Detailed information for compound 1423145

Basic information

Technical information
  • TDR Targets ID: 1423145
  • Name: N-(3,4-dimethylphenyl)-4-[[5-(4-methoxyphenyl )-4-methyl-1,1,3-trioxo-1,2-thiazol-2-yl]meth yl]benzamide
  • MW: 490.571 | Formula: C27H26N2O5S
  • H donors: 1 H acceptors: 4 LogP: 4.21 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C1=C(C)C(=O)N(S1(=O)=O)Cc1ccc(cc1)C(=O)Nc1ccc(c(c1)C)C
  • InChi: 1S/C27H26N2O5S/c1-17-5-12-23(15-18(17)2)28-26(30)22-8-6-20(7-9-22)16-29-27(31)19(3)25(35(29,32)33)21-10-13-24(34-4)14-11-21/h5-15H,16H2,1-4H3,(H,28,30)
  • InChiKey: WAYAZGZCTNYMGP-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

  • N-(3,4-dimethylphenyl)-4-[[5-(4-methoxyphenyl)-4-methyl-1,1,3-trioxo-isothiazol-2-yl]methyl]benzamide
  • N-(3,4-dimethylphenyl)-4-[[5-(4-methoxyphenyl)-4-methyl-1,1,3-trioxo-2-isothiazolyl]methyl]benzamide
  • N-(3,4-dimethylphenyl)-4-[[1,1,3-triketo-5-(4-methoxyphenyl)-4-methyl-isothiazol-2-yl]methyl]benzamide
  • G206-2545
  • NCGC00129082-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0286 0.232 0.4286
Brugia malayi isocitrate dehydrogenase 0.0079 0.0392 0.0375
Schistosoma mansoni hypothetical protein 0.0045 0.007 0.013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0286 0.232 0.7136
Brugia malayi RNA recognition motif domain containing protein 0.0385 0.3244 0.3232
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0286 0.232 0.7136
Entamoeba histolytica hypothetical protein 0.0043 0.006 1
Echinococcus multilocularis GPCR, family 2 0.0286 0.232 0.7136
Loa Loa (eye worm) hypothetical protein 0.0099 0.0581 0.0564
Echinococcus granulosus segment polarity protein dishevelled 0.0055 0.0164 0.0453
Toxoplasma gondii isocitrate dehydrogenase 0.0079 0.0392 0.547
Schistosoma mansoni tar DNA-binding protein 0.0385 0.3244 0.5993
Toxoplasma gondii LsmAD domain-containing protein 0.0099 0.0581 1
Echinococcus granulosus regulator of G protein signaling 7 0.0055 0.0164 0.0453
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0055 0.0164 0.0146
Echinococcus granulosus GPCR family 2 0.0286 0.232 0.7136
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0373 0.631
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0079 0.0392 0.116
Entamoeba histolytica hypothetical protein 0.0043 0.006 1
Echinococcus granulosus segment polarity protein dishevelled 0.0055 0.0164 0.0453
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0903 0.8077 0.8074
Brugia malayi hypothetical protein 0.0099 0.0581 0.0564
Entamoeba histolytica hypothetical protein 0.0043 0.006 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.111 1 1
Echinococcus granulosus regulator of G protein signaling 7 0.0055 0.0164 0.0453
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0045 0.007 0.0162
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0079 0.0392 0.116
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0311 0.5203
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0392 0.091
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0055 0.0164 0.0146
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0079 0.0392 0.5
Schistosoma mansoni tar DNA-binding protein 0.0385 0.3244 0.5993
Brugia malayi hypothetical protein 0.0064 0.0253 0.0235
Trypanosoma cruzi PAB1-binding protein , putative 0.0099 0.0581 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0286 0.232 0.7136
Brugia malayi DIX domain containing protein 0.0055 0.0164 0.0146
Schistosoma mansoni regulator of G protein signaling 0.0055 0.0164 0.0303
Schistosoma mansoni dep domain containing protein 0.0055 0.0164 0.0303
Schistosoma mansoni tar DNA-binding protein 0.0385 0.3244 0.5993
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0055 0.0164 0.0146
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0373 0.631
Loa Loa (eye worm) TAR-binding protein 0.0385 0.3244 0.3232
Loa Loa (eye worm) hypothetical protein 0.0055 0.0164 0.0146
Loa Loa (eye worm) glutaminase 2 0.0317 0.2609 0.2596
Brugia malayi hypothetical protein 0.0055 0.0164 0.0146
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0392 0.116
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0039 0.0018 0.0033
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0385 0.3244 0.3232
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0392 0.116
Brugia malayi regulator of G-protein signaling egl-10 0.0055 0.0164 0.0146
Brugia malayi hypothetical protein 0.0055 0.0164 0.0146
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0079 0.0392 0.091
Loa Loa (eye worm) hypothetical protein 0.0617 0.5412 0.5404
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0079 0.0392 0.0724
Schistosoma mansoni hypothetical protein 0.0286 0.232 0.4286
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0039 0.0018 0.0033
Plasmodium falciparum ataxin-2 like protein, putative 0.0099 0.0581 1
Toxoplasma gondii isocitrate dehydrogenase 0.0079 0.0392 0.547
Brugia malayi RNA binding protein 0.0385 0.3244 0.3232
Echinococcus multilocularis tar DNA binding protein 0.0385 0.3244 1
Entamoeba histolytica hypothetical protein 0.0043 0.006 1
Trichomonas vaginalis glutaminase, putative 0.0317 0.2609 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0903 0.8077 0.8074
Schistosoma mansoni glutaminase 0.0317 0.2609 0.482
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.006 0.0131
Brugia malayi hypothetical protein 0.0043 0.006 0.0042
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0079 0.0392 0.6645
Brugia malayi MH2 domain containing protein 0.0144 0.0999 0.0983
Schistosoma mansoni dishevelled 0.0055 0.0164 0.0303
Trypanosoma cruzi PAB1-binding protein , putative 0.0099 0.0581 1
Brugia malayi Latrophilin receptor protein 2 0.0286 0.232 0.2306
Echinococcus multilocularis regulator of G protein signaling 7 0.0055 0.0164 0.0453
Schistosoma mansoni hypothetical protein 0.0617 0.5412 1
Trypanosoma brucei PAB1-binding protein , putative 0.0099 0.0581 1
Brugia malayi TAR-binding protein 0.0385 0.3244 0.3232
Brugia malayi latrophilin 2 splice variant baaae 0.0617 0.5412 0.5404
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0055 0.0164 0.0146
Brugia malayi glutaminase DH11.1 0.0317 0.2609 0.2596
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0999 0.0983
Loa Loa (eye worm) isocitrate dehydrogenase 0.0079 0.0392 0.0375
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.0373 0.631
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0392 0.6645
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0079 0.0392 0.091
Schistosoma mansoni z-protein (S1r protein) 0.0055 0.0164 0.0303
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0039 0.0018 0.0033
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0286 0.232 0.7136
Echinococcus granulosus Pleckstrin G protein interacting region 0.0055 0.0164 0.0453
Loa Loa (eye worm) DIX domain-containing protein 0.0055 0.0164 0.0146
Schistosoma mansoni tar DNA-binding protein 0.0385 0.3244 0.5993
Schistosoma mansoni ras GTP exchange factor 0.0039 0.0018 0.0033
Onchocerca volvulus 0.0055 0.0164 0.0146
Echinococcus multilocularis isocitrate dehydrogenase 0.0079 0.0392 0.116
Schistosoma mansoni dishevelled 0.0055 0.0164 0.0303
Schistosoma mansoni hypothetical protein 0.0286 0.232 0.4286
Echinococcus granulosus tar DNA binding protein 0.0385 0.3244 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.0219 0.358
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0055 0.0164 0.0453
Leishmania major hypothetical protein, conserved 0.0099 0.0581 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0099 0.0581 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0999 0.0983
Schistosoma mansoni tar DNA-binding protein 0.0385 0.3244 0.5993
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0039 0.0018 0.0033
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0903 0.8077 0.8074
Schistosoma mansoni hypothetical protein 0.0286 0.232 0.4286
Loa Loa (eye worm) hypothetical protein 0.0055 0.0164 0.0146
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.006 0.0131
Brugia malayi Isocitrate dehydrogenase 0.0079 0.0392 0.0375
Loa Loa (eye worm) glutaminase 0.0317 0.2609 0.2596
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0286 0.232 0.2306
Loa Loa (eye worm) hypothetical protein 0.0903 0.8077 0.8074
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0079 0.0392 0.116
Loa Loa (eye worm) hypothetical protein 0.0286 0.232 0.2306
Loa Loa (eye worm) hypothetical protein 0.111 1 1
Loa Loa (eye worm) RNA binding protein 0.0385 0.3244 0.3232
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.0373 0.631
Mycobacterium ulcerans glutaminase 0.0317 0.2609 0.5
Plasmodium vivax ataxin-2 like protein, putative 0.0099 0.0581 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0286 0.232 0.2306
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0045 0.007 0.0162
Loa Loa (eye worm) hypothetical protein 0.0055 0.0164 0.0146
Echinococcus multilocularis regulator of G protein signaling 7 0.0055 0.0164 0.0453
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0055 0.0164 0.0303
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.006 0.0111
Schistosoma mansoni hypothetical protein 0.0043 0.006 0.0111
Echinococcus multilocularis segment polarity protein dishevelled 0.0055 0.0164 0.0453
Echinococcus multilocularis segment polarity protein dishevelled 0.0055 0.0164 0.0453

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1158 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 112.2018 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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