Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0277 | 0.9963 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0277 | 0.9963 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0277 | 0.9963 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0277 | 0.9963 | 1 |
Brugia malayi | TAR-binding protein | 0.0277 | 0.9963 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.4298 | 0.4313 |
Schistosoma mansoni | tar DNA-binding protein | 0.0277 | 0.9963 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0 | 0.5 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0277 | 0.9963 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.4298 | 0.4313 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0277 | 0.9963 | 1 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0277 | 0.9963 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0277 | 0.9963 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0277 | 0.9963 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.4298 | 0.4313 |
Onchocerca volvulus | 0.0043 | 0 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0277 | 0.9963 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0277 | 0.9963 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.5623 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.