Detailed information for compound 1393522

Basic information

Technical information
  • TDR Targets ID: 1393522
  • Name: 5-cyclopropyl-7-(difluoromethyl)-N-(oxolan-2- ylmethyl)pyrazolo[1,5-a]pyrimidine-3-carboxam ide
  • MW: 336.337 | Formula: C16H18F2N4O2
  • H donors: 1 H acceptors: 3 LogP: 1.24 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cnn2c1nc(cc2C(F)F)C1CC1)NCC1CCCO1
  • InChi: 1S/C16H18F2N4O2/c17-14(18)13-6-12(9-3-4-9)21-15-11(8-20-22(13)15)16(23)19-7-10-2-1-5-24-10/h6,8-10,14H,1-5,7H2,(H,19,23)
  • InChiKey: KYVSKINBULNOKW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-cyclopropyl-7-(difluoromethyl)-N-(tetrahydrofuran-2-ylmethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
  • 5-cyclopropyl-7-(difluoromethyl)-N-(2-tetrahydrofuranylmethyl)-3-pyrazolo[1,5-a]pyrimidinecarboxamide
  • 5-cyclopropyl-7-(difluoromethyl)-N-(tetrahydrofurfuryl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
  • STK338627

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0311 1 1
Schistosoma mansoni hypothetical protein 0.0043 0.0934 0.0934
Schistosoma mansoni caspase-7 (C14 family) 0.0083 0.2271 0.2271
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0104 0.2979 0.2979
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1334 0.1334
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0442 0.0442
Trypanosoma brucei Metacaspase-4 0.0043 0.0915 0.2924
Schistosoma mansoni nuclear receptor nhr-48 0.0049 0.112 0.112
Entamoeba histolytica hypothetical protein 0.0043 0.0934 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0104 0.2979 0.2979
Brugia malayi Nuclear hormone receptor E75 0.0049 0.112 0.112
Schistosoma mansoni hypothetical protein 0.004 0.0815 0.0815
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0049 0.112 0.112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0104 0.2979 0.2979
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0104 0.2979 0.2979
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0049 0.112 0.112
Brugia malayi jmjC domain containing protein 0.006 0.1487 0.1487
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0732 1
Onchocerca volvulus Bile acid receptor homolog 0.0104 0.2979 0.3723
Echinococcus multilocularis caspase 0.0113 0.3309 0.3309
Schistosoma mansoni RAR-like nuclear receptor 0.0104 0.2979 0.2979
Loa Loa (eye worm) hypothetical protein 0.0055 0.1319 0.1319
Brugia malayi ecdysteroid receptor 0.0104 0.2979 0.2979
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0934 0.0934
Plasmodium vivax SET domain protein, putative 0.0029 0.0442 0.4828
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0104 0.2979 0.2979
Brugia malayi hypothetical protein 0.004 0.0815 0.0815
Plasmodium vivax metacaspase 1, putative 0.0043 0.0915 1
Schistosoma mansoni thyroid hormone receptor 0.0104 0.2979 0.2979
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0055 0.1319 0.1319
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0732 0.2339
Schistosoma mansoni nuclear hormone receptor 0.0104 0.2979 0.2979
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0915 0.2924
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.023 0.5
Loa Loa (eye worm) hypothetical protein 0.0104 0.2979 0.2979
Onchocerca volvulus 0.0049 0.112 0.0994
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0104 0.2979 0.2979
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0108 0.3131 1
Brugia malayi orphan nuclear receptor NR2E1 0.0049 0.112 0.112
Echinococcus granulosus geminin 0.0164 0.5037 0.5037
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0104 0.2979 0.2979
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.112 0.112
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0311 1 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.023 0.2516
Loa Loa (eye worm) hypothetical protein 0.0055 0.1319 0.1319
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0104 0.2979 0.2979
Echinococcus multilocularis ecdysone induced protein 78C 0.0104 0.2979 0.2979
Echinococcus granulosus caspase 0.0113 0.3309 0.3309
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.023 0.023
Brugia malayi hypothetical protein 0.0049 0.112 0.112
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0311 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0104 0.2979 0.2979
Brugia malayi hypothetical protein 0.0043 0.0934 0.0934
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.733 0.733
Echinococcus granulosus voltage dependent calcium channel 0.0108 0.3131 0.3131
Echinococcus multilocularis caspase 8 0.0043 0.0915 0.0915
Loa Loa (eye worm) hypothetical protein 0.004 0.0815 0.0815
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0104 0.2979 0.3723
Schistosoma mansoni ap endonuclease 0.0023 0.023 0.023
Brugia malayi nuclear hormone receptor family member nhr-6 0.0049 0.112 0.112
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0104 0.2979 0.2979
Loa Loa (eye worm) nuclear receptor NHR-67 0.0049 0.112 0.112
Loa Loa (eye worm) hypothetical protein 0.0041 0.0856 0.0856
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0442 0.0442
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0915 0.0975
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0104 0.2979 0.2979
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0442 0.0442
Loa Loa (eye worm) hypothetical protein 0.006 0.1503 0.1503
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0049 0.112 0.112
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.1348 1
Brugia malayi nuclear receptor NHR-88 0.0104 0.2979 0.2979
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0732 0.0715
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0104 0.2979 0.2979
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0915 0.0975
Schistosoma mansoni inositol monophosphatase 0.0038 0.0732 0.0732
Plasmodium falciparum metacaspase 1 0.0043 0.0915 1
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0915 0.0975
Loa Loa (eye worm) hypothetical protein 0.0055 0.1319 0.1319
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0311 1 1
Schistosoma mansoni nuclear hormone receptor 0.0049 0.112 0.112
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.1348 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0915 0.0975
Plasmodium falciparum metacaspase-like protein 0.0043 0.0915 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.112 0.112
Brugia malayi Inositol-1 0.0038 0.0732 0.0732
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.023 0.0735
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0915 0.2924
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0599 0.5
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0732 0.7136
Loa Loa (eye worm) voltage-dependent calcium channel 0.0108 0.3131 0.3131
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0104 0.2979 0.2979
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.1348 0.1348
Brugia malayi Steroid receptor seven-up type 2 0.0104 0.2979 0.2979
Brugia malayi nuclear receptor RXR 0.0049 0.112 0.112
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0311 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0104 0.2979 0.2979
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0915 0.2924
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.1487 0.1487
Echinococcus granulosus caspase 2 0.0083 0.2271 0.2271
Echinococcus granulosus caspase 8 0.0043 0.0915 0.0915
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0106 0.0106
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0599 0.3301
Trypanosoma cruzi metacaspase, putative 0.0043 0.0915 0.2924
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0915 0.0975
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0915 0.0975
Entamoeba histolytica hypothetical protein 0.0043 0.0934 1
Toxoplasma gondii exonuclease III APE 0.0023 0.023 0.0735
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0732 0.4495
Loa Loa (eye worm) hypothetical protein 0.0108 0.3131 0.3131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0104 0.2979 0.2979
Onchocerca volvulus Protein ultraspiracle homolog 0.0104 0.2979 0.3723
Schistosoma mansoni coup transcription factor 0.0104 0.2979 0.2979
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0104 0.2979 0.2979
Brugia malayi photoreceptor-specific nuclear receptor 0.0104 0.2979 0.2979
Entamoeba histolytica hypothetical protein 0.0043 0.0934 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0104 0.2979 0.2979
Loa Loa (eye worm) hypothetical protein 0.0104 0.2979 0.2979
Onchocerca volvulus 0.023 0.7256 1
Brugia malayi Nuclear hormone receptor E75 0.0049 0.112 0.112
Loa Loa (eye worm) hypothetical protein 0.0019 0.0106 0.0106
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.1348 0.1348
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0732 0.0732
Brugia malayi nuclear hormone receptor family member odr-7 0.0049 0.112 0.112
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.023 0.5
Loa Loa (eye worm) hypothetical protein 0.0104 0.2979 0.2979
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.631 0.631
Trypanosoma cruzi metacaspase, putative 0.0043 0.0915 0.2924
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0055 0.1319 0.1319
Loa Loa (eye worm) hypothetical protein 0.0049 0.112 0.112
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0915 0.0975
Echinococcus granulosus FTZ F1 alpha 0.0104 0.2979 0.2979
Loa Loa (eye worm) DR-78 0.0049 0.112 0.112
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0055 0.1319 0.1319
Echinococcus multilocularis FTZ F1 alpha 0.0104 0.2979 0.2979
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.0815 0.0815
Loa Loa (eye worm) hypothetical protein 0.0049 0.112 0.112
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0442 0.0442
Loa Loa (eye worm) hypothetical protein 0.0104 0.2979 0.2979
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0104 0.2979 0.2979
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1334 0.1334
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0049 0.112 0.112
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0732 0.2339
Echinococcus multilocularis GPCR, family 2 0.0019 0.0106 0.0106
Schistosoma mansoni caspase-7 (C14 family) 0.0113 0.3309 0.3309
Schistosoma mansoni steroid hormone receptor ad4bp 0.0104 0.2979 0.2979
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0049 0.112 0.112
Brugia malayi conserved hypotetical protein 0.0049 0.112 0.112
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0915 0.2924
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.023 0.023
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0732 0.0732
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0043 0.0915 0.0915
Brugia malayi hypothetical protein 0.0055 0.1319 0.1319
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.023 0.0735
Loa Loa (eye worm) hypothetical protein 0.0049 0.112 0.112
Schistosoma mansoni jumonji domain containing protein 0.006 0.1487 0.1487
Brugia malayi nuclear receptor NHR-88 0.0049 0.112 0.112
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0106 0.0106
Brugia malayi Pre-SET motif family protein 0.0202 0.631 0.631
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0732 0.2339
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0732 0.2339
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0104 0.2979 0.2979
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1334 0.1334
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0104 0.2979 0.2979
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0934 0.0934
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0049 0.112 0.112
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0106 0.0106
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.1348 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0732 0.0715
Trypanosoma brucei metacaspase MCA2 0.0043 0.0915 0.2924
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0442 0.0442
Schistosoma mansoni retinoic acid receptor RXR 0.0104 0.2979 0.2979
Schistosoma mansoni hypothetical protein 0.0019 0.0106 0.0106
Echinococcus granulosus caspase 3 0.0071 0.1853 0.1853
Trypanosoma cruzi metacaspase, putative 0.0043 0.0915 0.2924
Loa Loa (eye worm) hypothetical protein 0.0029 0.0442 0.0442
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0915 0.0975
Entamoeba histolytica hypothetical protein 0.0043 0.0934 1
Echinococcus multilocularis voltage dependent calcium channel 0.0311 1 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0915 0.0975
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0106 0.0106
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0856 0.0856
Trypanosoma brucei metacaspase 5, putative 0.0043 0.0915 0.2924
Loa Loa (eye worm) inositol-1 0.0038 0.0732 0.0732
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.0815 0.0815
Loa Loa (eye worm) nuclear hormone receptor 0.0049 0.112 0.112
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.1348 0.1348
Echinococcus multilocularis geminin 0.0164 0.5037 0.5037
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0104 0.2979 0.2979
Schistosoma mansoni ap endonuclease 0.0023 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0104 0.2979 0.2979
Onchocerca volvulus 0.0104 0.2979 0.3723
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.1487 0.1487
Loa Loa (eye worm) hypothetical protein 0.0104 0.2979 0.2979
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.023 0.1709
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0104 0.2979 0.2979
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1503 0.1503
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0104 0.2979 0.2979
Brugia malayi ecdysone receptor 0.0049 0.112 0.112
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1334 0.1334
Onchocerca volvulus 0.004 0.0815 0.0548
Loa Loa (eye worm) hypothetical protein 0.0104 0.2979 0.2979
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1503 0.1503
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0108 0.3131 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0049 0.112 0.0994
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.1319 0.1319
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0311 1 1
Echinococcus granulosus GPCR family 2 0.0019 0.0106 0.0106
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1334 0.1334
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.023 0.023
Schistosoma mansoni thyroid hormone receptor 0.0104 0.2979 0.2979
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0442 0.0442
Toxoplasma gondii transporter, cation channel family protein 0.0108 0.3131 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0732 0.0715
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.1487 0.1487
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0311 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0104 0.2979 0.2979
Brugia malayi Nuclear hormone receptor-like 1 0.0055 0.1319 0.1319
Loa Loa (eye worm) hypothetical protein 0.0049 0.112 0.112
Onchocerca volvulus 0.0049 0.112 0.0994
Brugia malayi hypothetical protein 0.0055 0.1319 0.1319
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0915 0.2924
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0915 0.0975
Schistosoma mansoni caspase-3 (C14 family) 0.0113 0.3309 0.3309
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0915 0.0975
Loa Loa (eye worm) hypothetical protein 0.0049 0.112 0.112
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0104 0.2979 0.2979
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.1487 0.1487
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0113 0.3309 0.3309
Brugia malayi steroid hormone receptor 0.0104 0.2979 0.2979
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1503 0.1503
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0104 0.2979 0.2979
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0049 0.112 0.112
Loa Loa (eye worm) hypothetical protein 0.0083 0.2271 0.2271
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1334 0.1334
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1334 0.1334
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0915 0.0975
Trichomonas vaginalis set domain proteins, putative 0.023 0.7256 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0104 0.2979 0.2979
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.1348 1
Brugia malayi nuclear hormone receptor 0.0104 0.2979 0.2979
Loa Loa (eye worm) hypothetical protein 0.0049 0.112 0.112
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0934 0.0934
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.1221 0.1221
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0104 0.2979 0.2979
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0104 0.2979 0.2979
Schistosoma mansoni nuclear receptor 0.0049 0.112 0.112
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.112 0.112
Toxoplasma gondii hypothetical protein 0.0095 0.2688 0.8586
Brugia malayi jmjC domain containing protein 0.006 0.1487 0.1487
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0095 0.2688 0.2688
Echinococcus multilocularis thyroid hormone receptor alpha 0.0104 0.2979 0.2979
Schistosoma mansoni hypothetical protein 0.0019 0.0106 0.0106
Schistosoma mansoni zinc finger protein 0.0049 0.112 0.112
Schistosoma mansoni nuclear hormone receptor 0.0049 0.112 0.112
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0113 0.3309 0.3309
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0055 0.1319 0.1319
Loa Loa (eye worm) steroid hormone receptor 0.0104 0.2979 0.2979
Loa Loa (eye worm) hypothetical protein 0.0049 0.112 0.112
Schistosoma mansoni inositol monophosphatase 0.0038 0.0732 0.0732
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0915 0.0975
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0055 0.1319 0.1319
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0406 0.0406
Brugia malayi nuclear hormone receptor 0.0049 0.112 0.112
Loa Loa (eye worm) hypothetical protein 0.0043 0.0915 0.0915
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0915 0.0975
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.023 0.023
Leishmania major metacaspase, putative 0.0043 0.0915 0.6793
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.023 0.2516
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0104 0.2979 0.2979
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0442 0.1412
Trypanosoma cruzi metacaspase, putative 0.0043 0.0915 0.2924
Brugia malayi Nuclear hormone receptor-like 1 0.0104 0.2979 0.2979
Schistosoma mansoni hypothetical protein 0.0041 0.0856 0.0856
Echinococcus multilocularis voltage dependent calcium channel 0.0311 1 1
Brugia malayi tailless protein 0.0049 0.112 0.112
Brugia malayi Cell death protein 3 precursor 0.0083 0.2271 0.2271
Brugia malayi hypothetical protein 0.0049 0.112 0.112
Loa Loa (eye worm) hypothetical protein 0.0049 0.112 0.112
Echinococcus granulosus voltage dependent calcium channel 0.0311 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.023 0.0735
Echinococcus granulosus nuclear receptor nhr 48 0.0049 0.112 0.112
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0915 0.0975
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0049 0.112 0.112
Echinococcus multilocularis nuclear receptor nhr 48 0.0049 0.112 0.112
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0104 0.2979 0.2979
Echinococcus granulosus thyroid hormone receptor alpha 0.0049 0.112 0.112
Brugia malayi follicle stimulating hormone receptor 0.0232 0.733 0.733
Echinococcus multilocularis caspase 2 0.0083 0.2271 0.2271
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.1487 0.1487
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0049 0.112 0.112
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1334 0.1334
Loa Loa (eye worm) hypothetical protein 0.0095 0.2688 0.2688
Onchocerca volvulus Cell death protein 3 homolog 0.0083 0.2271 0.2685
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0104 0.2979 0.2979
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1334 0.1334
Loa Loa (eye worm) hypothetical protein 0.0055 0.1319 0.1319
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0442 0.0442
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0732 0.5435
Schistosoma mansoni hypothetical protein 0.0019 0.0106 0.0106
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0915 1
Schistosoma mansoni nuclear receptor 0.0049 0.112 0.112
Trypanosoma brucei metacaspase MCA3 0.0043 0.0915 0.2924
Brugia malayi nuclear receptor RXR 0.0055 0.1319 0.1319
Echinococcus granulosus Nuclear hormone receptor HR96 0.0049 0.112 0.112
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.1348 0.1348
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0104 0.2979 0.2979
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0311 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0104 0.2979 0.2979
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0104 0.2979 0.2979
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0043 0.0915 0.0915
Schistosoma mansoni hypothetical protein 0.0164 0.5037 0.5037
Loa Loa (eye worm) hypothetical protein 0.0049 0.112 0.112
Loa Loa (eye worm) hypothetical protein 0.0049 0.112 0.112
Loa Loa (eye worm) calcium channel 0.0311 1 1
Schistosoma mansoni hypothetical protein 0.0164 0.5037 0.5037
Loa Loa (eye worm) hypothetical protein 0.0055 0.1319 0.1319
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0049 0.112 0.0994
Echinococcus granulosus Nuclear hormone receptor HR96 0.0049 0.112 0.112
Loa Loa (eye worm) hypothetical protein 0.0049 0.112 0.112
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0104 0.2979 0.2979
Brugia malayi Pre-SET motif family protein 0.0029 0.0442 0.0442
Loa Loa (eye worm) hypothetical protein 0.0104 0.2979 0.2979
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0106 0.0106
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0311 1 1
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0311 1 1
Trypanosoma brucei metacaspase 0.0043 0.0915 0.2924
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0106 0.0106
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0104 0.2979 0.2979
Schistosoma mansoni hypothetical protein 0.0019 0.0106 0.0106
Echinococcus granulosus ecdysone induced protein 78C 0.0104 0.2979 0.2979
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.1487 0.1487
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.1487 0.1487
Brugia malayi nuclear receptor NHR-67 0.0049 0.112 0.112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0104 0.2979 0.2979
Echinococcus multilocularis caspase 3 0.0071 0.1853 0.1853
Schistosoma mansoni voltage-gated cation channel 0.0311 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0104 0.2979 0.2979
Loa Loa (eye worm) hypothetical protein 0.0049 0.112 0.112

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.003 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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