Detailed information for compound 1369632

Basic information

Technical information
  • TDR Targets ID: 1369632
  • Name: (E)-2-cyano-3-(3-hydroxyphenyl)prop-2-enoic a cid
  • MW: 189.167 | Formula: C10H7NO3
  • H donors: 2 H acceptors: 4 LogP: 1.45 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#C/C(=C\c1cccc(c1)O)/C(=O)O
  • InChi: 1S/C10H7NO3/c11-6-8(10(13)14)4-7-2-1-3-9(12)5-7/h1-5,12H,(H,13,14)/b8-4+
  • InChiKey: HPLNTJVXWMJLNJ-XBXARRHUSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-cyano-3-(3-hydroxyphenyl)prop-2-enoic acid
  • 2-cyano-3-(3-hydroxyphenyl)acrylic acid
  • (E)-2-cyano-3-(3-hydroxyphenyl)acrylic acid
  • SPBio_001421
  • Spectrum3_001505
  • DivK1c_000765
  • Spectrum2_001471
  • Spectrum5_001637
  • BBV-022379
  • KBioSS_001977
  • Spectrum_001497
  • KBioGR_000705
  • KBio2_001977
  • SPECTRUM1502095
  • KBio1_000765
  • BSPBio_003149
  • .alpha.-Cyano-3-hydroxycinnamic acid
  • 2-Propenoic acid, 2-cyano-3-(3-hydroxyphenyl)-
  • NCGC00095882-01
  • KBio2_004545
  • KBio2_007113
  • Spectrum4_000333
  • 144630_ALDRICH
  • alpha-CYANO-3-HYDROXYCINNAMIC ACID
  • KBio3_002649
  • IDI1_000765
  • NINDS_000765

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0527 0.1178
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0208 0.0416
Schistosoma mansoni tyrosine kinase 0.006 0.1888 0.4221
Schistosoma mansoni nuclear hormone receptor 0.001 0.0208 0.0465
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0208 0.0416
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0208 0.0416
Brugia malayi nuclear receptor NHR-88 0.001 0.0208 0.0416
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0165 0.0321
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0527 0.3512
Schistosoma mansoni nuclear receptor 0.0005 0.0023 0.005
Brugia malayi cathepsin B-like cysteine proteinase 0.0137 0.4473 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0208 0.0416
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.4812 1
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0527 0.1133
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0208 0.0416
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0208 0.0416
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0527 0.3512
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0208 0.0416
Brugia malayi hypothetical protein 0.0005 0.0042 0.0045
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0045 0.138 0.1308
Schistosoma mansoni zinc finger protein 0.0005 0.0023 0.005
Onchocerca volvulus 0.0029 0.0854 1
Brugia malayi hypothetical protein 0.0005 0.0042 0.0045
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0208 0.0416
Echinococcus granulosus dna polymerase kappa 0.002 0.0527 0.1133
Echinococcus multilocularis dna polymerase kappa 0.002 0.0527 0.1133
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.4812 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0208 0.2229
Loa Loa (eye worm) hypothetical protein 0.001 0.0208 0.0416
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.3512
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0208 0.0465
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0527 0.0448
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.1444 0.3195
Loa Loa (eye worm) TK/EGFR protein kinase 0.0061 0.1924 0.4274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0208 0.0416
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0527 0.1178
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0137 0.4473 1
Giardia lamblia Fructose-bisphosphate aldolase 0.03 1 1
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0527 0.0973
Schistosoma mansoni nuclear receptor 0.0005 0.0023 0.005
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0042 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0208 0.0416
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.138 0.3086
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0208 0.0416
Loa Loa (eye worm) hypothetical protein 0.001 0.0208 0.0416
Echinococcus granulosus cathepsin b 0.0137 0.4473 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0137 0.4473 1
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0208 0.0416
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0208 0.0416
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.1971 0.4407
Loa Loa (eye worm) hypothetical protein 0.0073 0.2334 0.5195
Loa Loa (eye worm) hypothetical protein 0.0006 0.0065 0.0095
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0045 0.138 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.3512
Plasmodium falciparum DNA repair protein REV1, putative 0.0006 0.0065 0.5
Schistosoma mansoni tyrosine kinase 0.006 0.1888 0.4221
Giardia lamblia Cathepsin B precursor 0.0045 0.138 0.1324
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0208 0.0465
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.3512
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.3512
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.3512
Echinococcus granulosus cathepsin b 0.0137 0.4473 1
Brugia malayi Protein kinase domain containing protein 0.0074 0.2371 0.5278
Trypanosoma brucei cysteine peptidase C (CPC) 0.0045 0.138 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0208 0.0416
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0527 0.3512
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0023 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 1 1
Schistosoma mansoni thyroid hormone receptor 0.001 0.0208 0.0465
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0023 0.005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0208 0.0416
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0208 0.0416
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1444 0.323
Brugia malayi steroid hormone receptor 0.001 0.0208 0.0416
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0527 0.1048
Loa Loa (eye worm) hypothetical protein 0.001 0.0208 0.0416
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 1 1
Brugia malayi nuclear hormone receptor 0.001 0.0208 0.0416
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0208 0.0465
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0527 0.1048
Loa Loa (eye worm) hypothetical protein 0.0005 0.0042 0.0045
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0208 0.0416
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1444 0.3195
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0208 0.0465
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0061 0.1924 0.4274
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0208 0.0416
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0208 0.0416
Loa Loa (eye worm) hypothetical protein 0.0005 0.0042 0.0045
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0065 0.5
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0137 0.4473 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0527 0.3512
Loa Loa (eye worm) cathepsin B 0.0045 0.138 0.3051
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0165 0.0321
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0208 0.0416
Schistosoma mansoni DNA polymerase eta 0.002 0.0527 0.1178
Schistosoma mansoni cpg binding protein 0.0031 0.0911 0.2036
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1745 1
Echinococcus granulosus FTZ F1 alpha 0.001 0.0208 0.0416
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0165 0.0321
Echinococcus granulosus cpg binding protein 0.0031 0.0911 0.1996
Schistosoma mansoni tyrosine kinase 0.006 0.1888 0.4221
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0527 0.1133
Trypanosoma brucei unspecified product 0.002 0.0527 0.3512
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0023 0.005
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0208 0.0416
Echinococcus multilocularis insulin receptor 0.0134 0.4402 0.9841
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0208 0.0416
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.3512
Brugia malayi CXXC zinc finger family protein 0.0029 0.0854 0.1868
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0105 0.0234
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.1444 0.3195
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0045 0.138 0.2984
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0319 0.1931
Echinococcus granulosus insulin receptor 0.0134 0.4402 0.9841
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0105 0.0185
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0134 0.4402 0.9841
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0208 0.0416
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0005 0.0042 0.0045
Trypanosoma brucei unspecified product 0.0014 0.0319 0.1931
Trypanosoma brucei unspecified product 0.0014 0.0319 0.1931
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0042 0.0045
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0527 0.1048
Loa Loa (eye worm) TK/INSR protein kinase 0.0134 0.4402 0.9841
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0527 0.1133
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0527 0.1048
Schistosoma mansoni tyrosine kinase 0.0061 0.1924 0.4303
Echinococcus multilocularis cpg binding protein 0.0031 0.0911 0.1996
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0527 0.1133
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0208 0.0416
Onchocerca volvulus 0.001 0.0208 0.2229
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0854 0.1868
Echinococcus granulosus dna polymerase eta 0.002 0.0527 0.1133
Giardia lamblia Cathepsin B precursor 0.0045 0.138 0.1324
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0105 0.0185
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0065 0.0145
Leishmania major DNA polymerase eta, putative 0.002 0.0527 0.3512
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0105 0.0185
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1444 0.323
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0208 0.0416
Echinococcus granulosus epidermal growth factor receptor 0.0061 0.1924 0.4274
Brugia malayi Furin-like cysteine rich region family protein 0.0061 0.1924 0.4274
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1444 0.3195
Echinococcus multilocularis cathepsin b 0.0137 0.4473 1
Brugia malayi ecdysteroid receptor 0.001 0.0208 0.0416
Echinococcus multilocularis 0.0018 0.0451 0.0962
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0005 0.0042 0.0045
Loa Loa (eye worm) hypothetical protein 0.0005 0.0042 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0208 0.0416
Schistosoma mansoni coup transcription factor 0.001 0.0208 0.0465
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0208 0.0465
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0208 0.0416
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0527 0.1048
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0208 0.0465
Schistosoma mansoni cpg binding protein 0.0031 0.0911 0.2036
Schistosoma mansoni tyrosine kinase 0.0134 0.4402 0.9842
Giardia lamblia Cathepsin B precursor 0.0045 0.138 0.1324
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.3512
Brugia malayi Protein kinase domain containing protein 0.0134 0.4402 0.9841
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0527 0.1133
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.4812 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.1444 0.3195
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0208 0.2229
Loa Loa (eye worm) hypothetical protein 0.001 0.0208 0.0416
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0208 0.0416
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0042 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.1444 0.323
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.3512
Echinococcus granulosus epidermal growth factor receptor 0.0061 0.1924 0.4274
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0042 0.0045
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0208 0.0465
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0161 0.0312
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0208 0.0416
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0042 0.0095
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0208 0.0465
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0319 0.1931
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0137 0.4473 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 1 1
Brugia malayi polk-prov protein 0.0006 0.0065 0.0095
Echinococcus multilocularis cathepsin b 0.0137 0.4473 1
Schistosoma mansoni cpg binding protein 0.0029 0.0854 0.1909
Loa Loa (eye worm) hypothetical protein 0.001 0.0208 0.0416
Treponema pallidum fructose-bisphosphate aldolase 0.03 1 0.5
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0208 0.0416
Loa Loa (eye worm) hypothetical protein 0.002 0.0527 0.1133
Brugia malayi nuclear receptor RXR 0.0005 0.0042 0.0045
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0023 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0208 0.0416
Loa Loa (eye worm) hypothetical protein 0.001 0.0208 0.0416
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 1 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0208 0.0416
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0208 0.0416
Loa Loa (eye worm) hypothetical protein 0.0137 0.4473 1
Giardia lamblia DINP protein human, muc B family 0.002 0.0527 0.0465
Echinococcus multilocularis dna polymerase eta 0.002 0.0527 0.1133
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0208 0.0416
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0208 0.0416
Echinococcus multilocularis epidermal growth factor receptor 0.0061 0.1924 0.4274
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0527 0.3512
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0134 0.4402 0.9841
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0208 0.2229
Schistosoma mansoni tyrosine kinase 0.0061 0.1924 0.4303
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0208 0.0416
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0208 0.0416
Toxoplasma gondii cathepsin B 0.0045 0.138 0.7827
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0208 0.0416
Echinococcus multilocularis epidermal growth factor receptor 0.0061 0.1924 0.4274
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0527 0.0448
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0137 0.4473 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0319 0.1931
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0208 0.0416
Loa Loa (eye worm) hypothetical protein 0.001 0.0208 0.0416
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0527 0.0973
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0208 0.0416
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0208 0.0416
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0023 0.005
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.3512
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.1444 0.3195
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0527 0.3512
Leishmania major DNA polymerase kappa, putative 0.002 0.0527 0.3512
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0208 0.0416
Schistosoma mansoni tyrosine kinase 0.0061 0.1924 0.4303
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0105 0.0185
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0208 0.0465
Schistosoma mansoni thyroid hormone receptor 0.001 0.0208 0.0465
Schistosoma mansoni tyrosine kinase 0.0134 0.4402 0.9842

Activities

Activity type Activity value Assay description Source Reference
Inhibition (ADMET) = 89.68761407 % Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Inhibition (ADMET) = 102.6094551 % Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM ChEMBL. 23571415
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.