Detailed information for compound 1375482

Basic information

Technical information
  • TDR Targets ID: 1375482
  • Name: (4E)-4-(ethoxymethylidene)-2-(4-methoxyphenyl )isoquinoline-1,3-dione
  • MW: 323.343 | Formula: C19H17NO4
  • H donors: 0 H acceptors: 2 LogP: 2.98 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCO/C=C\1/C(=O)N(c2ccc(cc2)OC)C(=O)c2c1cccc2
  • InChi: 1S/C19H17NO4/c1-3-24-12-17-15-6-4-5-7-16(15)18(21)20(19(17)22)13-8-10-14(23-2)11-9-13/h4-12H,3H2,1-2H3/b17-12+
  • InChiKey: YXSGCTHHAXSUFW-SFQUDFHCSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(ethoxymethylidene)-2-(4-methoxyphenyl)isoquinoline-1,3-dione
  • (4E)-4-(ethoxymethylene)-2-(4-methoxyphenyl)isoquinoline-1,3-dione
  • 4-(ethoxymethylene)-2-(4-methoxyphenyl)isoquinoline-1,3-dione
  • 4-(ethoxymethylene)-2-(4-methoxyphenyl)isoquinoline-1,3-quinone
  • (4E)-4-(ethoxymethylene)-2-(4-methoxyphenyl)isoquinoline-1,3-quinone
  • SMR000048645
  • STOCK5S-57841
  • ZINC02358065
  • MLS001007186

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SUMO1/sentrin specific peptidase 6 Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4E Starlite/ChEMBL No references
Homo sapiens SUMO/sentrin specific peptidase family member 8 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens sphingomyelin phosphodiesterase 1, acid lysosomal Starlite/ChEMBL No references
Homo sapiens caspase 3, apoptosis-related cysteine peptidase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum hypothetical protein Get druggable targets OG5_129942 All targets in OG5_129942
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of three potential ubiquitin-like protein-specific protease genes Get druggable targets OG5_129942 All targets in OG5_129942
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni family C48 unassigned peptidase (C48 family) Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus multilocularis caspase Get druggable targets OG5_130238 All targets in OG5_130238
Loa Loa (eye worm) Ulp1 protease Get druggable targets OG5_129942 All targets in OG5_129942
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_129942 All targets in OG5_129942
Trichomonas vaginalis Sentrin-specific protease, putative Get druggable targets OG5_129942 All targets in OG5_129942
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein Get druggable targets OG5_129942 All targets in OG5_129942
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus granulosus sentrin specific protease 8 Get druggable targets OG5_129942 All targets in OG5_129942
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_129942 All targets in OG5_129942
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K08597 sentrin-specific protease 8, putative Get druggable targets OG5_129942 All targets in OG5_129942
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase Get druggable targets OG5_130238 All targets in OG5_130238
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Echinococcus granulosus caspase Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni caspase-7 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Schistosoma mansoni caspase-3 (C14 family) Get druggable targets OG5_130238 All targets in OG5_130238
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Echinococcus multilocularis caspase 3 Get druggable targets OG5_130238 All targets in OG5_130238
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis sentrin specific protease 8 Get druggable targets OG5_129942 All targets in OG5_129942
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative Get druggable targets OG5_128629 All targets in OG5_128629
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K04397 caspase 7, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase Get druggable targets OG5_129942 All targets in OG5_129942
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_129942 All targets in OG5_129942
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of three potential ubiquitin-like protein-specific protease genes Get druggable targets OG5_129942 All targets in OG5_129942
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128629 All targets in OG5_128629
Candida albicans one of four genes similar to C. elegans asm2 lysosomal acid sphingomyelin phosphodiesterase (XL940) Get druggable targets OG5_128629 All targets in OG5_128629
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K02187 caspase 3, apoptosis-related cysteine protease, putative Get druggable targets OG5_130238 All targets in OG5_130238
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cell death protein 3 precursor caspase 3, apoptosis-related cysteine peptidase 277 aa 253 aa 38.7 %
Plasmodium falciparum sentrin-specific protease 1 SUMO/sentrin specific peptidase family member 8 212 aa 197 aa 23.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.018 0.0108
Loa Loa (eye worm) Ulp1 protease 0.0031 0.008 0.0086
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.9351 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0071 0.4538 0.4494
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0031 0.008 0.0086
Trypanosoma brucei polo-like protein kinase 0.0114 0.9351 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.4538 0.4494
Echinococcus multilocularis caspase 8 0.0032 0.018 0.0101
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.9351 1
Echinococcus multilocularis caspase 0.012 1 1
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0031 0.008 0.4459
Trypanosoma cruzi hypothetical protein 0.0096 0.7305 0.7812
Trypanosoma brucei metacaspase MCA2 0.0032 0.018 0.0193
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.9351 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.9351 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0071 0.4538 0.4494
Loa Loa (eye worm) hypothetical protein 0.01 0.7748 0.8286
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.018 1
Echinococcus multilocularis caspase 2 0.0032 0.018 0.0101
Echinococcus granulosus caspase 8 0.0032 0.018 0.0101
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.291 0.3053
Echinococcus multilocularis caspase 3 0.0088 0.6416 0.6387
Giardia lamblia Kinase, PLK 0.0114 0.9351 1
Schistosoma mansoni caspase-7 (C14 family) 0.0032 0.018 0.0101
Loa Loa (eye worm) hypothetical protein 0.0031 0.008 0.0086
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.9351 1
Brugia malayi Cell death protein 3 precursor 0.0032 0.018 0.0193
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.018 0.0108
Schistosoma mansoni jumonji domain containing protein 0.0071 0.4538 0.4494
Trypanosoma brucei Metacaspase-4 0.0032 0.018 0.0193
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.018 0.0108
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.018 0.0108
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.0031 0.008 0.5
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0096 0.7305 0.7793
Trypanosoma brucei metacaspase 5, putative 0.0032 0.018 0.0193
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.018 0.0193
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.018 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.7748 0.8271
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.018 0.0108
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.9351 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.9351 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.018 0.0108
Echinococcus granulosus caspase 2 0.0032 0.018 0.0101
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0032 0.018 0.0101
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0031 0.008 0.4459
Trypanosoma brucei metacaspase MCA3 0.0032 0.018 0.0193
Echinococcus multilocularis sentrin specific protease 8 0.0096 0.7305 0.7283
Loa Loa (eye worm) hypothetical protein 0.0031 0.008 0.0086
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.0031 0.008 0.5
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.018 1
Trichomonas vaginalis Sentrin-specific protease, putative 0.0096 0.7305 0.7793
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0031 0.008 0.0086
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.4538 0.4494
Loa Loa (eye worm) hypothetical protein 0.0032 0.018 0.0193
Loa Loa (eye worm) hypothetical protein 0.0032 0.018 0.0193
Trypanosoma brucei metacaspase 0.0032 0.018 0.0193
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.018 0.0108
Plasmodium vivax hypothetical protein, conserved 0.0032 0.018 1
Schistosoma mansoni caspase-3 (C14 family) 0.012 1 1
Brugia malayi jmjC domain containing protein 0.0071 0.4538 0.4853
Echinococcus granulosus sentrin specific protease 8 0.0096 0.7305 0.7283
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.018 0.0108
Leishmania major metacaspase, putative 0.0032 0.018 0.0193
Loa Loa (eye worm) Ulp1 protease 0.0096 0.7305 0.7812
Plasmodium falciparum sentrin-specific protease 1 0.0031 0.008 0.4459
Trypanosoma cruzi metacaspase, putative 0.0032 0.018 0.0193
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0096 0.7305 0.7793
Trypanosoma cruzi metacaspase, putative 0.0032 0.018 0.0193
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.018 0.0108
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0031 0.008 0.0086
Plasmodium falciparum metacaspase 1 0.0032 0.018 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.4538 0.4853
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.018 0.0108
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.9351 1
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0096 0.7305 0.7812
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.012 1 1
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0032 0.018 0.0193
Echinococcus granulosus caspase 0.012 1 1
Schistosoma mansoni caspase-7 (C14 family) 0.012 1 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.018 0.0108
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.9351 0.9346
Trypanosoma brucei SUMO1/Ulp2, putative 0.0031 0.008 0.0086
Plasmodium falciparum metacaspase-like protein 0.0032 0.018 1
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.9351 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.9351 0.9346
Loa Loa (eye worm) hypothetical protein 0.0031 0.008 0.0086
Plasmodium vivax sentrin-specific protease 1, putative 0.0031 0.008 0.4459
Brugia malayi jmjC domain containing protein 0.0071 0.4538 0.4853
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0096 0.7305 0.7793
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0031 0.008 0.4459
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.9351 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.9351 1
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0031 0.008 0.0086
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.01 0.7748 0.8271
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0031 0.008 0.0086
Schistosoma mansoni kinase 0.0058 0.3079 0.3023
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.9351 1
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.291 0.3053
Trypanosoma cruzi metacaspase, putative 0.0032 0.018 0.0193
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0031 0.008 0.0086
Plasmodium vivax metacaspase 1, putative 0.0032 0.018 1
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0096 0.7305 0.7283
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.4538 0.4494
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.018 0.0193
Onchocerca volvulus Cell death protein 3 homolog 0.0032 0.018 0.0108
Echinococcus granulosus caspase 3 0.0088 0.6416 0.6387
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.9351 1
Trypanosoma cruzi metacaspase, putative 0.0032 0.018 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.018 0.0108
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.018 0.0108
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.4538 0.4494
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0096 0.7305 0.7793
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.9351 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.018 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.018 0.0108
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.9351 0.9346
Plasmodium vivax sentrin-specific protease 2, putative 0.0031 0.008 0.4459

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 7.36 uM PUBCHEM_BIOASSAY: Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2599, AID434973, AID489001] ChEMBL. No reference
IC50 (functional) = 8.55 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2575, AID2582, AID2599] ChEMBL. No reference
IC50 (functional) = 11.6 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2575, AID2582, AID434986] ChEMBL. No reference
IC50 (functional) = 25.8 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for inhibitors of Sentrin-specific protease 7 (SENP7) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID434973, AID434986] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.8336 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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