Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Human immunodeficiency virus 1 | Aberrant vpr protein | Starlite/ChEMBL | No references |
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.0787 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0086 | 0.0045 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.0132 | 1 |
Giardia lamblia | Transglutaminase/protease, putative | 0.1233 | 0.371 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0326 | 0.0913 | 0.228 |
Brugia malayi | Muscleblind-like protein | 0.0167 | 0.0421 | 0.1134 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0421 | 0.5346 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0132 | 0.0173 |
Trichomonas vaginalis | peptide N-glycanase, putative | 0.1233 | 0.371 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0167 | 0.0421 | 0.0947 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0076 | 0.0019 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0059 | 0.0087 | 0.0028 |
Mycobacterium tuberculosis | Conserved protein | 0.1233 | 0.371 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.1233 | 0.371 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0326 | 0.0913 | 0.228 |
Echinococcus multilocularis | Transglutaminase | 0.1233 | 0.371 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0076 | 0.0206 |
Giardia lamblia | Hypothetical protein | 0.1233 | 0.371 | 1 |
Brugia malayi | Flap endonuclease-1 | 0.0059 | 0.0087 | 0.0234 |
Brugia malayi | Thioredoxin family protein | 0.1233 | 0.371 | 1 |
Schistosoma mansoni | hypothetical protein | 0.1233 | 0.371 | 1 |
Brugia malayi | hypothetical protein | 0.0286 | 0.0787 | 0.2121 |
Echinococcus granulosus | flap endonuclease 1 | 0.0059 | 0.0087 | 0.0028 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0132 | 0.0173 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0326 | 0.0913 | 0.228 |
Echinococcus granulosus | Transglutaminase | 0.1233 | 0.371 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.1233 | 0.371 | 1 |
Trypanosoma brucei | flap endonuclease-1 (FEN-1), putative | 0.0059 | 0.0087 | 1 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0059 | 0.0087 | 0.6561 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0326 | 0.0913 | 0.228 |
Mycobacterium ulcerans | transglutaminase family protein | 0.1233 | 0.371 | 1 |
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.1233 | 0.371 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0167 | 0.0421 | 0.0947 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0326 | 0.0913 | 0.5 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0059 | 0.0087 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.1233 | 0.371 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0167 | 0.0421 | 0.0947 |
Toxoplasma gondii | flap structure-specific endonuclease 1, putative | 0.0059 | 0.0087 | 0.6561 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0326 | 0.0913 | 0.228 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0159 | 0.0398 | 0.0742 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0326 | 0.0913 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0326 | 0.0913 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.0421 | 0.5346 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0059 | 0.0087 | 0.1103 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0076 | 0.0019 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.0132 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0326 | 0.0913 | 0.228 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.0132 | 0.0154 |
Mycobacterium ulcerans | hypothetical protein | 0.1233 | 0.371 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0326 | 0.0913 | 0.228 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0076 | 0.0972 |
Mycobacterium tuberculosis | Hypothetical protein | 0.1233 | 0.371 | 1 |
Plasmodium falciparum | flap endonuclease 1 | 0.0059 | 0.0087 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0159 | 0.0398 | 0.0742 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0086 | 0.0231 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0076 | 0.0019 |
Mycobacterium leprae | Conserved hypothetical protein | 0.1233 | 0.371 | 1 |
Mycobacterium tuberculosis | Long conserved protein | 0.1233 | 0.371 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0086 | 0.0045 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.0787 | 0.1955 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.0787 | 0.1955 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.1233 | 0.371 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0326 | 0.0913 | 0.228 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.0132 | 0.0154 |
Plasmodium vivax | flap endonuclease 1, putative | 0.0059 | 0.0087 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0326 | 0.0913 | 0.228 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 2.2387 um | PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.