Detailed information for compound 1391149

Basic information

Technical information
  • TDR Targets ID: 1391149
  • Name: ethyl 6-bromo-5-methoxy-1-methyl-2-[(4-methyl piperidin-1-yl)methyl]indole-3-carboxylate
  • MW: 423.344 | Formula: C20H27BrN2O3
  • H donors: 0 H acceptors: 1 LogP: 4.04 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c2cc(OC)c(cc2n(c1CN1CCC(CC1)C)C)Br
  • InChi: 1S/C20H27BrN2O3/c1-5-26-20(24)19-14-10-18(25-4)15(21)11-16(14)22(3)17(19)12-23-8-6-13(2)7-9-23/h10-11,13H,5-9,12H2,1-4H3
  • InChiKey: WPYHVBPAZAIVNR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 6-bromo-5-methoxy-1-methyl-2-[(4-methyl-1-piperidyl)methyl]indole-3-carboxylate
  • 6-bromo-5-methoxy-1-methyl-2-[(4-methyl-1-piperidinyl)methyl]-3-indolecarboxylic acid ethyl ester
  • 6-bromo-5-methoxy-1-methyl-2-[(4-methyl-1-piperidyl)methyl]indole-3-carboxylic acid ethyl ester
  • A2066/0086912
  • Oprea1_821993
  • ChemDiv1_002986
  • 6-Bromo-5-methoxy-1-methyl-2-(4-methyl-piperidin-1-ylmethyl)-1H-indole-3-carboxylic acid ethyl ester
  • MLS000768937
  • SMR000433639

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni DNA polymerase eta 0.0044 0.0238 0.0213
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0393 0.0538
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0085 0.0588 0.0857
Brugia malayi nuclear receptor NHR-88 0.004 0.0206 0.03
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0085 0.0588 0.0564
Brugia malayi hypothetical protein 0.0025 0.0075 0.0109
Brugia malayi nuclear hormone receptor family member nhr-6 0.004 0.0206 0.03
Brugia malayi nuclear hormone receptor 0.0085 0.0588 0.0857
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0085 0.0588 0.0564
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0085 0.0588 0.0857
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0303 1
Brugia malayi hypothetical protein 0.0045 0.0246 0.0359
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0025 0.5
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0085 0.0588 0.0564
Schistosoma mansoni coup transcription factor 0.0085 0.0588 0.0564
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.0324
Schistosoma mansoni zinc finger protein 0.004 0.0206 0.0181
Loa Loa (eye worm) hypothetical protein 0.0085 0.0588 0.0824
Echinococcus granulosus tar DNA binding protein 0.0062 0.0393 0.0369
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0246 0.023
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0165 0.014
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0393 0.0369
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0264
Echinococcus granulosus ecdysone induced protein 78C 0.0085 0.0588 0.0564
Brugia malayi follicle stimulating hormone receptor 0.028 0.225 0.3281
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0393 0.0573
Brugia malayi nuclear receptor RXR 0.004 0.0206 0.03
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0393 0.0369
Schistosoma mansoni retinoic acid receptor RXR 0.1188 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0045 0.0246 0.0222
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0025 0.5
Brugia malayi tailless protein 0.004 0.0206 0.03
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0206 0.0181
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0303 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.0027 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0246 0.023
Schistosoma mansoni nuclear receptor nhr-48 0.004 0.0206 0.0181
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0264
Loa Loa (eye worm) acetyltransferase 0.0175 0.1357 0.195
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0027 0.0001
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0378 0.0551
Brugia malayi Nuclear hormone receptor E75 0.004 0.0206 0.03
Schistosoma mansoni steroid hormone receptor ad4bp 0.0085 0.0588 0.0564
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0246 0.0359
Schistosoma mansoni hypothetical protein 0.0019 0.0027 0.0001
Brugia malayi Nuclear hormone receptor E75 0.004 0.0206 0.03
Leishmania major DNA polymerase eta, putative 0.0031 0.0127 0.0149
Echinococcus granulosus geminin 0.0166 0.1279 0.1257
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.082 0.6856 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0025 0.5
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0025 0.0082 0.0082
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.082 0.6856 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.004 0.0206 0.0264
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0045 0.0246 0.0222
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0085 0.0588 0.0586
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0085 0.0588 0.0564
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0027 0.0001
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0264
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0264
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0165 0.0145
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0075 0.0072
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0206 0.0181
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.082 0.6856 0.6848
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0085 0.0588 0.0824
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0045 0.0246 0.0222
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0085 0.0588 0.0857
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0075 0.0072
Schistosoma mansoni hypothetical protein 0.0019 0.0027 0.0001
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0085 0.0588 0.0564
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0085 0.0588 0.0564
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0025 0.0082 0.0305
Brugia malayi nuclear hormone receptor family member odr-7 0.004 0.0206 0.03
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0085 0.0588 0.0564
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.0324
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0085 0.0588 0.0857
Plasmodium vivax flap endonuclease 1, putative 0.0025 0.0082 0.0305
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0267 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.004 0.0206 0.0264
Loa Loa (eye worm) RNA binding protein 0.0062 0.0393 0.0538
Brugia malayi hypothetical protein 0.0035 0.0165 0.024
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0264
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.1144 0.9618 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.225 0.3256
Schistosoma mansoni nuclear receptor 0.004 0.0206 0.0181
Brugia malayi steroid hormone receptor 0.0085 0.0588 0.0857
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0303 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0085 0.0588 0.0857
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0027 0.0039
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.004 0.0206 0.03
Brugia malayi orphan nuclear receptor NR2E1 0.004 0.0206 0.03
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0393 0.0538
Schistosoma mansoni hypothetical protein 0.0019 0.0027 0.0001
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0025 0.0082 0.0082
Schistosoma mansoni RAR-like nuclear receptor 0.0085 0.0588 0.0564
Echinococcus multilocularis geminin 0.0166 0.1279 0.1307
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0264
Echinococcus multilocularis thyroid hormone receptor alpha 0.0085 0.0588 0.0586
Brugia malayi Nuclear hormone receptor-like 1 0.0085 0.0588 0.0857
Entamoeba histolytica hypothetical protein 0.0035 0.0165 0.0204
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0085 0.0588 0.0564
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0393 0.0369
Giardia lamblia Flap structure-specific endonuclease 0.0025 0.0082 0.2333
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0025 0.0037
Loa Loa (eye worm) DR-78 0.004 0.0206 0.0264
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0027 0.0039
Schistosoma mansoni nuclear hormone receptor 0.0085 0.0588 0.0564
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0085 0.0588 0.0564
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.0324
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0378 0.0551
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0238 0.0347
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0085 0.0588 0.0564
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0085 0.0588 0.0857
Brugia malayi Steroid receptor seven-up type 2 0.0085 0.0588 0.0857
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0246 0.0221
Echinococcus multilocularis nuclear receptor nhr 48 0.004 0.0206 0.0188
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0085 0.0588 0.0824
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1357 0.1979
Loa Loa (eye worm) hypothetical protein 0.0085 0.0588 0.0824
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0045 0.0246 0.0231
Echinococcus granulosus GPCR family 2 0.0019 0.0027 0.0001
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0264
Brugia malayi hypothetical protein 0.0045 0.0246 0.0359
Brugia malayi nuclear receptor NHR-67 0.004 0.0206 0.03
Brugia malayi nuclear receptor NHR-88 0.0085 0.0588 0.0857
Brugia malayi ecdysteroid receptor 0.0085 0.0588 0.0857
Loa Loa (eye worm) hypothetical protein 0.0085 0.0588 0.0824
Schistosoma mansoni nuclear receptor 0.004 0.0206 0.0181
Brugia malayi Nuclear hormone receptor-like 1 0.0045 0.0246 0.0359
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1357 0.1388
Loa Loa (eye worm) hypothetical protein 0.006 0.0378 0.0516
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0165 0.014
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0025 0.0082 0.0082
Brugia malayi nuclear receptor RXR 0.0045 0.0246 0.0359
Loa Loa (eye worm) hypothetical protein 0.0044 0.0238 0.0311
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0127 0.2286
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.004 0.0206 0.0188
Echinococcus multilocularis ecdysone induced protein 78C 0.0085 0.0588 0.0586
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.082 0.6856 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0085 0.0588 0.0586
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0246 0.0221
Echinococcus multilocularis transcription factor Dp 1 0.0475 0.3911 0.4051
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0127 0.0149
Loa Loa (eye worm) hypothetical protein 0.0085 0.0588 0.0824
Loa Loa (eye worm) hypothetical protein 0.0045 0.0246 0.0324
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0267 0.0353
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1357 0.1335
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0206 0.0188
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0075 0.0072
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0378 0.0516
Onchocerca volvulus Protein ultraspiracle homolog 0.0085 0.0588 1
Brugia malayi TAR-binding protein 0.0062 0.0393 0.0573
Brugia malayi nuclear hormone receptor 0.004 0.0206 0.03
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0085 0.0588 0.0824
Schistosoma mansoni hypothetical protein 0.0035 0.0165 0.014
Loa Loa (eye worm) hypothetical protein 0.0019 0.0027 0.0002
Echinococcus granulosus nuclear receptor nhr 48 0.004 0.0206 0.0181
Schistosoma mansoni thyroid hormone receptor 0.0085 0.0588 0.0564
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.082 0.6856 1
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0238 0.0311
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0264
Loa Loa (eye worm) hypothetical protein 0.0085 0.0588 0.0824
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0085 0.0588 0.0857
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.004 0.0206 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0085 0.0588 0.0857
Onchocerca volvulus 0.0085 0.0588 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0085 0.0588 0.0564
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.082 0.6856 0.6848
Echinococcus granulosus FTZ F1 alpha 0.0085 0.0588 0.0564
Schistosoma mansoni hypothetical protein 0.0041 0.0215 0.019
Entamoeba histolytica hypothetical protein 0.0035 0.0165 0.0204
Echinococcus granulosus thyroid hormone receptor alpha 0.004 0.0206 0.0181
Loa Loa (eye worm) hypothetical protein 0.0085 0.0588 0.0824
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0085 0.0588 0.0824
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.082 0.6856 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0027 0.0001
Echinococcus granulosus transcription factor Dp 1 0.0475 0.3911 0.3896
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0085 0.0588 0.0857
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1315 0.1293
Echinococcus multilocularis flap endonuclease 1 0.0025 0.0082 0.0059
Entamoeba histolytica Flap nuclease, putative 0.0025 0.0082 0.0082
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.082 0.6856 1
Echinococcus granulosus flap endonuclease 1 0.0025 0.0082 0.0056
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0206 0.0188
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0246 0.0221
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0045 0.0246 0.0324
Trichomonas vaginalis flap endonuclease-1, putative 0.0025 0.0082 0.2026
Echinococcus multilocularis FTZ F1 alpha 0.0085 0.0588 0.0586
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0264
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0264
Onchocerca volvulus Bile acid receptor homolog 0.0085 0.0588 1
Schistosoma mansoni thyroid hormone receptor 0.0085 0.0588 0.0564
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0085 0.0588 0.0586
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0085 0.0588 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0085 0.0588 0.0564
Entamoeba histolytica hypothetical protein 0.0035 0.0165 0.0204
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.004 0.0206 0.0181
Entamoeba histolytica hypothetical protein 0.0035 0.0165 0.0204
Echinococcus multilocularis Nuclear hormone receptor HR96 0.004 0.0206 0.0188
Schistosoma mansoni hypothetical protein 0.0019 0.0027 0.0001
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0027 0.0002
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0267 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0027 0.0001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0075 0.0072
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0264
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0238 0.0311
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0303 1
Loa Loa (eye worm) flap endonuclease-1 0.0025 0.0082 0.0082
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0085 0.0588 0.0824
Loa Loa (eye worm) hypothetical protein 0.0041 0.0215 0.0278
Echinococcus multilocularis dna polymerase eta 0.0044 0.0238 0.0222
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0085 0.0588 0.0857
Loa Loa (eye worm) steroid hormone receptor 0.0085 0.0588 0.0824
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0085 0.0588 0.0586
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0246 0.0221
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0246 0.0323
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0085 0.0588 0.0824
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0025 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.004 0.0206 0.0181
Brugia malayi RNA binding protein 0.0062 0.0393 0.0573
Schistosoma mansoni nuclear hormone receptor 0.004 0.0206 0.0181
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0085 0.0588 0.0857
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.004 0.0206 0.0181
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0303 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.082 0.6856 1
Echinococcus granulosus dna polymerase eta 0.0044 0.0238 0.0213
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0246 0.0221
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0264
Plasmodium falciparum flap endonuclease 1 0.0025 0.0082 0.0363
Loa Loa (eye worm) hypothetical protein 0.0085 0.0588 0.0824
Brugia malayi hypothetical protein 0.004 0.0206 0.03
Brugia malayi ecdysone receptor 0.004 0.0206 0.03
Leishmania major DNA polymerase eta, putative 0.0044 0.0238 0.0311
Loa Loa (eye worm) hypothetical protein 0.0085 0.0588 0.0824
Leishmania major hypothetical protein, conserved 0.0025 0.0075 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0085 0.0588 0.0857
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0393 0.0369
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0085 0.0588 0.0586
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0085 0.0588 0.0586
Brugia malayi hypothetical protein 0.004 0.0206 0.03
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0246 0.0359
Schistosoma mansoni hypothetical protein 0.0166 0.1279 0.1257
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0085 0.0588 0.0824
Brugia malayi photoreceptor-specific nuclear receptor 0.0085 0.0588 0.0857
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0085 0.0588 0.0857
Loa Loa (eye worm) nuclear hormone receptor 0.004 0.0206 0.0264
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0215 0.0314
Loa Loa (eye worm) hypothetical protein 0.004 0.0206 0.0264
Brugia malayi Flap endonuclease-1 0.0025 0.0082 0.0119
Schistosoma mansoni flap endonuclease-1 0.0023 0.0061 0.0036
Schistosoma mansoni hypothetical protein 0.0166 0.1279 0.1257
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0393 0.0369
Brugia malayi conserved hypotetical protein 0.004 0.0206 0.03
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.082 0.6856 0.7121
Schistosoma mansoni nuclear hormone receptor 0.004 0.0206 0.0181
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0393 0.0383
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0303 0.0279

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 260 uM PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493224] ChEMBL. No reference
Potency (functional) 6.5733 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 52.1194 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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