Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2644 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2644 | 0.0241 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2644 | 0.0241 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.2462 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2644 | 0.0241 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2644 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2644 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2644 | 0.0241 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.2462 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.2462 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.2462 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2644 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.2462 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2644 | 0.0241 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.2462 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2644 | 0.0241 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2644 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2644 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2644 | 0.0241 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.8356 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 1.9953 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 26.8545 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.