Detailed information for compound 138652

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 542.672 | Formula: C31H38N6O3
  • H donors: 0 H acceptors: 4 LogP: 5.1 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1OCCCCn1cnc2c1cncn2)C1=NN(C2CCCCCC2)C(=O)C2C1CC=CC2
  • InChi: 1S/C31H38N6O3/c1-39-27-15-14-22(18-28(27)40-17-9-8-16-36-21-34-30-26(36)19-32-20-33-30)29-24-12-6-7-13-25(24)31(38)37(35-29)23-10-4-2-3-5-11-23/h6-7,14-15,18-21,23-25H,2-5,8-13,16-17H2,1H3
  • InChiKey: FZHQFKLHOFLUQF-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphodiesterase 3A, cGMP-inhibited Starlite/ChEMBL References
Homo sapiens phosphodiesterase 4D, cAMP-specific Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
Cryptosporidium parvum membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A Get druggable targets OG5_128242 All targets in OG5_128242
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein Get druggable targets OG5_132613 All targets in OG5_132613
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Neospora caninum cAMP-specific phosphodiesterase, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative Get druggable targets OG5_128242 All targets in OG5_128242
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative Get druggable targets OG5_128242 All targets in OG5_128242
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0345 0.1775
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0338 0.0404
Loa Loa (eye worm) hypothetical protein 0.0246 0.4329 0.4329
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0175 0.0865
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.005 0.067 0.3522
Loa Loa (eye worm) hypothetical protein 0.055 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0345 0.1775
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0114 0.1876 1
Brugia malayi Cam kinase protein 1 0.0032 0.0337 0.0323
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0345 0.1775
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0114 0.1876 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0114 0.1876 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0246 0.4329 0.8246
Schistosoma mansoni hypothetical protein 0.0017 0.0055 0.0094
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0337 0.0779
Schistosoma mansoni lamin 0.0029 0.0278 0.0612
Loa Loa (eye worm) hypothetical protein 0.0032 0.0337 0.0337
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0337 0.1734
Loa Loa (eye worm) hypothetical protein 0.0017 0.0055 0.0055
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0325 0.072
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0014 0.0014
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.005 0.067 0.1548
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.005 0.067 0.3522
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Trypanosoma brucei glucose transporter, putative 0.0032 0.0345 0.1775
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0056 0.0128
Leishmania major glucose transporter, lmgt1 0.0032 0.0345 0.1775
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0345 0.1775
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0178 0.0881
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.005 0.067 0.1253
Trichomonas vaginalis conserved hypothetical protein 0.005 0.067 0.3522
Toxoplasma gondii protein kinase, putative 0.0295 0.5247 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0338 0.0404
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0029 0.0014
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.005 0.067 0.1548
Toxoplasma gondii GAF domain-containing protein 0.0023 0.0178 0.0313
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0178 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0091 0.1438 0.7647
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.005 0.067 0.1253
Schistosoma mansoni protein kinase 0.0032 0.0337 0.0748
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0114 0.1876 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0946 0.5006
Echinococcus granulosus intermediate filament protein 0.0029 0.0278 0.0643
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0055 0.0055
Echinococcus multilocularis General substrate transporter 0.009 0.1415 0.3269
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0196 0.3399 0.7852
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0023 0.0178 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0122 0.0577
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.005 0.067 0.1253
Leishmania major protein kinase, putative 0.0032 0.0337 0.1734
Trypanosoma brucei glucose transporter, putative 0.0032 0.0345 0.1775
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0735 0.0721
Loa Loa (eye worm) hypothetical protein 0.0073 0.1108 0.1108
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0073 0.1108 0.1095
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.005 0.067 0.152
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.005 0.067 0.1253
Loa Loa (eye worm) hypothetical protein 0.0023 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0029 0.0278 0.0278
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0338 0.0404
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0422 0.2189
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0073 0.1108 0.1095
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.005 0.067 0.1253
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0946 0.5006
Entamoeba histolytica protein kinase, putative 0.0032 0.0337 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0345 0.1775
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.1876 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0268 0.0268
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.067 0.3522
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.1876 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0114 0.1876 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.1876 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.005 0.067 0.1253
Toxoplasma gondii hypothetical protein 0.0023 0.0178 0.0313
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0337 0.1734
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0175 0.0405
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0014 0.0033
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.1689 0.8998
Loa Loa (eye worm) hypothetical protein 0.0036 0.042 0.042
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.005 0.067 0.3522
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0337 0.0779
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.005 0.067 0.152
Trypanosoma brucei glucose transporter 2A 0.0032 0.0345 0.1775
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0056 0.0041
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0055 0.0127
Schistosoma mansoni hypothetical protein 0.0017 0.0055 0.0094
Echinococcus granulosus solute carrier family 22 0.0015 0.0014 0.0033
Leishmania major hypothetical protein, conserved 0.005 0.067 0.3522
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0178 0.3186
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.1108 0.5875
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.005 0.067 0.3522
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.1689 0.3902
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.005 0.067 0.082
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0338 0.0404
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.005 0.067 0.1253
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0337 0.0779
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0338 0.0404
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.005 0.067 0.3522
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0175 0.0373
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.005 0.067 0.067
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.067 0.3522
Schistosoma mansoni protein kinase 0.0032 0.0337 0.0748
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0175 0.0865
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0169 0.289 0.5495
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0345 0.1775
Echinococcus multilocularis solute carrier family 22 0.0015 0.0014 0.0033
Plasmodium falciparum cGMP-specific phosphodiesterase 0.005 0.067 0.082
Loa Loa (eye worm) sugar transporter 0.0015 0.0014 0.0014
Onchocerca volvulus 0.0029 0.0278 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0037 0.0422 0.2189
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0735 0.0735
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.1689 0.3902
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0175 0.0373
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0114 0.1876 1
Plasmodium falciparum protein kinase 7 0.0295 0.5247 0.6542
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0037 0.0422 0.0779
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0246 0.4329 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0114 0.1876 1
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0071 0.0303
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.005 0.067 0.1253
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.005 0.067 0.1548
Schistosoma mansoni hypothetical protein 0.0036 0.042 0.094
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0345 0.1775
Plasmodium falciparum phosphodiesterase delta, putative 0.005 0.067 0.082
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0114 0.1876 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0055 0.0127
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.1108 0.5875
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0055 0.0041
Plasmodium vivax CDK-related protein kinase 6, putative 0.0443 0.8012 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0056 0.0051
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0175 0.0201
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.1689 0.3902
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0056 0.0079
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.005 0.067 0.3522
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.005 0.067 0.1253
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0014 0.0033
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.1689 0.3902
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0325 0.0311
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.005 0.067 0.3522
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.1876 1
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0073 0.1108 0.2535
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0114 0.1876 0.4334
Trypanosoma brucei glucose transporter 1E 0.0032 0.0345 0.1775
Plasmodium falciparum protein kinase 6 0.0443 0.8012 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0056 0.0051
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0056 0.0221
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.005 0.067 0.1548
Echinococcus multilocularis lamin 0.0029 0.0278 0.0643
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0196 0.3399 0.3399
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0091 0.1438 0.7647
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0337 0.0323
Schistosoma mansoni lamin 0.0029 0.0278 0.0612
Echinococcus multilocularis musashi 0.0029 0.0278 0.0643
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0056 0.0128
Schistosoma mansoni hypothetical protein 0.0017 0.0055 0.0094
Loa Loa (eye worm) hypothetical protein 0.005 0.067 0.067
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.005 0.067 0.152
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0014 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.067 0.3522
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0114 0.1876 1
Toxoplasma gondii hypothetical protein 0.0023 0.0178 0.0313
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.1876 1
Schistosoma mansoni glucose transport protein 0.0104 0.1689 0.3882
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.005 0.067 0.3522
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0014 0.0033
Trypanosoma brucei glucose transporter, putative 0.0032 0.0345 0.1775
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.005 0.067 0.1253
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0114 0.1876 1
Echinococcus granulosus lamin 0.0029 0.0278 0.0643
Echinococcus granulosus calcium dependent protein kinase 0.003 0.03 0.0694
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Echinococcus multilocularis solute carrier family 22 0.0015 0.0014 0.0033
Toxoplasma gondii hypothetical protein 0.0065 0.0946 0.1781
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0337 0.0779
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.1689 0.3902
Brugia malayi Sugar transporter family protein 0.0104 0.1689 0.1677
Trichomonas vaginalis conserved hypothetical protein 0.005 0.067 0.3522
Echinococcus granulosus lamin dm0 0.0029 0.0278 0.0643
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0338 0.0404
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0114 0.1876 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.005 0.067 0.152
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.042 0.0406
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0345 0.1775
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0056 0.2508
Leishmania major glucose transporter, lmgt3 0.0032 0.0345 0.1775
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0338 0.0404
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.1876 1
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0325 0.9253
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0023 0.0178 1
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.005 0.067 0.082
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0056 0.0128
Onchocerca volvulus 0.0029 0.0278 1
Leishmania major cAMP-specific phosphodiesterase, putative 0.005 0.067 0.3522
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0175 0.5
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0325 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0114 0.1876 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0325 0.0325
Brugia malayi intermediate filament protein 0.0029 0.0278 0.0264
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.005 0.067 0.1253
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0345 0.1775
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.005 0.067 0.3522
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0175 0.0405
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0345 0.1775
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0175 0.3046
Schistosoma mansoni intermediate filament proteins 0.0029 0.0278 0.0612
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0114 0.1876 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.005 0.067 0.1253
Trypanosoma brucei glucose transporter, putative 0.0032 0.0345 0.1775
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0175 0.9816
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.005 0.067 0.3522
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0114 0.1876 0.4334
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0422 0.2189
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0114 0.1876 0.4315
Echinococcus granulosus solute carrier family 22 0.0015 0.0014 0.0033
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0114 0.1876 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.1876 1
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.067 0.3522
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.005 0.067 0.1548
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0338 0.0617
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0073 0.1108 0.256
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.005 0.067 0.1253
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0056 0.0128
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.005 0.067 0.1253
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0325 0.072
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0338 0.0404
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0014 0.0033
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0175 0.0865
Plasmodium vivax phosphodiesterase gamma, putative 0.005 0.067 0.082
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.005 0.067 0.0657
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0735 0.0721
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.005 0.067 0.152
Leishmania major hypothetical protein, conserved 0.005 0.067 0.3522
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.005 0.067 0.082
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0337 0.0748
Leishmania major glucose transporter, lmgt2 0.0032 0.0345 0.1775
Plasmodium falciparum GAF domain-related protein, putative 0.0023 0.0178 0.0205
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0175 0.0161
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.005 0.067 0.3522
Plasmodium falciparum cGMP-specific phosphodiesterase 0.005 0.067 0.082
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.005 0.067 0.3522
Echinococcus granulosus solute carrier family 22 0.0015 0.0014 0.0033
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0056 0.0128
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.03 0.0694
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.005 0.067 0.082
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0337 0.0779
Trypanosoma brucei glucose transporter, putative 0.0032 0.0345 0.1775
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.005 0.067 0.1253
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0114 0.1876 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0325 0.0325
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.011 0.5818
Echinococcus multilocularis GPCR, family 2 0.0017 0.0055 0.0127
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.005 0.067 0.3522
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0325 0.0311
Schistosoma mansoni glucose transport protein 0.0104 0.1689 0.3882
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0023 0.0178 1
Echinococcus granulosus General substrate transporter 0.009 0.1415 0.3269
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0196 0.3399 0.339
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0073 0.1108 0.256
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0337 0.0779
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.005 0.067 0.1253
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.005 0.067 0.3522
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.005 0.067 0.3522
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0338 0.0617
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0337 0.0337
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0422 0.2189
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.005 0.067 0.152
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0175 0.0308
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0338 0.0617
Echinococcus multilocularis lamin dm0 0.0029 0.0278 0.0643
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.067 0.3522
Echinococcus multilocularis solute carrier family 22 0.0015 0.0014 0.0033
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.1876 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0056 0.0128
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0325 0.072
Plasmodium vivax proline--tRNA ligase, putative 0.0037 0.0422 0.051
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.005 0.067 0.3522
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0246 0.4329 1
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0055 0.0041
Schistosoma mansoni hypothetical protein 0.0104 0.1689 0.3882
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0345 0.1775
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0114 0.1876 1
Schistosoma mansoni hypothetical protein 0.0017 0.0055 0.0094
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.1876 1
Loa Loa (eye worm) hypothetical protein 0.05 0.907 0.907
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0246 0.4329 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.1876 1
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0345 0.1775
Echinococcus granulosus GPCR family 2 0.0017 0.0055 0.0127
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0337 0.0337
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0175 0.0373
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0337 0.0779
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0325 0.1669
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.1876 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.1876 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0104 0.1689 0.3201
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0175 0.0865
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0246 0.4329 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0169 0.289 0.3595
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0056 0.0221
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0325 0.0751
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0056 0.0056
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.005 0.067 0.082
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.005 0.067 0.0657
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0345 0.1775
Schistosoma mansoni protein kinase 0.0032 0.0337 0.0748
Trypanosoma cruzi hexose transporter 0.0032 0.0345 0.1775
Trypanosoma brucei hypothetical protein, conserved 0.005 0.067 0.3522
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0175 0.0201
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.1689 0.3902
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0055 0.0127
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0104 0.1689 0.3902
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0246 0.4329 1
Loa Loa (eye worm) sugar transporter 0.0104 0.1689 0.1689
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.005 0.067 0.3522
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0337 0.0779
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.005 0.067 0.1548
Schistosoma mansoni glucose transport protein 0.0104 0.1689 0.3882
Echinococcus granulosus solute carrier family 22 0.0015 0.0014 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.005 0.067 0.3522
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0345 0.1775
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.1689 0.3902
Entamoeba histolytica protein kinase, putative 0.0032 0.0337 1
Loa Loa (eye worm) PDE1B protein 0.005 0.067 0.067
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0196 0.3399 0.7852
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0338 0.0404
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0278 0.0264
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Plasmodium falciparum proline--tRNA ligase 0.0037 0.0422 0.051
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0056 0.0079
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.005 0.067 0.1548
Giardia lamblia Hypothetical protein 0.005 0.067 0.152
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0114 0.1876 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.005 0.067 0.1253
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.005 0.067 0.3522
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.011 0.5818
Loa Loa (eye worm) hypothetical protein 0.0023 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0025 0.0215 0.0215
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0114 0.1876 1
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0175 0.9816
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0056 0.0221
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0169 0.289 0.3595
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0325 0.0751
Brugia malayi isocitrate dehydrogenase 0.0017 0.0056 0.0041
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.005 0.067 0.1548
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0055 0.0127
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0246 0.4329 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.1876 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0278 0.0278
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.005 0.067 0.0657
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0345 0.1775
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0178 0.0205
Plasmodium vivax hexose transporter 0.0104 0.1689 0.2094
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0114 0.1876 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.005 0.067 0.152
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.005 0.067 0.152
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0091 0.1438 0.7647
Giardia lamblia hypothetical protein 0.005 0.067 0.152
Echinococcus multilocularis solute carrier family 22 0.0015 0.0014 0.0033
Loa Loa (eye worm) hypothetical protein 0.0053 0.0735 0.0735
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.005 0.067 0.3522
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0946 0.5006
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0056 0.0095
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0073 0.1108 0.5875
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Plasmodium falciparum hexose transporter 0.0104 0.1689 0.2094
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0056 0.0221
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0114 0.1876 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0345 0.1775
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0037 0.0422 0.2189
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0014
Plasmodium falciparum phosphodiesterase gamma, putative 0.005 0.067 0.082
Mycobacterium ulcerans putative regulatory protein 0.0023 0.0178 1
Trichomonas vaginalis conserved hypothetical protein 0.0114 0.1876 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.0345 0.1775
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0056 0.0221

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 5.5 Inhibitory activity of the against phosphodiesterase 3 (PDE3); No significant inhibitory activity at pIC50 ChEMBL. 11472206
IC50 (binding) = 7.6 Inhibition of phosphodiesterase 4 (PDE4) in human neutrophils ChEMBL. 11472206
Log IC50 (binding) < 5.5 Inhibitory activity of the against phosphodiesterase 3 (PDE3); No significant inhibitory activity at pIC50 ChEMBL. 11472206
Log IC50 (binding) = 7.6 Inhibition of phosphodiesterase 4 (PDE4) in human neutrophils ChEMBL. 11472206

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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