Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lysine (K)-specific demethylase 4E | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Bacillus subtilis (strain 168) | ATP-dependent Clp protease proteolytic subunit | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.9662 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0131 | 0.0131 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 0.0685 | 0.2309 |
Schistosoma mansoni | jumonji domain containing protein | 0.0071 | 0.0685 | 0.2309 |
Mycobacterium tuberculosis | Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) | 0.0076 | 0.0919 | 0.0671 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0124 | 0.2968 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0131 | 0.044 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.1702 | 0.5 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0094 | 0.1702 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0071 | 0.0685 | 0.2309 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0062 | 0.0289 | 0.0289 |
Echinococcus granulosus | divalent metal transporter DMT1B | 0.0124 | 0.2968 | 0.2968 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0094 | 0.1702 | 0.1702 |
Brugia malayi | NRAMP-like transporter K11G12.4 | 0.0124 | 0.2968 | 0.2968 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0062 | 0.0289 | 0.0289 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0094 | 0.1702 | 0.1702 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.1702 | 0.5 |
Echinococcus multilocularis | divalent metal transporter DMT1B | 0.0124 | 0.2968 | 0.2968 |
Toxoplasma gondii | divalent metal transporter, putative | 0.0124 | 0.2968 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0094 | 0.1702 | 0.1702 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0071 | 0.0685 | 0.0685 |
Plasmodium falciparum | transporter, putative | 0.0124 | 0.2968 | 1 |
Mycobacterium ulcerans | manganese transport protein MntH | 0.0124 | 0.2968 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.2968 | 0.2968 |
Onchocerca volvulus | Protein Malvolio homolog | 0.0124 | 0.2968 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0071 | 0.0685 | 0.0685 |
Plasmodium vivax | metal transporter, putative | 0.0124 | 0.2968 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0071 | 0.0685 | 0.0685 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0071 | 0.0685 | 0.0685 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0094 | 0.1702 | 0.5734 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.2968 | 0.2968 |
Mycobacterium leprae | DIVALENT CATION-TRANSPORT INTEGRAL MEMBRANE PROTEIN MNTH (BRAMP) (MRAMP) | 0.0076 | 0.0919 | 0.4455 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0071 | 0.0685 | 0.0685 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.1702 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0071 | 0.0685 | 0.0685 |
Schistosoma mansoni | divalent metal transporter DMT1B | 0.0124 | 0.2968 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1702 | 0.1702 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.1702 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0131 | 0.044 |
Brugia malayi | jmjC domain containing protein | 0.0071 | 0.0685 | 0.0685 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.1623 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 7.0795 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 141.2538 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.