volvulus		0.0318	0.0244	0.0407
Onchocerca volvulus		0.0182	0.0082	0.0137
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0318	0.0244	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.5121	0.5986	1
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0318	0.0244	0.0163
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.8479	1	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0318	0.0244	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Trypanosoma cruzi	hypothetical protein, conserved	0.1578	0.1751	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0318	0.0244	0.0163
Schistosoma mansoni	protein tyrosine phosphatase	0.0318	0.0244	0.0178
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0318	0.0244	0.0146
Onchocerca volvulus	4.1 G protein, putative homolog	0.0318	0.0244	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0318	0.0244	0.0178
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0318	0.0244	0.0146
Onchocerca volvulus		0.0318	0.0244	0.0407
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0318	0.0244	0.0146
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.8479	1	1
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.5121	0.5986	0.5952
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.8479	1	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.5121	0.5986	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0318	0.0244	0.0146
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.5121	0.5986	1
Echinococcus multilocularis	hypothetical protein	0.0318	0.0244	0.0146
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0318	0.0244	0.0178
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Onchocerca volvulus		0.0318	0.0244	0.0407
Onchocerca volvulus		0.0318	0.0244	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Schistosoma mansoni	protein tyrosine phosphatase	0.0318	0.0244	0.0178
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0318	0.0244	0.0178
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0318	0.0244	0.0146
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0318	0.0244	0.0178
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0318	0.0244	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0318	0.0244	0.0178
Onchocerca volvulus		0.0318	0.0244	0.0407
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0197	0.0099	0.0017
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0318	0.0244	0.0146
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0318	0.0244	0.0163
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0318	0.0244	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0318	0.0244	0.0146
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.1578	0.1751	0.2625
Trypanosoma cruzi	hypothetical protein, conserved	0.1578	0.1751	1
Onchocerca volvulus		0.0318	0.0244	0.0407
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0318	0.0244	0.0163
Onchocerca volvulus		0.0318	0.0244	0.0407
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.1578	0.1751	1
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Leishmania major	hypothetical protein, conserved	0.1578	0.1751	1
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Onchocerca volvulus		0.0318	0.0244	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.8479	1	1
Onchocerca volvulus		0.0318	0.0244	0.0407
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0318	0.0244	0.0146
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0318	0.0244	0.0163
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.5121	0.5986	1
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0318	0.0244	0.0163
Brugia malayi	hypothetical protein	0.0318	0.0244	0.0163
Onchocerca volvulus		0.0318	0.0244	0.0407
Onchocerca volvulus		0.0318	0.0244	0.0407
Onchocerca volvulus		0.0318	0.0244	0.0407
Onchocerca volvulus		0.0318	0.0244	0.0407
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0318	0.0244	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0318	0.0244	0.0163
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0318	0.0244	0.0146
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.5121	0.5986	1
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.5121	0.5986	0.5
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0318	0.0244	0.0146
Onchocerca volvulus		0.0318	0.0244	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0318	0.0244	0.0163
Brugia malayi	hypothetical protein	0.0318	0.0244	0.0163
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0318	0.0244	0.0163
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0318	0.0244	0.0146
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0318	0.0244	0.0146
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0318	0.0244	0.0163
Onchocerca volvulus		0.0318	0.0244	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0318	0.0244	0.0146
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0318	0.0244	0.0146
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0318	0.0244	0.0146
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0318	0.0244	0.0178
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0318	0.0244	0.0146
Onchocerca volvulus		0.0318	0.0244	0.0407
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0197	0.0099	0.0017
Brugia malayi	hypothetical protein	0.0318	0.0244	0.0163
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Brugia malayi	Protein-tyrosine phosphatase 1	0.0318	0.0244	0.0163
Onchocerca volvulus		0.0318	0.0244	0.0407
Onchocerca volvulus		0.0318	0.0244	0.0407
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0318	0.0244	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0318	0.0244	0.0163
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0318	0.0244	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Brugia malayi	hypothetical protein	0.0318	0.0244	0.0163
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0318	0.0244	0.0163
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.5121	0.5986	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0318	0.0244	0.0146
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0318	0.0244	0.0146
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.5121	0.5986	0.5952
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0318	0.0244	0.0163
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0318	0.0244	0.0163
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Onchocerca volvulus		0.0318	0.0244	0.0407
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0318	0.0244	0.0146
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0318	0.0244	0.0146
Onchocerca volvulus		0.5121	0.5986	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0318	0.0244	0.0146
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0318	0.0244	0.0146
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0318	0.0244	0.0146
Brugia malayi	Protein-tyrosine phosphatase	0.0318	0.0244	0.0163
Schistosoma mansoni	protein tyrosine phosphatase	0.0318	0.0244	0.0178
Onchocerca volvulus		0.0318	0.0244	0.0407
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0318	0.0244	0.0146
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0318	0.0244	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Onchocerca volvulus		0.0318	0.0244	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0318	0.0244	0.0178
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.5121	0.5986	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Brugia malayi	Protein-tyrosine phosphatase	0.0318	0.0244	0.0163
Schistosoma mansoni	pcd6 interacting protein-related	0.0318	0.0244	0.0178
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0318	0.0244	0.0178
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0318	0.0244	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0318	0.0244	0.0163
Onchocerca volvulus		0.0318	0.0244	0.0407
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0318	0.0244	0.0163
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0318	0.0244	0.0146
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0318	0.0244	0.0163
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0318	0.0244	0.0163
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0318	0.0244	0.0146
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0318	0.0244	0.0146
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Echinococcus multilocularis		0.0318	0.0244	0.0146
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0318	0.0244	0.0163
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0318	0.0244	0.0146
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0318	0.0244	0.0163
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.5121	0.5986	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0318	0.0244	0.0146

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.1623 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.6964 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	7.9433 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ]	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1498305

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1367218