Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | breast cancer 1, early onset | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | Ras converting CAAX endopeptidase 1 | Starlite/ChEMBL | No references |
Sus scrofa | Trypsin | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin | 231 aa | 237 aa | 24.1 % |
Drosophila melanogaster | CG9997 gene product from transcript CG9997-RB | Trypsin | 231 aa | 194 aa | 23.2 % |
Drosophila melanogaster | CG30287 gene product from transcript CG30287-RA | Trypsin | 231 aa | 249 aa | 27.7 % |
Drosophila melanogaster | CG4914 gene product from transcript CG4914-RA | Trypsin | 231 aa | 245 aa | 38.8 % |
Drosophila melanogaster | CG30323 gene product from transcript CG30323-RB | Trypsin | 231 aa | 210 aa | 23.3 % |
Drosophila melanogaster | CG34436 gene product from transcript CG34436-RA | Trypsin | 231 aa | 214 aa | 22.0 % |
Drosophila melanogaster | CG6582 gene product from transcript CG6582-RA | Trypsin | 231 aa | 187 aa | 23.5 % |
Schistosoma japonicum | Enteropeptidase, putative | Trypsin | 231 aa | 262 aa | 25.6 % |
Echinococcus granulosus | glycoprotein Antigen 5 | Trypsin | 231 aa | 301 aa | 23.9 % |
Drosophila melanogaster | CG18180 gene product from transcript CG18180-RA | Trypsin | 231 aa | 233 aa | 27.9 % |
Drosophila melanogaster | Spatzle-Processing Enzyme | Trypsin | 231 aa | 271 aa | 29.1 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin | 231 aa | 235 aa | 25.5 % |
Drosophila melanogaster | CG11313 gene product from transcript CG11313-RC | Trypsin | 231 aa | 255 aa | 31.8 % |
Schistosoma japonicum | IPR001254,Peptidase S1 and S6, chymotrypsin/Hap;IPR009003,Peptidase, trypsin-like serine and cysteine,domain-containing | Trypsin | 231 aa | 225 aa | 23.1 % |
Drosophila melanogaster | CG3505 gene product from transcript CG3505-RA | Trypsin | 231 aa | 232 aa | 30.6 % |
Echinococcus granulosus | Mastin | Trypsin | 231 aa | 306 aa | 23.9 % |
Echinococcus granulosus | transmembrane protease serine 3 | Trypsin | 231 aa | 234 aa | 33.8 % |
Trypanosoma cruzi | hypothetical protein, conserved | Trypsin | 231 aa | 188 aa | 23.9 % |
Drosophila melanogaster | Jonah 66Ci | Trypsin | 231 aa | 234 aa | 32.9 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Drosophila melanogaster | CG33465 gene product from transcript CG33465-RC | Trypsin | 231 aa | 225 aa | 21.8 % |
Drosophila melanogaster | CG18420 gene product from transcript CG18420-RA | Trypsin | 231 aa | 239 aa | 28.4 % |
Drosophila melanogaster | CG13744 gene product from transcript CG13744-RA | Trypsin | 231 aa | 249 aa | 31.3 % |
Drosophila melanogaster | CG10405 gene product from transcript CG10405-RB | Trypsin | 231 aa | 242 aa | 31.8 % |
Drosophila melanogaster | CG4815 gene product from transcript CG4815-RA | Trypsin | 231 aa | 212 aa | 27.4 % |
Drosophila melanogaster | Jonah 65Aiii | Trypsin | 231 aa | 241 aa | 34.0 % |
Neospora caninum | ELMO/CED-12 family domain-containing protein, putative | Trypsin | 231 aa | 193 aa | 22.8 % |
Schistosoma japonicum | Cercarial protease precursor (EC 3.4.21.-) (Cercarial elastase), putative | Trypsin | 231 aa | 204 aa | 25.0 % |
Loa Loa (eye worm) | hypothetical protein | Trypsin | 231 aa | 238 aa | 21.4 % |
Brugia malayi | hypothetical protein | Ras converting CAAX endopeptidase 1 | 225 aa | 181 aa | 21.6 % |
Echinococcus multilocularis | glycoprotein Antigen 5 | Trypsin | 231 aa | 301 aa | 22.3 % |
Drosophila melanogaster | CG33458 gene product from transcript CG33458-RA | Trypsin | 231 aa | 254 aa | 28.4 % |
Echinococcus granulosus | enteropeptidase | Trypsin | 231 aa | 230 aa | 28.3 % |
Schistosoma japonicum | ko:K01346 pancreatic elastase II [EC3.4.21.71], putative | Trypsin | 231 aa | 303 aa | 24.1 % |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Trypsin | 231 aa | 302 aa | 24.8 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin | 231 aa | 235 aa | 25.5 % |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | Trypsin | 231 aa | 286 aa | 24.8 % |
Schistosoma japonicum | ko:K09637 transmembrane protease, serine 6, putative | Trypsin | 231 aa | 242 aa | 28.9 % |
Drosophila melanogaster | CG30288 gene product from transcript CG30288-RC | Trypsin | 231 aa | 245 aa | 29.0 % |
Drosophila melanogaster | CG31220 gene product from transcript CG31220-RB | Trypsin | 231 aa | 263 aa | 27.8 % |
Drosophila melanogaster | CG9733 gene product from transcript CG9733-RB | Trypsin | 231 aa | 262 aa | 31.3 % |
Onchocerca volvulus | Trypsin | 231 aa | 251 aa | 22.7 % | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Trypsin | 231 aa | 247 aa | 35.2 % |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | Trypsin | 231 aa | 300 aa | 22.3 % |
Echinococcus multilocularis | Mastin | Trypsin | 231 aa | 306 aa | 24.2 % |
Onchocerca volvulus | Trypsin | 231 aa | 212 aa | 21.2 % | |
Drosophila melanogaster | CG31267 gene product from transcript CG31267-RA | Trypsin | 231 aa | 233 aa | 32.2 % |
Drosophila melanogaster | CG30083 gene product from transcript CG30083-RB | Trypsin | 231 aa | 209 aa | 29.7 % |
Drosophila melanogaster | CG17239 gene product from transcript CG17239-RB | Trypsin | 231 aa | 227 aa | 33.5 % |
Drosophila melanogaster | CG31326 gene product from transcript CG31326-RA | Trypsin | 231 aa | 249 aa | 24.1 % |
Drosophila melanogaster | CG14990 gene product from transcript CG14990-RA | Trypsin | 231 aa | 238 aa | 29.4 % |
Echinococcus multilocularis | enteropeptidase | Trypsin | 231 aa | 230 aa | 27.8 % |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | Trypsin | 231 aa | 286 aa | 25.2 % |
Drosophila melanogaster | CG3916 gene product from transcript CG3916-RA | Trypsin | 231 aa | 245 aa | 31.4 % |
Echinococcus multilocularis | transmembrane protease serine 3 | Trypsin | 231 aa | 233 aa | 33.0 % |
Schistosoma japonicum | Transmembrane protease, serine 9, putative | Trypsin | 231 aa | 246 aa | 21.1 % |
Drosophila melanogaster | Jonah 99Ci | Trypsin | 231 aa | 235 aa | 31.9 % |
Drosophila melanogaster | CG9673 gene product from transcript CG9673-RB | Trypsin | 231 aa | 239 aa | 27.6 % |
Drosophila melanogaster | CG32277 gene product from transcript CG32277-RA | Trypsin | 231 aa | 221 aa | 33.5 % |
Drosophila melanogaster | Jonah 65Aii | Trypsin | 231 aa | 235 aa | 35.3 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin | 231 aa | 201 aa | 22.9 % |
Drosophila melanogaster | CG5909 gene product from transcript CG5909-RA | Trypsin | 231 aa | 256 aa | 28.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3562 | 0.1676 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0111 | 0.9654 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0114 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.3562 | 0.1755 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2266 | 0.2347 |
Toxoplasma gondii | hypothetical protein | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0111 | 0.9654 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.9654 | 0.9462 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0111 | 0.9654 | 0.9553 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3562 | 0.1676 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.3562 | 0.1676 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0111 | 0.9654 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.3562 | 0.1755 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.3562 | 0.1755 |
Toxoplasma gondii | CAAX amino terminal protease family protein | 0.0023 | 0 | 0.5 |
Plasmodium vivax | protease, putative | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2266 | 0.2347 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3562 | 0.1676 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0111 | 0.9654 | 0.5 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0111 | 0.9654 | 0.9553 |
Brugia malayi | CAAX amino terminal protease family protein | 0.0111 | 0.9654 | 0.9553 |
Mycobacterium tuberculosis | Probable integral membrane protein | 0.0023 | 0 | 0.5 |
Treponema pallidum | hypothetical protein | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0114 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2266 | 0.2347 |
Plasmodium falciparum | protease, putative | 0.0023 | 0 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0111 | 0.9654 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.3562 | 0.1755 |
Onchocerca volvulus | 0.0114 | 1 | 1 | |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0111 | 0.9654 | 0.5 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0111 | 0.9654 | 1 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.0023 | 0 | 0.5 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0111 | 0.9654 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
Mycobacterium ulcerans | integral membrane protein | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0 | 0.5 |
Chlamydia trachomatis | hypothetical protein | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable conserved integral membrane protein | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2266 | 0.2347 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0111 | 0.9654 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (binding) | = 4.74 uM | PUBCHEM_BIOASSAY: Human Ras-Converting Enzyme Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-04_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618] | ChEMBL. | No reference |
AC50 (binding) | = 4.748 uM | PUBCHEM_BIOASSAY: Trypsin Inhibition Assay Measured in Biochemical System Using Plate Reader - 2034-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2618] | ChEMBL. | No reference |
Potency (functional) | 4.1095 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] | ChEMBL. | No reference |
Potency (functional) | 26.8545 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.