TDR Targets

Basic information

Technical information

TDR Targets ID: 1367614
Name: [1-(4-fluorophenyl)sulfonylpiperidin-3-yl]-[4 -(4-methoxyphenyl)piperazin-1-yl]methanone
MW: 461.55 | Formula: C23H28FN3O4S
H donors: 0 H acceptors: 3 LogP: 2.69 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)N1CCN(CC1)C(=O)C1CCCN(C1)S(=O)(=O)c1ccc(cc1)F
InChi: 1S/C23H28FN3O4S/c1-31-21-8-6-20(7-9-21)25-13-15-26(16-14-25)23(28)18-3-2-12-27(17-18)32(29,30)22-10-4-19(24)5-11-22/h4-11,18H,2-3,12-17H2,1H3
InChiKey: WLRBGLWZFMGERU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[1-(4-fluorophenyl)sulfonyl-3-piperidyl]-[4-(4-methoxyphenyl)piperazin-1-yl]methanone
[1-(4-fluorophenyl)sulfonyl-3-piperidinyl]-[4-(4-methoxyphenyl)-1-piperazinyl]methanone

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	N-terminal motif family protein	0.0182	0.1771	0.7689
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0013	0.0021	0.4833
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0015	0.0044	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0015	0.0044	0.0085
Onchocerca volvulus		0.0015	0.0044	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0668	0.2898
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0021	0.0092
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0015	0.0044	0.0897
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.002	0.0094	0.0181
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0011	0	0.5
Onchocerca volvulus		0.0015	0.0044	0.0129
Schistosoma mansoni	pcd6 interacting protein-related	0.0015	0.0044	0.0897
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Mycobacterium leprae	Possible regulatory protein	0.0013	0.0021	1
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0013	0.0021	0.0021
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Brugia malayi	bHLH-PAS transcription factor	0.0036	0.0265	0.1149
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0015	0.0044	0.0085
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.002	0.0094	0.0094
Leishmania major	protein kinase, putative	0.0017	0.0062	0.1267
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.002	0.0094	0.0094
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0015	0.0044	0.019
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0044	0.019
Schistosoma mansoni	protein tyrosine phosphatase	0.0015	0.0044	0.0897
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0015	0.0044	0.0085
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0015	0.0044	0.0044
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Onchocerca volvulus		0.0015	0.0044	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Mycobacterium ulcerans	putative regulatory protein	0.0036	0.0265	0.543
Brugia malayi	hypothetical protein	0.0015	0.0044	0.019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Onchocerca volvulus		0.0015	0.0044	0.0129
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0015	0.0044	0.0897
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0044	0.019
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0015	0.0044	0.0897
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0015	0.0044	0.019
Onchocerca volvulus		0.0015	0.0044	0.0129
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0044	0.019
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0013	0.0021	0.4833
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0015	0.0044	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0015	0.0044	0.0085
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0044	0.019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0015	0.0044	0.0897
Onchocerca volvulus		0.008	0.0717	0.398
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.002	0.0094	0.0181
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0015	0.0044	0.0044
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0015	0.0044	0.0085
Brugia malayi	PAS domain containing protein	0.0049	0.0396	0.1721
Brugia malayi	Protein-tyrosine phosphatase	0.0015	0.0044	0.019
Onchocerca volvulus		0.0015	0.0044	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0015	0.0044	0.5
Onchocerca volvulus		0.0015	0.0044	0.0129
Loa Loa (eye worm)	cytochrome P450 family protein	0.0049	0.0398	0.1727
Onchocerca volvulus		0.0015	0.0044	0.0129
Onchocerca volvulus		0.0015	0.0044	0.0129
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0058	0.0487	1
Onchocerca volvulus		0.0015	0.0044	0.0129
Loa Loa (eye worm)	hypothetical protein	0.009	0.0822	0.3569
Onchocerca volvulus		0.0015	0.0044	0.0129
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0152	0.1458	0.6333
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0044	0.019
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0044	0.019
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0044	0.019
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0015	0.0044	0.0085
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0015	0.0044	0.019
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0015	0.0044	0.0085
Onchocerca volvulus		0.0015	0.0044	0.0129
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0044	0.019
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0015	0.0044	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0015	0.0044	0.0085
Giardia lamblia	Protein tyrosine phosphatase	0.0015	0.0044	0.5
Trichomonas vaginalis	pten, drome, putative	0.0015	0.0044	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0015	0.0044	0.0044
Echinococcus multilocularis		0.0015	0.0044	0.0044
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0015	0.0044	0.019
Onchocerca volvulus		0.0015	0.0044	0.0129
Brugia malayi	hypoxia-induced factor 1	0.0152	0.1458	0.6333
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0015	0.0044	0.0085
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0015	0.0044	0.0085
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.002	0.0094	0.0181
Onchocerca volvulus		0.0015	0.0044	0.0129
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0015	0.0044	0.0044
Brugia malayi	hypothetical protein	0.0015	0.0044	0.019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0054	0.0447	0.1941
Brugia malayi	hypothetical protein	0.0015	0.0044	0.019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.002	0.0094	0.0094
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0015	0.0044	1
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0013	0.0021	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Onchocerca volvulus		0.0015	0.0044	0.0129
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0044	0.019
Brugia malayi	Protein-tyrosine phosphatase	0.0095	0.0872	0.3785
Onchocerca volvulus		0.0015	0.0044	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Onchocerca volvulus		0.0015	0.0044	0.0129
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.002	0.0094	0.1922
Brugia malayi	hypothetical protein	0.0015	0.0044	0.019
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0058	0.0487	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0013	0.0021	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.002	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0015	0.0044	0.0085
Onchocerca volvulus	4.1 G protein, putative homolog	0.0015	0.0044	0.0129
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0015	0.0044	0.0085
Leishmania major	protein kinase, putative	0.0013	0.0021	0.0433
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0013	0.0021	0.4833
Onchocerca volvulus		0.0015	0.0044	0.0129
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Leishmania major	tyrosine specific protein phosphatase, putative	0.0015	0.0044	0.0897
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0058	0.0487	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0044	0.019
Brugia malayi	hypothetical protein	0.0015	0.0044	0.019
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.002	0.0094	0.1922
Schistosoma mansoni	aryl hydrocarbon receptor	0.0049	0.0396	0.8135
Loa Loa (eye worm)	hypothetical protein	0.0165	0.159	0.6905
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0015	0.0044	0.0085
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0015	0.0044	0.0897
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0668	0.2898
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0015	0.0044	0.0897
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0234	0.2303	1
Echinococcus multilocularis	transfer RNA-Lys	0.0036	0.0265	0.0265
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.002	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Onchocerca volvulus		0.0015	0.0044	0.0129
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Brugia malayi	Cytochrome P450 family protein	0.0049	0.0398	0.1727
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0015	0.0044	0.0044
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.002	0.0094	0.1922
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0044	0.019
Onchocerca volvulus		0.0036	0.0265	0.1392
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0058	0.0487	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0506	0.5113	0.9903
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0015	0.0044	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Brugia malayi	follicle stimulating hormone receptor	0.0234	0.2303	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0506	0.5113	0.5113
Loa Loa (eye worm)	hypothetical protein	0.0182	0.1771	0.7689
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0015	0.0044	0.0044
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0015	0.0044	0.0897
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0015	0.0044	0.5
Onchocerca volvulus		0.0015	0.0044	0.0129
Brugia malayi	hypothetical protein	0.0165	0.159	0.6905
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0015	0.0044	0.0044
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0015	0.0044	0.0897
Loa Loa (eye worm)	hypothetical protein	0.0075	0.0668	0.2898
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0015	0.0044	0.019
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0013	0.0021	0.4833
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0015	0.0044	0.0897
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0013	0.0021	0.0092
Onchocerca volvulus		0.0015	0.0044	0.0129
Brugia malayi	Protein-tyrosine phosphatase 1	0.0015	0.0044	0.019
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0015	0.0044	0.0044
Onchocerca volvulus		0.0015	0.0044	0.0129
Echinococcus granulosus	single minded 2	0.0036	0.0265	0.0512
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0015	0.0044	0.0044
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0013	0.0021	0.0021
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0044	0.019
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0015	0.0044	0.0044
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Schistosoma mansoni	single-minded	0.0049	0.0396	0.8135
Schistosoma mansoni	protein tyrosine phosphatase	0.002	0.0094	0.1922
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0015	0.0044	0.019
Onchocerca volvulus		0.0015	0.0044	0.0129
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0015	0.0044	1
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0013	0.0021	0.4833
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0015	0.0044	0.0897
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0058	0.0487	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.002	0.0094	0.1922
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0044	0.019
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0058	0.0487	0.0487
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.002	0.0094	0.1922
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0511	0.5163	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0015	0.0044	0.0044
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0058	0.0487	0.0944
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0058	0.0487	0.2115
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.002	0.0094	0.0094
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0015	0.0044	0.0897
Echinococcus granulosus	aryl hydrocarbon receptor	0.0013	0.0021	0.0041
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0015	0.0044	0.0044
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0013	0.0021	0.4833
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.002	0.0094	0.0407
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0182	0.1771	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0015	0.0044	0.0044
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Schistosoma mansoni	protein tyrosine phosphatase	0.0015	0.0044	0.0897
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0044	0.019
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0015	0.0044	0.019
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0015	0.0044	0.0044
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0044	0.019
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0015	0.0044	0.0044
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0013	0.0021	0.0433
Echinococcus multilocularis	hypothetical protein	0.0015	0.0044	0.0044
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0015	0.0044	0.019

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	18.3489 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1495655

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1367614