Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-30 | 0.0174 | 0.1234 | 0.1249 |
Loa Loa (eye worm) | FKBP5 protein | 0.1265 | 0.9879 | 1 |
Giardia lamblia | FKBP-type peptidyl-prolyl cis-trans isomerase | 0.1265 | 0.9879 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1094 | 0.8523 | 0.8628 |
Onchocerca volvulus | 0.0177 | 0.1258 | 1 | |
Toxoplasma gondii | peptidyl-prolyl isomerase FKBP12, putative | 0.0174 | 0.1234 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0174 | 0.1234 | 0.5 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0174 | 0.1234 | 0.5 |
Leishmania major | FKBP-type peptidyl-prolyl cis-trans isomerase, putative | 0.0174 | 0.1234 | 0.1249 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.1265 | 0.9879 | 1 |
Schistosoma mansoni | immunophilin | 0.128 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0174 | 0.1234 | 0.1249 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0174 | 0.1234 | 0.5 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 | 0.1268 | 0.9903 | 1 |
Mycobacterium leprae | PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG | 0.0174 | 0.1234 | 0.5 |
Schistosoma mansoni | fk506 binding protein | 0.0174 | 0.1234 | 0.1234 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-33 | 0.0174 | 0.1234 | 0.1249 |
Schistosoma mansoni | immunophilin FK506 binding protein FKBP12 | 0.1265 | 0.9879 | 0.9879 |
Trypanosoma brucei | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1265 | 0.9879 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.1106 | 0.8621 | 0.8621 |
Leishmania major | fk506-binding protein 1-like protein | 0.1265 | 0.9879 | 1 |
Trichomonas vaginalis | fk506 binding protein, putative | 0.0174 | 0.1234 | 0.1249 |
Echinococcus multilocularis | fk506 binding protein | 0.1265 | 0.9879 | 0.9879 |
Giardia lamblia | 70 kDa peptidylprolyl isomerase, putative | 0.1265 | 0.9879 | 1 |
Echinococcus granulosus | FK506 binding protein 2 | 0.0174 | 0.1234 | 0.1234 |
Trichomonas vaginalis | immunophilin, putative | 0.1265 | 0.9879 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-13 | 0.0174 | 0.1234 | 0.1249 |
Mycobacterium tuberculosis | Probable trigger factor (TF) protein Tig | 0.0174 | 0.1234 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0174 | 0.1234 | 0.1249 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type , putative | 0.128 | 1 | 1 |
Loa Loa (eye worm) | FKBP-type peptidyl-prolyl cis-trans isomerase-12 | 0.1265 | 0.9879 | 1 |
Leishmania major | peptidylprolyl isomerase-like protein | 0.1265 | 0.9879 | 1 |
Mycobacterium ulcerans | FK-506 binding protein, peptidyl-prolyl cis-trans isomerase | 0.1265 | 0.9879 | 1 |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase FKBP35 | 0.1265 | 0.9879 | 1 |
Trypanosoma brucei | macrophage infectivity potentiator, precursor, putative | 0.0174 | 0.1234 | 0.1249 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0174 | 0.1234 | 0.1249 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP1A | 0.1265 | 0.9879 | 0.9879 |
Onchocerca volvulus | 0.0174 | 0.1234 | 0.9809 | |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.1234 | 0.1249 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.1265 | 0.9879 | 1 |
Plasmodium vivax | 70 kDa peptidylprolyl isomerase, putative | 0.1265 | 0.9879 | 1 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1265 | 0.9879 | 1 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, putative | 0.0174 | 0.1234 | 0.1249 |
Toxoplasma gondii | peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein | 0.0174 | 0.1234 | 0.5 |
Chlamydia trachomatis | peptidyl-prolyl cis-trans isomerase | 0.0174 | 0.1234 | 0.5 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0174 | 0.1234 | 0.1249 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1265 | 0.9879 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.1234 | 0.1234 |
Echinococcus granulosus | peptidyl prolyl cis trans isomerase FKBP4 | 0.1106 | 0.8621 | 0.8621 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1265 | 0.9879 | 1 |
Brugia malayi | FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 | 0.1265 | 0.9879 | 0.9972 |
Echinococcus multilocularis | 0.0174 | 0.1234 | 0.1234 | |
Wolbachia endosymbiont of Brugia malayi | FKBP-type peptidylprolyl isomerase | 0.0174 | 0.1234 | 0.5 |
Treponema pallidum | peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) | 0.1265 | 0.9879 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase, putative | 0.0174 | 0.1234 | 0.1249 |
Schistosoma mansoni | immunophilin | 0.128 | 1 | 1 |
Echinococcus granulosus | FK506 binding protein 8 38 kDa | 0.0174 | 0.1234 | 0.1234 |
Trypanosoma cruzi | FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative | 0.1265 | 0.9879 | 1 |
Echinococcus multilocularis | peptidyl prolyl cis trans isomerase FKBP4 | 0.128 | 1 | 1 |
Trichomonas vaginalis | fk506-binding protein, putative | 0.0174 | 0.1234 | 0.1249 |
Leishmania major | peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative | 0.0174 | 0.1234 | 0.1249 |
Schistosoma mansoni | immunophilin | 0.1106 | 0.8621 | 0.8621 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase, putative | 0.1265 | 0.9879 | 1 |
Trichomonas vaginalis | peptidylprolyl isomerase, putative | 0.1265 | 0.9879 | 1 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, FKBP-type, putative | 0.128 | 1 | 1 |
Trypanosoma brucei | FKBP-type peptidylprolyl cis-trans isomerase, putative | 0.0174 | 0.1234 | 0.1249 |
Echinococcus multilocularis | FK506 binding protein 8, 38 kDa | 0.0189 | 0.1355 | 0.1355 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 62.3 uM | PUBCHEM_BIOASSAY: SAR analysis of Antagonists of XIAP-Bir3 domain of IAP-family anti-apoptotic proteins. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1018, AID1449, AID1513, AID1514, AID1638] | ChEMBL. | No reference |
IC50 (binding) | > 100 uM | PUBCHEM_BIOASSAY: SAR analysis of Antagonists of IAP-family anti-apoptotic proteins. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1018, AID1449, AID1513, AID1514, AID1638] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.