Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | troponin I type 3 (cardiac) | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | thyrotropin-releasing hormone receptor | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | troponin C type 1 (slow) | Starlite/ChEMBL | No references |
Homo sapiens | troponin T type 2 (cardiac) | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | larval opioid receptor | thyrotropin-releasing hormone receptor | 398 aa | 324 aa | 23.5 % |
Plasmodium falciparum | centrin-3 | troponin C type 1 (slow) | 161 aa | 148 aa | 33.1 % |
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA binding protein | 0.0062 | 0.1626 | 0.3985 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.1626 | 0.3985 |
Loa Loa (eye worm) | troponin | 0.0076 | 0.216 | 0.5295 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0059 | 0.0144 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0553 | 0.0497 |
Echinococcus granulosus | geminin | 0.0166 | 0.5417 | 0.539 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.1626 | 0.1576 |
Schistosoma mansoni | troponin I | 0.0129 | 0.4079 | 0.4044 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0553 | 0.0497 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1564 | 0.3834 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.2044 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0867 | 0.0813 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.1626 | 0.3985 |
Loa Loa (eye worm) | troponin I | 0.0129 | 0.4079 | 1 |
Echinococcus multilocularis | thyrotropin releasing hormone receptor | 0.0291 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0059 | 0.0144 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.1626 | 0.1576 |
Schistosoma mansoni | thyrotropin-releasing hormone receptor | 0.0291 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0033 | 0.0553 | 0.0497 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0553 | 0.0497 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0553 | 0.1356 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.1626 | 0.3985 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.2044 | 0.5 |
Echinococcus multilocularis | oncosphere protein tso22e oncosphere protein tso22d oncosphere protein tso22c oncosphere protein tso22b oncosphere protein tso22 | 0.016 | 0.5214 | 0.5185 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.1626 | 0.3985 |
Brugia malayi | Troponin family protein | 0.0129 | 0.4079 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.216 | 0.5295 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.2044 | 0.1997 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0553 | 0.1356 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1564 | 0.3834 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.1626 | 0.1576 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0059 | 0.0144 |
Brugia malayi | Troponin T | 0.0076 | 0.216 | 0.5295 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.1626 | 0.1576 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.4079 | 1 |
Brugia malayi | Troponin T | 0.0076 | 0.216 | 0.5295 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0059 | 0.0144 |
Echinococcus multilocularis | troponin i | 0.0129 | 0.4079 | 0.4044 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.4079 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0867 | 0.2126 |
Brugia malayi | Troponin I | 0.0129 | 0.4079 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.1626 | 0.1576 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.2044 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.2044 | 0.1997 |
Brugia malayi | Troponin T | 0.0076 | 0.216 | 0.5295 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0531 | 0.1303 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0553 | 0.1356 |
Echinococcus multilocularis | geminin | 0.0166 | 0.5417 | 0.539 |
Onchocerca volvulus | Troponin T, skeletal muscle homolog | 0.0076 | 0.216 | 0.3448 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.2044 | 0.1997 |
Schistosoma mansoni | hypothetical protein | 0.0129 | 0.4079 | 0.4044 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.1626 | 0.1576 |
Schistosoma mansoni | troponin I | 0.0129 | 0.4079 | 0.4044 |
Schistosoma mansoni | troponin t invertebrate | 0.016 | 0.5214 | 0.5185 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1564 | 0.3834 |
Onchocerca volvulus | Troponin T, skeletal muscle homolog | 0.016 | 0.5214 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.5417 | 0.539 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0553 | 0.0497 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0553 | 0.0497 |
Onchocerca volvulus | Troponin I homolog | 0.0129 | 0.4079 | 0.7566 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.5417 | 0.539 |
Schistosoma mansoni | lamin | 0.0033 | 0.0553 | 0.0497 |
Schistosoma mansoni | troponin I | 0.0129 | 0.4079 | 0.4044 |
Echinococcus granulosus | troponin i | 0.0129 | 0.4079 | 0.4044 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0553 | 0.0497 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1564 | 0.3834 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0553 | 0.1356 |
Echinococcus granulosus | oncosphere protein Tso22e | 0.016 | 0.5214 | 0.5185 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.2044 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0553 | 0.1356 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.1626 | 0.1576 |
Loa Loa (eye worm) | troponin T | 0.0076 | 0.216 | 0.5295 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0867 | 0.2126 |
Schistosoma mansoni | troponin I | 0.0129 | 0.4079 | 0.4044 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.2044 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.1626 | 0.3985 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.2044 | 0.1997 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.2044 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.0553 | 0.0497 |
Brugia malayi | hypothetical protein | 0.0076 | 0.216 | 0.5295 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 17.936 uM | PUBCHEM_BIOASSAY: Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493008, AID493018, AID504382, AID504383] | ChEMBL. | No reference |
Potency (functional) | 8.2753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 13.1154 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: qHTS for Small Molecule Agonists and Allosteric Enhancers of Human TRH Receptor: Confirmation Screen for Agonists. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485365, AID493056] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] | ChEMBL. | No reference |
Potency (binding) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 75.6863 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.