TDR Targets

Basic information

Technical information

TDR Targets ID: 1393522
Name: 5-cyclopropyl-7-(difluoromethyl)-N-(oxolan-2- ylmethyl)pyrazolo[1,5-a]pyrimidine-3-carboxam ide
MW: 336.337 | Formula: C16H18F2N4O2
H donors: 1 H acceptors: 3 LogP: 1.24 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cnn2c1nc(cc2C(F)F)C1CC1)NCC1CCCO1
InChi: 1S/C16H18F2N4O2/c17-14(18)13-6-12(9-3-4-9)21-15-11(8-20-22(13)15)16(23)19-7-10-2-1-5-24-10/h6,8-10,14H,1-5,7H2,(H,19,23)
InChiKey: KYVSKINBULNOKW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-cyclopropyl-7-(difluoromethyl)-N-(tetrahydrofuran-2-ylmethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
5-cyclopropyl-7-(difluoromethyl)-N-(2-tetrahydrofuranylmethyl)-3-pyrazolo[1,5-a]pyrimidinecarboxamide
5-cyclopropyl-7-(difluoromethyl)-N-(tetrahydrofurfuryl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
STK338627

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	jumonji domain containing protein	0.006	0.1487	0.1487
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0043	0.0915	0.0975
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0043	0.0915	0.0975
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0915	0.0915
Loa Loa (eye worm)	calcium channel	0.0311	1	1
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0106	0.0106
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1334	0.1334
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2688	0.2688
Trypanosoma cruzi	metacaspase 5, putative	0.0043	0.0915	0.2924
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0732	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0104	0.2979	0.2979
Trypanosoma brucei	Metacaspase-4	0.0043	0.0915	0.2924
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0104	0.2979	0.2979
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0049	0.112	0.112
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0732	0.2339
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0104	0.2979	0.2979
Loa Loa (eye worm)	hypothetical protein	0.0095	0.2688	0.2688
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0106	0.0106
Echinococcus multilocularis	caspase 8	0.0043	0.0915	0.0915
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1334	0.1334
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0311	1	1
Brugia malayi	follicle stimulating hormone receptor	0.0232	0.733	0.733
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1334	0.1334
Schistosoma mansoni	caspase-3 (C14 family)	0.0113	0.3309	0.3309
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0915	0.0975
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0023	0.023	0.5
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0104	0.2979	0.2979
Schistosoma mansoni	thyroid hormone receptor	0.0104	0.2979	0.2979
Trypanosoma cruzi	metacaspase, putative	0.0043	0.0915	0.2924
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.1503	0.1503
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.023	0.023
Plasmodium vivax	SET domain protein, putative	0.0029	0.0442	0.4828
Echinococcus granulosus	thyroid hormone receptor alpha	0.0049	0.112	0.112
Brugia malayi	Nuclear hormone receptor E75	0.0049	0.112	0.112
Brugia malayi	Cell death protein 3 precursor	0.0083	0.2271	0.2271
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0104	0.2979	0.2979
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0049	0.112	0.112
Schistosoma mansoni	hypothetical protein	0.0019	0.0106	0.0106
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0442	0.0442
Schistosoma mansoni	retinoic acid receptor RXR	0.0104	0.2979	0.2979
Loa Loa (eye worm)	hypothetical protein	0.004	0.0815	0.0815
Loa Loa (eye worm)	hypothetical protein	0.0104	0.2979	0.2979
Echinococcus granulosus	ecdysone induced protein 78C	0.0104	0.2979	0.2979
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0038	0.0732	1
Toxoplasma gondii	hypothetical protein	0.0095	0.2688	0.8586
Onchocerca volvulus	Cell death protein 3 homolog	0.0083	0.2271	0.2685
Echinococcus multilocularis	voltage dependent calcium channel	0.0311	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0104	0.2979	0.2979
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0104	0.2979	0.2979
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0023	0.023	0.0735
Trypanosoma cruzi	metacaspase, putative	0.0043	0.0915	0.2924
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0056	0.1348	0.1348
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0442	0.0442
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0442	0.0442
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0038	0.0732	0.4495
Schistosoma mansoni	caspase-7 (C14 family)	0.0083	0.2271	0.2271
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.023	0.023
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0915	0.0975
Loa Loa (eye worm)	hypothetical protein	0.0108	0.3131	0.3131
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0023	0.023	0.5
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0106	0.0106
Trypanosoma brucei	metacaspase MCA3	0.0043	0.0915	0.2924
Brugia malayi	Pre-SET motif family protein	0.0029	0.0442	0.0442
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0442	0.1412
Echinococcus multilocularis	caspase	0.0113	0.3309	0.3309
Trypanosoma brucei	metacaspase 5, putative	0.0043	0.0915	0.2924
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0406	0.0406
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0442	0.0442
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0915	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0055	0.1319	0.1319
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0049	0.112	0.112
Schistosoma mansoni	nuclear receptor	0.0049	0.112	0.112
Schistosoma mansoni	nuclear hormone receptor	0.0049	0.112	0.112
Toxoplasma gondii	exonuclease III APE	0.0023	0.023	0.0735
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1334	0.1334
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0052	0.1221	0.1221
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0108	0.3131	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0104	0.2979	0.2979
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0104	0.2979	0.2979
Loa Loa (eye worm)	hypothetical protein	0.0049	0.112	0.112
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0311	1	1
Brugia malayi	steroid hormone receptor	0.0104	0.2979	0.2979
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0049	0.112	0.112
Brugia malayi	mucosa associated lymphoid tissue lymphoma translocation protein 1	0.0043	0.0915	0.0915
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.023	0.023
Echinococcus granulosus	apoptotic protease activating factor 1	0.004	0.0815	0.0815
Plasmodium falciparum	metacaspase 1	0.0043	0.0915	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0104	0.2979	0.2979
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0856	0.0856
Entamoeba histolytica	hypothetical protein	0.0043	0.0934	1
Brugia malayi	hypothetical protein	0.0055	0.1319	0.1319
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0232	0.733	0.733
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0056	0.1348	0.1348
Echinococcus granulosus	voltage dependent calcium channel	0.0108	0.3131	0.3131
Brugia malayi	nuclear receptor NHR-67	0.0049	0.112	0.112
Schistosoma mansoni	hypothetical protein	0.004	0.0815	0.0815
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0104	0.2979	0.2979
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0106	0.0106
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0104	0.2979	0.2979
Loa Loa (eye worm)	hypothetical protein	0.0049	0.112	0.112
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0311	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0104	0.2979	0.2979
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0104	0.2979	0.2979
Brugia malayi	nuclear receptor NHR-88	0.0049	0.112	0.112
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0104	0.2979	0.2979
Loa Loa (eye worm)	hypothetical protein	0.0104	0.2979	0.2979
Loa Loa (eye worm)	hypothetical protein	0.0049	0.112	0.112
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0104	0.2979	0.2979
Echinococcus granulosus	FTZ F1 alpha	0.0104	0.2979	0.2979
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.006	0.1487	0.1487
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1319	0.1319
Echinococcus multilocularis	voltage dependent calcium channel	0.0311	1	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.112	0.112
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0104	0.2979	0.2979
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.1487	0.1487
Brugia malayi	nuclear hormone receptor	0.0049	0.112	0.112
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1319	0.1319
Schistosoma mansoni	voltage-gated cation channel	0.0311	1	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0055	0.1319	0.1319
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1334	0.1334
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0732	0.0732
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1319	0.1319
Schistosoma mansoni	nuclear hormone receptor	0.0104	0.2979	0.2979
Brugia malayi	nuclear receptor RXR	0.0049	0.112	0.112
Schistosoma mansoni	jumonji/arid domain-containing protein	0.006	0.1487	0.1487
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0104	0.2979	0.2979
Echinococcus granulosus	GPCR family 2	0.0019	0.0106	0.0106
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0104	0.2979	0.2979
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0915	0.0975
Echinococcus multilocularis	lysine specific demethylase 5A	0.006	0.1487	0.1487
Loa Loa (eye worm)	hypothetical protein	0.0104	0.2979	0.2979
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0442	0.0442
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0023	0.023	0.0735
Brugia malayi	tailless protein	0.0049	0.112	0.112
Schistosoma mansoni	coup transcription factor	0.0104	0.2979	0.2979
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0104	0.2979	0.2979
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0104	0.2979	0.2979
Loa Loa (eye worm)	nuclear hormone receptor	0.0049	0.112	0.112
Schistosoma mansoni	hypothetical protein	0.0164	0.5037	0.5037
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0049	0.112	0.112
Schistosoma mansoni	thyroid hormone receptor	0.0104	0.2979	0.2979
Loa Loa (eye worm)	hypothetical protein	0.006	0.1503	0.1503
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0442	0.0442
Brugia malayi	Nuclear hormone receptor E75	0.0049	0.112	0.112
Entamoeba histolytica	hypothetical protein	0.0043	0.0934	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.112	0.112
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0915	0.0975
Echinococcus granulosus	geminin	0.0164	0.5037	0.5037
Loa Loa (eye worm)	hypothetical protein	0.0049	0.112	0.112
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0104	0.2979	0.2979
Brugia malayi	conserved hypotetical protein	0.0049	0.112	0.112
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0104	0.2979	0.2979
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0311	1	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.112	0.112
Brugia malayi	nuclear hormone receptor family member odr-7	0.0049	0.112	0.112
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0104	0.2979	0.2979
Onchocerca volvulus		0.004	0.0815	0.0548
Loa Loa (eye worm)	jmjC domain-containing protein	0.006	0.1487	0.1487
Schistosoma mansoni	nuclear receptor	0.0049	0.112	0.112
Schistosoma mansoni	hypothetical protein	0.0043	0.0934	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0104	0.2979	0.2979
Trypanosoma cruzi	metacaspase, putative	0.0043	0.0915	0.2924
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0442	0.0442
Echinococcus granulosus	inositol monophosphatase 1	0.0038	0.0732	0.0732
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0732	0.0715
Brugia malayi	ecdysteroid receptor	0.0104	0.2979	0.2979
Onchocerca volvulus	Protein ultraspiracle homolog	0.0104	0.2979	0.3723
Echinococcus multilocularis	ecdysone induced protein 78C	0.0104	0.2979	0.2979
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.1334	0.1334
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1334	0.1334
Echinococcus granulosus	caspase 2	0.0083	0.2271	0.2271
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0311	1	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0104	0.2979	0.2979
Brugia malayi	nuclear receptor NHR-88	0.0104	0.2979	0.2979
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0856	0.0856
Onchocerca volvulus		0.023	0.7256	1
Echinococcus granulosus	lysine specific demethylase 5A	0.006	0.1487	0.1487
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0055	0.1319	0.1319
Echinococcus granulosus	caspase 8	0.0043	0.0915	0.0915
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0043	0.0915	0.2924
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0104	0.2979	0.2979
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0108	0.3131	0.3131
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1319	0.1319
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0043	0.0915	0.0975
Brugia malayi	Steroid receptor seven-up type 2	0.0104	0.2979	0.2979
Echinococcus granulosus	caspase 3	0.0071	0.1853	0.1853
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.1503	0.1503
Echinococcus multilocularis	caspase 3, apoptosis cysteine peptidase	0.0113	0.3309	0.3309
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0732	0.2339
Brugia malayi	hypothetical protein	0.0049	0.112	0.112
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.1348	0.1348
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0055	0.1319	0.1319
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0106	0.0106
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0104	0.2979	0.2979
Echinococcus granulosus	caspase 3 apoptosis cysteine peptidase	0.0113	0.3309	0.3309
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.1348	1
Brugia malayi	hypothetical protein	0.0055	0.1319	0.1319
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0038	0.0732	0.7136
Onchocerca volvulus	Bile acid receptor homolog	0.0104	0.2979	0.3723
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0732	0.2339
Echinococcus multilocularis	caspase 3	0.0071	0.1853	0.1853
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0106	0.0106
Brugia malayi	Pre-SET motif family protein	0.0202	0.631	0.631
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0311	1	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0856	0.0856
Echinococcus multilocularis	FTZ F1 alpha	0.0104	0.2979	0.2979
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0106	0.0106
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0056	0.1348	0.1348
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0023	0.023	0.1709
Echinococcus multilocularis	inositol monophosphatase 1	0.0038	0.0732	0.0732
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0049	0.112	0.112
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0311	1	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0934	0.0934
Brugia malayi	jmjC domain containing protein	0.006	0.1487	0.1487
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0043	0.0915	0.0975
Trypanosoma cruzi	metacaspase, putative	0.0043	0.0915	0.2924
Plasmodium falciparum	metacaspase-like protein	0.0043	0.0915	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0104	0.2979	0.2979
Schistosoma mansoni	hypothetical protein	0.0164	0.5037	0.5037
Loa Loa (eye worm)	hypothetical protein	0.0049	0.112	0.112
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0311	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0915	0.0975
Loa Loa (eye worm)	inositol-1	0.0038	0.0732	0.0732
Echinococcus granulosus	nuclear receptor nhr 48	0.0049	0.112	0.112
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.023	0.023
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0055	0.1319	0.1319
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0043	0.0915	0.0975
Brugia malayi	orphan nuclear receptor NR2E1	0.0049	0.112	0.112
Trichomonas vaginalis	inositol monophosphatase, putative	0.0038	0.0732	0.0715
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0049	0.112	0.0994
Trichomonas vaginalis	set domain proteins, putative	0.023	0.7256	1
Brugia malayi	jmjC domain containing protein	0.006	0.1487	0.1487
Schistosoma mansoni	nuclear receptor nhr-48	0.0049	0.112	0.112
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0034	0.0599	0.5
Loa Loa (eye worm)	hypothetical protein	0.0104	0.2979	0.2979
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0104	0.2979	0.2979
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0104	0.2979	0.2979
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0049	0.112	0.112
Schistosoma mansoni	ap endonuclease	0.0023	0.023	0.023
Schistosoma mansoni	hypothetical protein	0.0019	0.0106	0.0106
Brugia malayi	Nuclear hormone receptor-like 1	0.0055	0.1319	0.1319
Leishmania major	metacaspase, putative	0.0043	0.0915	0.6793
Brugia malayi	Nuclear hormone receptor-like 1	0.0104	0.2979	0.2979
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0934	0.0934
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0049	0.112	0.0994
Brugia malayi	hypothetical protein	0.0043	0.0934	0.0934
Echinococcus multilocularis	caspase 2	0.0083	0.2271	0.2271
Brugia malayi	hypothetical protein	0.0049	0.112	0.112
Brugia malayi	nuclear hormone receptor	0.0104	0.2979	0.2979
Trypanosoma cruzi	metacaspase 5, putative	0.0043	0.0915	0.2924
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0104	0.2979	0.2979
Loa Loa (eye worm)	hypothetical protein	0.0104	0.2979	0.2979
Entamoeba histolytica	hypothetical protein	0.0043	0.0934	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.631	0.631
Echinococcus multilocularis	nuclear receptor nhr 48	0.0049	0.112	0.112
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0049	0.112	0.112
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0732	0.0715
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0104	0.2979	0.2979
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0104	0.2979	0.2979
Brugia malayi	hypothetical protein	0.004	0.0815	0.0815
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0043	0.0915	0.2924
Onchocerca volvulus		0.0049	0.112	0.0994
Onchocerca volvulus		0.0049	0.112	0.0994
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0934	0.0934
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0049	0.112	0.112
Trypanosoma brucei	metacaspase MCA2	0.0043	0.0915	0.2924
Loa Loa (eye worm)	steroid hormone receptor	0.0104	0.2979	0.2979
Brugia malayi	Inositol-1	0.0038	0.0732	0.0732
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0104	0.2979	0.2979
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0104	0.2979	0.2979
Echinococcus granulosus	voltage dependent calcium channel	0.0311	1	1
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0106	0.0106
Toxoplasma gondii	transporter, cation channel family protein	0.0108	0.3131	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0104	0.2979	0.2979
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0311	1	1
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0043	0.0915	0.0975
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0056	0.1348	1
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0915	0.0975
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0049	0.112	0.112
Schistosoma mansoni	ap endonuclease	0.0023	0.023	0.023
Loa Loa (eye worm)	hypothetical protein	0.0049	0.112	0.112
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0104	0.2979	0.2979
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0049	0.112	0.112
Schistosoma mansoni	zinc finger protein	0.0049	0.112	0.112
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0104	0.2979	0.2979
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.1334	0.1334
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0104	0.2979	0.2979
Loa Loa (eye worm)	hypothetical protein	0.0104	0.2979	0.2979
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0049	0.112	0.112
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0056	0.1348	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0442	0.0442
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0106	0.0106
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0043	0.0915	0.0975
Entamoeba histolytica	hypothetical protein	0.0043	0.0934	1
Plasmodium vivax	metacaspase 1, putative	0.0043	0.0915	1
Toxoplasma gondii	ICE family protease (caspase) p20 domain-containing protein	0.0043	0.0915	0.2924
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0104	0.2979	0.2979
Loa Loa (eye worm)	DR-78	0.0049	0.112	0.112
Loa Loa (eye worm)	hypothetical protein	0.0049	0.112	0.112
Loa Loa (eye worm)	hypothetical protein	0.0049	0.112	0.112
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0049	0.112	0.112
Schistosoma mansoni	nuclear hormone receptor	0.0049	0.112	0.112
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0104	0.2979	0.2979
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0049	0.112	0.112
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0049	0.112	0.112
Loa Loa (eye worm)	hypothetical protein	0.0311	1	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1334	0.1334
Loa Loa (eye worm)	hypothetical protein	0.0049	0.112	0.112
Trypanosoma brucei	metacaspase	0.0043	0.0915	0.2924
Echinococcus granulosus	caspase	0.0113	0.3309	0.3309
Echinococcus multilocularis	apoptotic protease activating factor 1	0.004	0.0815	0.0815
Brugia malayi	nuclear receptor RXR	0.0055	0.1319	0.1319
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1319	0.1319
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0108	0.3131	1
Brugia malayi	ecdysone receptor	0.0049	0.112	0.112
Echinococcus multilocularis	geminin	0.0164	0.5037	0.5037
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.023	0.2516
Schistosoma mansoni	RAR-like nuclear receptor	0.0104	0.2979	0.2979
Schistosoma mansoni	hypothetical protein	0.0019	0.0106	0.0106
Schistosoma mansoni	caspase-7 (C14 family)	0.0113	0.3309	0.3309
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0043	0.0915	0.0975
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0023	0.023	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0083	0.2271	0.2271
Loa Loa (eye worm)	hypothetical protein	0.0049	0.112	0.112
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0056	0.1348	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0106	0.0106
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0023	0.023	0.2516
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0104	0.2979	0.2979
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.1503	0.1503
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0104	0.2979	0.2979
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.006	0.1487	0.1487
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0104	0.2979	0.3723
Onchocerca volvulus		0.0104	0.2979	0.3723
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0038	0.0732	0.2339
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0732	0.5435
Brugia malayi	Nuclear hormone receptor-like 1	0.0055	0.1319	0.1319
Trichomonas vaginalis	Clan CD, family C14, metacaspase-like cysteine peptidase	0.0043	0.0915	0.0975
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0034	0.0599	0.3301
Schistosoma mansoni	subfamily C14A unassigned peptidase (C14 family)	0.0043	0.0915	0.0915

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.2387 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.003 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	16.3601 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1526485

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1393522