Detailed information for compound 1394044

Basic information

Technical information
  • TDR Targets ID: 1394044
  • Name: (2-bromophenyl)methyl 2-[[2-(furan-2-carbonyl amino)acetyl]amino]acetate
  • MW: 395.205 | Formula: C16H15BrN2O5
  • H donors: 2 H acceptors: 3 LogP: 2.05 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(OCc1ccccc1Br)CNC(=O)CNC(=O)c1ccco1
  • InChi: 1S/C16H15BrN2O5/c17-12-5-2-1-4-11(12)10-24-15(21)9-18-14(20)8-19-16(22)13-6-3-7-23-13/h1-7H,8-10H2,(H,18,20)(H,19,22)
  • InChiKey: XQDYKZCZJDCREN-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • 2-[[2-[(2-furyl-oxomethyl)amino]-1-oxoethyl]amino]acetic acid (2-bromophenyl)methyl ester
  • 2-[[2-(furan-2-carbonylamino)acetyl]amino]acetic acid (2-bromobenzyl) ester
  • (2-bromophenyl)methyl 2-[2-(furan-2-ylcarbonylamino)ethanoylamino]ethanoate
  • SMR000081919
  • 2-bromobenzyl N-2-furoylglycylglycinate
  • MLS000052487
  • ZINC02881165

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens karyopherin (importin) beta 1 No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0037 0.0056 0.0129
Loa Loa (eye worm) hypothetical protein 0.046 0.5461 0.92
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0037 0.0056 0.0129
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0037 0.0056 0.0095
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0037 0.0056 0.0129
Loa Loa (eye worm) hypothetical protein 0.0035 0.0027 0.0045
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0497 0.5935 0.5935
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0056 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0037 0.0056 0.0129
Echinococcus multilocularis snurportin 1 0.0372 0.4334 1
Loa Loa (eye worm) hypothetical protein 0.0497 0.5935 1
Onchocerca volvulus 0.0033 0 0.5
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0037 0.0056 0.0129
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0497 0.5935 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0037 0.0056 0.0129
Leishmania major hypothetical protein, conserved 0.0037 0.0056 0.5
Leishmania major cAMP-specific phosphodiesterase, putative 0.0037 0.0056 0.5
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0037 0.0056 0.0056
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0037 0.0056 0.0095
Schistosoma mansoni hypothetical protein 0.0372 0.4334 0.4334
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0288 0.0485
Echinococcus granulosus importin subunit beta 1 0.0035 0.0027 0.0062
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0027 0.0062
Schistosoma mansoni importin beta-1 0.0035 0.0027 0.0027
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0056 0.5
Leishmania major hypothetical protein, conserved 0.0037 0.0056 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0056 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0056 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0037 0.0056 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0288 0.0664
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0037 0.0056 0.0056
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0037 0.0056 0.0056
Echinococcus granulosus snurportin 1 0.0372 0.4334 1
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0288 0.0288
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0027 0.4771
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0037 0.0056 0.0129
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0288 0.0485
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0056 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0095
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0056 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0497 0.5935 1
Giardia lamblia Hypothetical protein 0.0037 0.0056 0.5
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0037 0.0056 0.0129
Plasmodium vivax phosphodiesterase gamma, putative 0.0037 0.0056 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0288 0.0664
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0056 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0037 0.0056 0.0056
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Loa Loa (eye worm) hypothetical protein 0.046 0.5461 0.92
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0056 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0037 0.0056 0.0129
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0056 0.5
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0037 0.0056 0.0129
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0037 0.0056 0.0129
Loa Loa (eye worm) PDE1B protein 0.0037 0.0056 0.0095
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0095
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0037 0.0056 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0037 0.0056 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0037 0.0056 0.0056
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0037 0.0056 0.0056
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0056 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0037 0.0056 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0056 1
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0056 1
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0037 0.0056 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0056 0.5
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0037 0.0056 0.5
Plasmodium falciparum importin beta, putative 0.0035 0.0027 0.4771
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0037 0.0056 0.0129
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0037 0.0056 0.0129
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0037 0.0056 0.0056
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0037 0.0056 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0037 0.0056 0.0129
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0037 0.0056 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0056 1
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0037 0.0056 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0037 0.0056 0.0129
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0037 0.0056 0.0056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0288 0.0288
Plasmodium falciparum phosphodiesterase gamma, putative 0.0037 0.0056 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0288 0.0664
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0037 0.0056 0.0095
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0037 0.0056 0.0095
Loa Loa (eye worm) hypothetical protein 0.046 0.5461 0.92
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0056 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0056 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0037 0.0056 0.0056
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0037 0.0056 0.5
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0037 0.0056 0.5
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0056 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0056 1
Brugia malayi Importin beta-1 subunit 0.0035 0.0027 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0056 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0056 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0037 0.0056 0.0056
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.4334 0.7302
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0056 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0056 1
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0037 0.0056 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0056 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0056 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0037 0.0056 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0056 1
Giardia lamblia hypothetical protein 0.0037 0.0056 0.5
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0037 0.0056 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0056 1
Plasmodium vivax importin-beta 2, putative 0.0035 0.0027 0.4771
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0288 0.0288
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Onchocerca volvulus 0.0033 0 0.5
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0037 0.0056 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0037 0.0056 0.5
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0037 0.0056 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0288 0.0664
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0037 0.0056 0.5
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0056 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0037 0.0056 0.0095
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0037 0.0056 1
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Brugia malayi RNA, U transporter 1 0.0099 0.0848 0.1428
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0037 0.0056 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.0056 0.0095
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0037 0.0056 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0037 0.0056 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0037 0.0056 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0037 0.0056 0.0129

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.4581 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 1.9953 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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