TDR Targets

Basic information

Technical information

TDR Targets ID: 1406350
Name: furan-2-yl-[4-[(6-hydroxy-2-methyl-[1,3]thiaz olo[2,3-e][1,2,4]triazol-5-yl)-thiophen-2-ylm ethyl]piperazin-1-yl]methanone
MW: 429.516 | Formula: C19H19N5O3S2
H donors: 1 H acceptors: 4 LogP: 2.84 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Cc1nn2c(n1)sc(c2O)C(c1cccs1)N1CCN(CC1)C(=O)c1ccco1
InChi: 1S/C19H19N5O3S2/c1-12-20-19-24(21-12)18(26)16(29-19)15(14-5-3-11-28-14)22-6-8-23(9-7-22)17(25)13-4-2-10-27-13/h2-5,10-11,15,26H,6-9H2,1H3
InChiKey: HTOVIECVYFLKKU-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-furyl-[4-[(6-hydroxy-2-methyl-thiazolo[2,3-e][1,2,4]triazol-5-yl)-(2-thienyl)methyl]piperazin-1-yl]methanone
2-furyl-[4-[(6-hydroxy-2-methyl-5-thiazolo[2,3-e][1,2,4]triazolyl)-(2-thienyl)methyl]-1-piperazinyl]methanone
furan-2-yl-[4-[(6-hydroxy-2-methyl-[1,3]thiazolo[2,3-e][1,2,4]triazol-5-yl)-thiophen-2-yl-methyl]piperazin-1-yl]methanone
SMR000017273
MLS000101817

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	survival of motor neuron 2, centromeric	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Homo sapiens	thyroid stimulating hormone receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	follicle stimulating hormone receptor	Get druggable targets OG5_130089	All targets in OG5_130089
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Brugia malayi	follicle stimulating hormone receptor	Get druggable targets OG5_130089	All targets in OG5_130089
Brugia malayi	hypothetical protein	Get druggable targets OG5_132873	All targets in OG5_132873
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	survival motor neuron protein 1	Get druggable targets OG5_132873	All targets in OG5_132873

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	ankyrin 23/unc44	0.0016	0.0096	0.0216
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0013	0.0031	0.0031
Onchocerca volvulus		0.0058	0.1163	0.4084
Brugia malayi	hypothetical protein	0.0013	0.0031	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0031	0.0044
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0125	0.2848	0.5
Schistosoma mansoni	hypothetical protein	0.0013	0.0031	0.0068
Onchocerca volvulus		0.0013	0.0031	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0031	0.0044
Schistosoma mansoni	hypothetical protein	0.0189	0.4461	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0013	0.0031	0.0068
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0125	0.2848	1
Brugia malayi	Death domain containing protein	0.0016	0.0096	0.0139
Schistosoma mansoni	hypothetical protein	0.004	0.0704	0.1579
Echinococcus granulosus	netrin receptor unc 5	0.0016	0.0096	0.0096
Echinococcus granulosus	enteropeptidase	0.0013	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.006	0.12	0.1738
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0013	0.0031	0.0068
Echinococcus granulosus	glycoprotein Antigen 5	0.0013	0.0031	0.0031
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.004	0.0704	0.0704
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0096	0.0139
Echinococcus multilocularis	glycoprotein Antigen 5	0.0013	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0031	0.0044
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0125	0.2848	1
Loa Loa (eye worm)	hypothetical protein	0.0125	0.2848	0.4124
Brugia malayi	Trypsin family protein	0.0013	0.0031	0.0044
Leishmania major	eukaryotic initiation factor 4a, putative	0.0125	0.2848	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0013	0.0031	0.0068
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0018	0.0136	0.0136
Schistosoma mansoni	hypothetical protein	0.0189	0.4461	1
Echinococcus multilocularis	transmembrane protease serine 3	0.0013	0.0031	0.0031
Onchocerca volvulus		0.0013	0.0031	0.0107
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0016	0.0096	0.0096
Echinococcus granulosus	Ankyrin	0.0016	0.01	0.01
Brugia malayi	hypothetical protein	0.004	0.0704	0.102
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0125	0.2848	1
Loa Loa (eye worm)	trypsin family protein	0.0013	0.0031	0.0044
Schistosoma mansoni	cercarial elastase (S01 family)	0.0013	0.0031	0.0068
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0125	0.2848	0.6384
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1087	0.2437
Schistosoma mansoni	cercarial elastase (S01 family)	0.0013	0.0031	0.0068
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.12	0.2691
Onchocerca volvulus		0.0013	0.0031	0.0107
Schistosoma mansoni	cercarial elastase (S01 family)	0.0013	0.0031	0.0068
Onchocerca volvulus		0.0013	0.0031	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0016	0.01	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0031	0.0044
Schistosoma mansoni	cercarial elastase (S01 family)	0.0013	0.0031	0.0068
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0096	0.0139
Schistosoma mansoni	cercarial elastase (S01 family)	0.0013	0.0031	0.0068
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.1163	0.1684
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0016	0.0096	0.0139
Onchocerca volvulus		0.0013	0.0031	0.0107
Schistosoma mansoni	netrin receptor unc5	0.0016	0.0096	0.0216
Brugia malayi	Trypsin family protein	0.0013	0.0031	0.0044
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1087	0.2437
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0246	0.591	0.591
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0013	0.0031	0.0044
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0013	0.0031	0.0068
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0125	0.2848	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.1087	0.2437
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.004	0.0704	0.0704
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0016	0.0096	0.0139
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0031	0.0044
Brugia malayi	Trypsin-like protease protein 5	0.0013	0.0031	0.0044
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0016	0.01	0.0224
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0125	0.2848	0.2848
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0013	0.0031	0.0068
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.028	0.6758	0.9785
Schistosoma mansoni	cercarial elastase (S01 family)	0.0013	0.0031	0.0068
Schistosoma mansoni	cercarial elastase (S01 family)	0.0013	0.0031	0.0068
Schistosoma mansoni	transcription factor LCR-F1	0.004	0.0704	0.1579
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0018	0.0136	0.0197
Brugia malayi	isocitrate dehydrogenase	0.0018	0.0136	0.0197
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0018	0.0136	0.0306
Schistosoma mansoni	cercarial elastase (S01 family)	0.0013	0.0031	0.0068
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0125	0.2848	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1087	0.1087
Brugia malayi	Uncoordinated protein 44	0.0016	0.0096	0.0139
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.1087	0.1087
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0125	0.2848	0.6384
Brugia malayi	Isocitrate dehydrogenase	0.0018	0.0136	0.0197
Schistosoma mansoni	survival motor neuron protein	0.0058	0.1163	0.2607
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0125	0.2848	0.2848
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0125	0.2848	0.2848
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0136	0.0136
Onchocerca volvulus		0.006	0.12	0.4215
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.6906	0.6906
Echinococcus multilocularis	isocitrate dehydrogenase	0.0018	0.0136	0.0136
Onchocerca volvulus	Netrin receptor homolog	0.0016	0.0096	0.0338
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0125	0.2848	0.2848
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0013	0.0031	0.0031
Echinococcus granulosus	transmembrane protease serine 3	0.0013	0.0031	0.0031
Echinococcus multilocularis	Ankyrin	0.0016	0.01	0.01
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0013	0.0031	0.0031
Schistosoma mansoni	hypothetical protein	0.0058	0.1163	0.2607
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0031	0.0044
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0013	0.0031	0.0068
Echinococcus multilocularis	netrin receptor unc 5	0.0016	0.0096	0.0096
Echinococcus granulosus	death domain containing protein	0.0016	0.0096	0.0096
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0125	0.2848	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0013	0.0031	0.0068
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0013	0.0031	0.0031
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0013	0.0031	0.0068
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0136	0.0136
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.6906	0.6906
Loa Loa (eye worm)	hypothetical protein	0.0286	0.6906	1
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0246	0.591	0.591
Plasmodium vivax	RNA helicase-1, putative	0.0125	0.2848	1
Echinococcus multilocularis	geminin	0.0189	0.4461	0.4461
Brugia malayi	Trypsin family protein	0.0013	0.0031	0.0044
Schistosoma mansoni	cercarial elastase (S01 family)	0.0013	0.0031	0.0068
Schistosoma mansoni	hypothetical protein	0.0013	0.0031	0.0068
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0018	0.0136	0.0136
Echinococcus multilocularis	Mastin	0.0013	0.0031	0.0031
Mycobacterium ulcerans	hypothetical protein	0.0013	0.0031	0.5
Brugia malayi	follicle stimulating hormone receptor	0.028	0.6758	0.9785
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0125	0.2848	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.1087	0.1574
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1087	0.1087
Brugia malayi	Trypsin family protein	0.0013	0.0031	0.0044
Brugia malayi	eukaryotic initiation factor 4A	0.0125	0.2848	0.4124
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0125	0.2848	0.5
Brugia malayi	hypothetical protein	0.0286	0.6906	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0096	0.0216
Leishmania major	eukaryotic initiation factor 4a, putative	0.0125	0.2848	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0018	0.0136	0.0136
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0031	0.0044
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.1087	0.1087
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0016	0.0096	0.0096
Treponema pallidum	ATP-dependent RNA helicase	0.0125	0.2848	0.5
Onchocerca volvulus		0.0013	0.0031	0.0107
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0125	0.2848	0.5
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0125	0.2848	1
Echinococcus granulosus	geminin	0.0189	0.4461	0.4461
Echinococcus granulosus	Mastin	0.0013	0.0031	0.0031
Echinococcus multilocularis	enteropeptidase	0.0013	0.0031	0.0031
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0125	0.2848	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.1087	0.1574
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0013	0.0031	0.0068
Schistosoma mansoni	cercarial elastase (S01 family)	0.0013	0.0031	0.0068

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.631 um	PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.7943 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 6.3096 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 8.9125 um	PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 8.9125 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 10 um	PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	16.5113 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 28.1838 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	28.1838 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 31.6228 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	31.6228 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	112.2018 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1562710

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1406350