TDR Targets

Basic information

Technical information

TDR Targets ID: 1376537
Name: 7-[[1-(4-hydroxyphenyl)tetrazol-5-yl]sulfanyl methyl]-[1,3]thiazolo[2,3-b]pyrimidin-5-one
MW: 358.398 | Formula: C14H10N6O2S2
H donors: 1 H acceptors: 5 LogP: 1.47 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(cc1)n1nnnc1SCc1cc(=O)n2c(n1)scc2
InChi: 1S/C14H10N6O2S2/c21-11-3-1-10(2-4-11)20-14(16-17-18-20)24-8-9-7-12(22)19-5-6-23-13(19)15-9/h1-7,21H,8H2
InChiKey: JLGWAIBJIFJPRK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

7-[[1-(4-hydroxyphenyl)tetrazol-5-yl]sulfanylmethyl]thiazolo[2,3-b]pyrimidin-5-one
7-[[[1-(4-hydroxyphenyl)-5-tetrazolyl]thio]methyl]-5-thiazolo[2,3-b]pyrimidinone
7-[[[1-(4-hydroxyphenyl)tetrazol-5-yl]thio]methyl]thiazolo[2,3-b]pyrimidin-5-one
7-[[1-(4-hydroxyphenyl)-1,2,3,4-tetrazol-5-yl]sulfanylmethyl]-[1,3]thiazolo[2,3-b]pyrimidin-5-one
T5335444
MLS000775496
ZINC03410973
SMR000370375

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	lysine (K)-specific methyltransferase 2A	Starlite/ChEMBL	No references
Homo sapiens	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D	Starlite/ChEMBL	No references
Homo sapiens	multiple endocrine neoplasia I		No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	huntingtin	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_133913	All targets in OG5_133913
Onchocerca volvulus	Huntingtin homolog	Get druggable targets OG5_132837	All targets in OG5_132837
Echinococcus multilocularis	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913
Schistosoma japonicum	Menin, putative	Get druggable targets OG5_133913	All targets in OG5_133913
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Brugia malayi	hypothetical protein	Get druggable targets OG5_132837	All targets in OG5_132837
Toxoplasma gondii	histone lysine methyltransferase SET1	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma mansoni	mixed-lineage leukemia protein mll	Get druggable targets OG5_130642	All targets in OG5_130642
Neospora caninum	Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a	Get druggable targets OG5_130642	All targets in OG5_130642
Schistosoma japonicum	ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative	Get druggable targets OG5_130642	All targets in OG5_130642
Onchocerca volvulus	Huntingtin homolog	Get druggable targets OG5_132837	All targets in OG5_132837
Echinococcus granulosus	dnaJ subfamily B	Get druggable targets OG5_133913	All targets in OG5_133913

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0494	0.396	0.3952
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0013	0.0094
Toxoplasma gondii	PAN domain-containing protein	0.0332	0.2637	0.3709
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.0013	0.0094
Brugia malayi	PAN domain containing protein	0.0036	0.0206	0.1462
Schistosoma mansoni	cercarial elastase (S01 family)	0.0052	0.0335	0.0323
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.0013	0.0086
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.0013	0.0031
Onchocerca volvulus		0.0052	0.0335	0.231
Brugia malayi	PAN domain containing protein	0.0036	0.0206	0.1462
Trypanosoma cruzi	hypothetical protein, conserved	0.0062	0.0418	0.5
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.0013	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0206	0.1455
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0418	0.296
Onchocerca volvulus	Huntingtin homolog	0.0148	0.1125	0.7972
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.0013	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0086
Onchocerca volvulus		0.0036	0.0206	0.1381
Brugia malayi	ecdysteroid receptor	0.0012	0.0013	0.0094
Toxoplasma gondii	1,3-beta-glucan synthase component protein	0.0836	0.6761	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0052	0.0335	0.0323
Schistosoma mansoni	cercarial elastase (S01 family)	0.0052	0.0335	0.0323
Echinococcus multilocularis	dnaJ subfamily B	0.0494	0.396	1
Echinococcus granulosus	tissue type plasminogen activator	0.0062	0.0418	0.1052
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0335	0.2376
Brugia malayi	PAN domain containing protein	0.0036	0.0206	0.1462
Schistosoma mansoni	cercarial elastase (S01 family)	0.0052	0.0335	0.0323
Echinococcus granulosus	cpg binding protein	0.0037	0.0214	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0086
Leishmania major	hypothetical protein, conserved	0.0062	0.0418	0.5
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0086
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.0013	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0335	0.2376
Onchocerca volvulus		0.0052	0.0335	0.231
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0206	0.1455
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.0013	0.0031
Echinococcus granulosus	enteropeptidase	0.0052	0.0335	0.0844
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.0013	0.0094
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0013	0.0094
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0013	0.0031
Schistosoma mansoni	cpg binding protein	0.0037	0.0214	0.0201
Schistosoma mansoni	hypothetical protein	0.0062	0.0418	0.0405
Onchocerca volvulus		0.0036	0.0206	0.1381
Loa Loa (eye worm)	PAN domain-containing protein	0.0036	0.0206	0.1455
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0052	0.0335	0.0323
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.0013	0.0031
Onchocerca volvulus		0.0052	0.0335	0.231
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0206	0.1455
Schistosoma mansoni	cercarial elastase (S01 family)	0.0052	0.0335	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0206	0.1455
Schistosoma mansoni	cercarial elastase (S01 family)	0.0052	0.0335	0.0323
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.0013	0.0094
Schistosoma mansoni	hypothetical protein	0.0052	0.0335	0.0323
Echinococcus multilocularis	Mastin	0.0052	0.0335	0.0844
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0052	0.0335	0.0323
Brugia malayi	PAN domain containing protein	0.0036	0.0206	0.1462
Brugia malayi	Protein kinase domain containing protein	0.0062	0.0418	0.2965
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0013	0.0094
Onchocerca volvulus		0.0062	0.0418	0.2899
Schistosoma mansoni	cercarial elastase (S01 family)	0.0052	0.0335	0.0323
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0197	0.1401
Brugia malayi	hypothetical protein	0.0052	0.0335	0.2382
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0206	0.1455
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0052	0.0335	0.0844
Onchocerca volvulus		0.0036	0.0206	0.1381
Onchocerca volvulus		0.0035	0.0197	0.132
Schistosoma mansoni	cpg binding protein	0.0037	0.0214	0.0201
Onchocerca volvulus	Huntingtin homolog	0.0148	0.1125	0.7972
Echinococcus granulosus	transmembrane protease serine 3	0.0052	0.0335	0.0844
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0335	0.2376
Brugia malayi	Trypsin family protein	0.0052	0.0335	0.2382
Brugia malayi	PAN domain containing protein	0.0036	0.0206	0.1462
Echinococcus granulosus	Mastin	0.0052	0.0335	0.0844
Schistosoma mansoni	cercarial elastase (S01 family)	0.0052	0.0335	0.0323
Schistosoma mansoni	cercarial elastase (S01 family)	0.0052	0.0335	0.0323
Brugia malayi	PAN domain containing protein	0.0036	0.0206	0.1462
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0335	0.2376
Brugia malayi	nuclear hormone receptor	0.0012	0.0013	0.0094
Schistosoma mansoni	cpg binding protein	0.0035	0.0197	0.0184
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.0013	0.0086
Loa Loa (eye worm)	TK/ROR protein kinase	0.0062	0.0418	0.296
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0052	0.0335	0.0844
Onchocerca volvulus		0.0036	0.0206	0.1381
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.0013	0.0086
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.0013	0.0094
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.0013	0.0094
Brugia malayi	PAN domain containing protein	0.0036	0.0206	0.1462
Loa Loa (eye worm)	hypothetical protein	0.0182	0.1408	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.0013	0.0094
Brugia malayi	PAN domain containing protein	0.0036	0.0206	0.1462
Echinococcus granulosus	dnaJ subfamily B	0.0494	0.396	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.0013	0.0086
Onchocerca volvulus		0.0052	0.0335	0.231
Brugia malayi	steroid hormone receptor	0.0012	0.0013	0.0094
Loa Loa (eye worm)	PAN domain-containing protein	0.0036	0.0206	0.1455
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.0013	0.0031
Onchocerca volvulus		0.0182	0.1408	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.0013	0.0094
Loa Loa (eye worm)	PAN domain-containing protein	0.0036	0.0206	0.1455
Onchocerca volvulus		0.0052	0.0335	0.231
Plasmodium falciparum	cysteine repeat modular protein 1	0.0062	0.0418	0.5
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.0013	0.0031
Echinococcus granulosus	glycoprotein Antigen 5	0.0052	0.0335	0.0844
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.0013	0.0094
Echinococcus multilocularis	enteropeptidase	0.0052	0.0335	0.0844
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0086
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0224	0.1747	0.1736
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.0013	0.0031
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.0013	0.0031
Echinococcus multilocularis	tissue type plasminogen activator	0.0062	0.0418	0.1052
Brugia malayi	PAN domain containing protein	0.0036	0.0206	0.1462
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0335	0.2376
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0206	0.1455
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0052	0.0335	0.0323
Toxoplasma gondii	PAN domain-containing protein	0.0332	0.2637	0.3709
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0335	0.2376
Onchocerca volvulus		0.0036	0.0206	0.1381
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.0013	0.0031
Onchocerca volvulus		0.0036	0.0206	0.1381
Schistosoma mansoni	hypothetical protein	0.0052	0.0335	0.0323
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0052	0.0335	0.0323
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.0013	0.0031
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.0452	0.0375
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0052	0.0335	0.0844
Brugia malayi	Trypsin-like protease protein 5	0.0052	0.0335	0.2382
Brugia malayi	Trypsin family protein	0.0052	0.0335	0.2382
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0086
Echinococcus multilocularis	transmembrane protease serine 3	0.0052	0.0335	0.0844
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0013	0.0031
Onchocerca volvulus		0.0036	0.0206	0.1381
Brugia malayi	Trypsin family protein	0.0052	0.0335	0.2382
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.0013	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1125	0.7989
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0086
Onchocerca volvulus		0.0036	0.0206	0.1381
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.0013	0.0031
Brugia malayi	Trypsin family protein	0.0052	0.0335	0.2382
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0013	0.0086
Onchocerca volvulus		0.0036	0.0206	0.1381
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0052	0.0335	0.0323
Mycobacterium ulcerans	hypothetical protein	0.0052	0.0335	0.5
Brugia malayi	nuclear receptor NHR-88	0.0012	0.0013	0.0094
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.0013	0.0031
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.0013	0.0094
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.0013	0.0086
Onchocerca volvulus		0.0036	0.0206	0.1381
Loa Loa (eye worm)	PAN domain-containing protein	0.0036	0.0206	0.1455
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1125	0.7989
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.0013	0.0086
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0062	0.0418	0.5
Schistosoma mansoni	cercarial elastase (S01 family)	0.0052	0.0335	0.0323
Onchocerca volvulus		0.0052	0.0335	0.231
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0052	0.0335	0.0323
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.0013	0.0031
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.0013	0.0094
Brugia malayi	hypothetical protein	0.0182	0.1408	1
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0052	0.0335	0.0844
Loa Loa (eye worm)	PAN domain-containing protein	0.0036	0.0206	0.1455
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.0013	0.0094
Loa Loa (eye worm)	trypsin family protein	0.0052	0.0335	0.2376
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0052	0.0335	0.0323
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0052	0.0335	0.2382
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0206	0.1455
Schistosoma mansoni	cercarial elastase (S01 family)	0.0052	0.0335	0.0323
Onchocerca volvulus		0.0036	0.0206	0.1381
Brugia malayi	Kringle domain containing protein	0.0062	0.0418	0.2965
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0197	0.1395
Echinococcus multilocularis	cpg binding protein	0.0037	0.0214	0.0537
Brugia malayi	hypothetical protein	0.0148	0.1125	0.7991
Brugia malayi	PAN domain containing protein	0.0036	0.0206	0.1462
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0335	0.2376
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.0013	0.0086
Schistosoma mansoni	cercarial elastase (S01 family)	0.0052	0.0335	0.0323
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.0013	0.0031
Echinococcus multilocularis	glycoprotein Antigen 5	0.0052	0.0335	0.0844
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.0516	0.0503
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.0013	0.0094
Toxoplasma gondii	kringle domain-containing protein	0.0062	0.0418	0.0323
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.0013	0.0094

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.5623 um	PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ]	ChEMBL.	No reference
Potency (functional)	5.6234 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 17.7828 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 19.9526 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))]	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))]	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1508684

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1376537