Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | Rap guanine nucleotide exchange factor (GEF) 4 | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0146 | 0.0146 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0011 | 0.0146 | 0.0447 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0146 | 0.0146 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3273 | 0.3273 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0146 | 0.0447 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0011 | 0.0146 | 0.0146 |
Toxoplasma gondii | exonuclease III APE | 0.0023 | 0.0716 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.0716 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0146 | 0.0146 |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0011 | 0.0146 | 0.0146 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0146 | 0.0447 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0146 | 0.0447 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0716 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3273 | 1 |
Onchocerca volvulus | 0.0011 | 0.0146 | 0.0146 | |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0716 | 0.2188 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3273 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0716 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0716 | 0.5 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0146 | 0.0447 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0146 | 0.0447 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3273 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0716 | 0.5 |
Schistosoma mansoni | dep domain containing protein | 0.0011 | 0.0146 | 0.0447 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0716 | 0.5 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0023 | 0.0716 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3273 | 0.3273 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0146 | 0.0447 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0146 | 0.0447 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3273 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0716 | 0.0716 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0011 | 0.0146 | 0.0447 |
Brugia malayi | DIX domain containing protein | 0.0011 | 0.0146 | 0.0146 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0146 | 0.0447 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0011 | 0.0146 | 0.0447 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3273 | 0.3273 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0011 | 0.0146 | 0.0146 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0716 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0716 | 0.2188 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0011 | 0.0146 | 0.0146 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.0716 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0716 | 1 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0146 | 0.0146 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0023 | 0.0716 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3273 | 0.3273 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3273 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0716 | 0.2188 |
Schistosoma mansoni | regulator of G protein signaling | 0.0011 | 0.0146 | 0.0447 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3273 | 0.3273 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0146 | 0.0146 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0146 | 0.0447 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0716 | 0.0716 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0146 | 0.0447 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0218 | 1 | 1 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0011 | 0.0146 | 0.0447 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0716 | 0.2188 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0023 | 0.0716 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3273 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0716 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3273 | 1 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0146 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0146 | 0.0146 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0716 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3273 | 0.3273 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0032 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.0787 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 23.3228 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 56.2341 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Saccharomyces cerevisiae | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.