TDR Targets

Basic information

Technical information

TDR Targets ID: 1426092
Name: 3'-[2-(4-ethoxyphenoxy)ethyl]spiro[2,3-dihydr o-1H-naphthalene-4,5'-imidazolidine]-2',4'-di one
MW: 380.437 | Formula: C22H24N2O4
H donors: 1 H acceptors: 2 LogP: 3.41 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)OCCN1C(=O)NC2(C1=O)CCCc1c2cccc1
InChi: 1S/C22H24N2O4/c1-2-27-17-9-11-18(12-10-17)28-15-14-24-20(25)22(23-21(24)26)13-5-7-16-6-3-4-8-19(16)22/h3-4,6,8-12H,2,5,7,13-15H2,1H3,(H,23,26)
InChiKey: DDTBBIRKKQJGCM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[2-(4-ethoxyphenoxy)ethyl]spiro[imidazolidine-5,1'-tetralin]-2,4-dione
3-[2-(4-ethoxyphenoxy)ethyl]spiro[imidazolidine-5,1'-tetralin]-2,4-quinone
MLS000058103
SMR000067534
T5269797

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	muscleblind-like splicing regulator 1	Starlite/ChEMBL	No references
Influenza A virus	Nonstructural protein 1	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	muscleblind protein 1	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	Muscleblind-like protein	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus multilocularis	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Mycobacterium tuberculosis	Hypothetical protein	Nonstructural protein 1	230 aa	202 aa	23.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	protein kinase	0.0051	0.0517	0.1553
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0466	0.1735
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0254	0.0945
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0165	0.2188	0.8138
Loa Loa (eye worm)	hypothetical protein	0.005	0.0502	0.187
Trypanosoma brucei	glucose transporter, putative	0.0051	0.0527	0.8107
Echinococcus multilocularis	solute carrier family 22	0.0023	0.0119	0.041
Echinococcus granulosus	solute carrier family 22	0.0023	0.0119	0.041
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.005	0.0502	0.1766
Echinococcus multilocularis	solute carrier family 22	0.0023	0.0119	0.041
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0034	0.0126
Loa Loa (eye worm)	hypothetical protein	0.018	0.2405	0.8951
Schistosoma mansoni	hypothetical protein	0.0074	0.0855	0.2866
Leishmania major	glucose transporter, lmgt1	0.0051	0.0527	0.8107
Brugia malayi	TAR-binding protein	0.02	0.2687	1
Brugia malayi	hypothetical protein	0.0023	0.0119	0.0319
Trichomonas vaginalis	conserved hypothetical protein	0.0165	0.2188	1
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0023	0.0119	0.2954
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0267	0.3671	0.5495
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0058	0.0622	0.0779
Mycobacterium ulcerans	integral membrane transport protein	0.0023	0.0119	0.2954
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0051	0.0517	0.1899
Loa Loa (eye worm)	hypothetical protein	0.0149	0.1949	0.7253
Brugia malayi	RNA recognition motif domain containing protein	0.02	0.2687	1
Plasmodium falciparum	protein kinase 7	0.0468	0.6583	0.6542
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0149	0.1949	0.7253
Schistosoma mansoni	hypothetical protein	0.0102	0.1262	0.4454
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0254	0.0945
Loa Loa (eye worm)	hypothetical protein	0.004	0.0367	0.1366
Schistosoma mansoni	hypothetical protein	0.0047	0.0466	0.1353
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0165	0.2188	0.8138
Loa Loa (eye worm)	RNA binding protein	0.02	0.2687	1
Echinococcus multilocularis	muscleblind protein 1	0.018	0.2405	0.8948
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0254	0.0829
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.02	0.2687	1
Schistosoma mansoni	glucose transport protein	0.0165	0.2188	0.8058
Plasmodium falciparum	proline--tRNA ligase	0.0058	0.0622	0.051
Schistosoma mansoni	glucose transport protein	0.0165	0.2188	0.8058
Echinococcus multilocularis	musashi	0.0033	0.0254	0.0916
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0051	0.0517	0.1899
Loa Loa (eye worm)	sugar transporter	0.0165	0.2188	0.8144
Schistosoma mansoni	hypothetical protein	0.0047	0.0466	0.1353
Brugia malayi	major facilitator superfamily protein	0.0023	0.0119	0.0319
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0023	0.0119	0.5
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.002	0.0077	0.0285
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0119	0.0441
Loa Loa (eye worm)	hypothetical protein	0.005	0.0502	0.187
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0047	0.0466	0.1708
Echinococcus granulosus	intermediate filament protein	0.0033	0.0254	0.0916
Trypanosoma cruzi	hexose transporter, putative	0.0051	0.0527	0.8107
Toxoplasma gondii	protein kinase, putative	0.0468	0.6583	1
Plasmodium vivax	proline--tRNA ligase, putative	0.0058	0.0622	0.051
Brugia malayi	RNA binding protein	0.02	0.2687	1
Trypanosoma brucei	glucose transporter, putative	0.0051	0.0527	0.8107
Schistosoma mansoni	protein kinase	0.0051	0.0517	0.1553
Entamoeba histolytica	hypothetical protein	0.0074	0.0855	1
Trichomonas vaginalis	CAMK family protein kinase	0.0051	0.0517	0.1927
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0047	0.0466	0.1629
Schistosoma mansoni	tar DNA-binding protein	0.02	0.2687	1
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.005	0.0502	0.1855
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0317	0.1182
Trypanosoma brucei	glucose transporter, putative	0.0051	0.0527	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0119	0.0441
Echinococcus multilocularis	lamin	0.0033	0.0254	0.0916
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0058	0.0622	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0051	0.0518	0.0617
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.005	0.0502	0.1844
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0051	0.0518	0.0404
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0051	0.0527	0.8107
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0051	0.0517	0.1899
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0037	0.0317	0.395
Brugia malayi	lysyl-tRNA synthetase	0.0037	0.0317	0.1069
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0023	0.0119	0.0441
Echinococcus multilocularis	tar DNA binding protein	0.02	0.2687	1
Brugia malayi	Muscleblind-like protein	0.018	0.2405	0.8938
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0267	0.3671	0.3595
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0023	0.0119	0.041
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0165	0.2188	0.8138
Loa Loa (eye worm)	MH2 domain-containing protein	0.0117	0.1479	0.5505
Trypanosoma brucei	glucose transporter, putative	0.0051	0.0527	0.8107
Leishmania major	glucose transporter, lmgt3	0.0051	0.0527	0.8107
Echinococcus granulosus	General substrate transporter	0.0142	0.1849	0.6873
Echinococcus multilocularis	GPCR, family 2	0.0047	0.0466	0.1708
Schistosoma mansoni	tar DNA-binding protein	0.02	0.2687	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0149	0.1949	0.7217
Schistosoma mansoni	tar DNA-binding protein	0.02	0.2687	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0051	0.0517	0.1899
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0047	0.0466	0.1708
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0119	0.0441
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0037	0.0317	0.395
Brugia malayi	Major Facilitator Superfamily protein	0.0023	0.0119	0.0319
Trypanosoma brucei	glucose transporter, putative	0.0051	0.0527	0.8107
Trypanosoma brucei	glucose transporter 1E	0.0051	0.0527	0.8107
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0051	0.0517	0.1925
Trypanosoma brucei	glucose transporter, putative	0.0051	0.0527	0.8107
Leishmania major	protein kinase, putative	0.0051	0.0517	0.7919
Toxoplasma gondii	facilitative glucose transporter GT1	0.0165	0.2188	0.3201
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0051	0.0518	0.0404
Entamoeba histolytica	hypothetical protein	0.0074	0.0855	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0074	0.0855	0.3158
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0051	0.0518	0.0404
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0165	0.2188	0.8138
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0051	0.0517	0.1925
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0527	0.1973
Schistosoma mansoni	glucose transport protein	0.0165	0.2188	0.8058
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0051	0.0518	0.0404
Echinococcus granulosus	muscleblind protein	0.018	0.2405	0.8948
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0119	0.0441
Echinococcus multilocularis	lysyl tRNA synthetase	0.0037	0.0317	0.1153
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0058	0.0622	1
Trichomonas vaginalis	sugar transporter, putative	0.0051	0.0527	0.1973
Entamoeba histolytica	protein kinase, putative	0.0051	0.0517	0.3721
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0047	0.0466	0.1708
Trichomonas vaginalis	conserved hypothetical protein	0.0051	0.0527	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0119	0.0441
Schistosoma mansoni	hypothetical protein	0.0165	0.2188	0.8058
Giardia lamblia	Prolyl-tRNA synthetase	0.005	0.0502	1
Onchocerca volvulus		0.0033	0.0254	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0165	0.2188	0.8138
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0119	0.0441
Brugia malayi	Sugar transporter family protein	0.0023	0.0119	0.0319
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0023	0.0119	0.2954
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0165	0.2188	0.8138
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0702	1	1
Leishmania major	glucose transporter, lmgt2	0.0051	0.0527	0.8107
Giardia lamblia	Lysyl-tRNA synthetase	0.0037	0.0317	0.5182
Entamoeba histolytica	hypothetical protein	0.0074	0.0855	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0245	0.0913
Echinococcus granulosus	synaptic vesicle 2 protein	0.0023	0.0119	0.041
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0058	0.0622	1
Loa Loa (eye worm)	TAR-binding protein	0.02	0.2687	1
Loa Loa (eye worm)	sugar transporter	0.0023	0.0119	0.0441
Treponema pallidum	prolyl-tRNA synthetase	0.0018	0.0035	0.5
Brugia malayi	hypothetical protein	0.0074	0.0855	0.3094
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0031	0.0236	1
Onchocerca volvulus		0.0033	0.0254	1
Echinococcus multilocularis	muscleblind protein	0.018	0.2405	0.8948
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0023	0.0119	0.041
Trypanosoma cruzi	hexose transporter, putative	0.0051	0.0527	0.8107
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0165	0.2188	0.8138
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0119	0.0441
Echinococcus granulosus	solute carrier family 22	0.0023	0.0119	0.041
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0119	0.0441
Echinococcus multilocularis	solute carrier family 22	0.0023	0.0119	0.041
Echinococcus granulosus	tar DNA binding protein	0.02	0.2687	1
Plasmodium vivax	hexose transporter	0.0165	0.2188	0.2094
Brugia malayi	Sugar transporter family protein	0.0023	0.0119	0.0319
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0051	0.0518	0.0404
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0051	0.0517	0.7919
Schistosoma mansoni	protein kinase	0.0051	0.0517	0.1553
Trypanosoma cruzi	hexose transporter	0.0051	0.0527	0.8107
Schistosoma mansoni	hypothetical protein	0.0047	0.0466	0.1353
Brugia malayi	Latrophilin receptor protein 2	0.0047	0.0466	0.1629
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0051	0.0518	0.0404
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0037	0.0317	0.3046
Trypanosoma cruzi	hexose transporter, putative	0.0028	0.0188	0.1383
Brugia malayi	latrophilin 2 splice variant baaae	0.0102	0.1262	0.4631
Echinococcus granulosus	solute carrier family 22	0.0023	0.0119	0.041
Brugia malayi	major facilitator superfamily protein	0.0023	0.0119	0.0319
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0074	0.0855	0.3158
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0119	0.0441
Echinococcus granulosus	lysyl tRNA synthetase	0.0037	0.0317	0.1153
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.005	0.0502	0.1844
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0267	0.3671	0.3595
Brugia malayi	Major Facilitator Superfamily protein	0.0023	0.0119	0.0319
Mycobacterium ulcerans	sugar transporter	0.0023	0.0119	0.2954
Trypanosoma brucei	glucose transporter, putative	0.0051	0.0527	0.8107
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0165	0.2188	0.8138
Entamoeba histolytica	protein kinase, putative	0.0051	0.0517	0.3721
Entamoeba histolytica	hypothetical protein	0.0074	0.0855	1
Loa Loa (eye worm)	hypothetical protein	0.018	0.2405	0.8951
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0119	0.0441
Brugia malayi	MH2 domain containing protein	0.0117	0.1479	0.5447
Plasmodium falciparum	lysine--tRNA ligase	0.0037	0.0317	0.0201
Echinococcus granulosus	lamin dm0	0.0033	0.0254	0.0916
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0051	0.0517	0.1899
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1262	0.4699
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0051	0.0518	0.0617
Echinococcus multilocularis	solute carrier family 22	0.0023	0.0119	0.041
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0119	0.0441
Leishmania major	lysyl-tRNA synthetase, putative	0.0037	0.0317	0.395
Schistosoma mansoni	lysyl-tRNA synthetase	0.0037	0.0317	0.0774
Plasmodium vivax	lysine--tRNA ligase, putative	0.0037	0.0317	0.0201
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0051	0.0527	0.8107
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0023	0.0119	0.041
Schistosoma mansoni	hypothetical protein	0.0047	0.0466	0.1353
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.005	0.0502	0.1495
Schistosoma mansoni	tar DNA-binding protein	0.02	0.2687	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0517	0.1925
Toxoplasma gondii	lysine-tRNA ligase	0.0037	0.0317	0.0308
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0051	0.0518	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0119	0.0441
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0051	0.0517	0.1899
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0051	0.0517	0.1822
Chlamydia trachomatis	lysine--tRNA ligase	0.0037	0.0317	1
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.005	0.0502	0.1495
Brugia malayi	Cam kinase protein 1	0.0051	0.0517	0.1822
Trichomonas vaginalis	glucose transporter, putative	0.0051	0.0527	0.1973
Trichomonas vaginalis	sugar transporter, putative	0.0051	0.0527	0.1973
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.005	0.0502	1
Brugia malayi	Sugar transporter family protein	0.0165	0.2188	0.812
Brugia malayi	hypothetical protein	0.0023	0.0119	0.0319
Brugia malayi	intermediate filament protein	0.0033	0.0254	0.0829
Trichomonas vaginalis	sugar transporter, putative	0.0051	0.0527	0.1973
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0254	0.0945
Schistosoma mansoni	lysyl-tRNA synthetase	0.0037	0.0317	0.0774
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0009	0.0032
Trypanosoma brucei	glucose transporter, putative	0.0051	0.0527	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0119	0.0441
Brugia malayi	hypothetical protein	0.0023	0.0119	0.0319
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0051	0.0527	0.8107
Plasmodium falciparum	hexose transporter	0.0165	0.2188	0.2094
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.005	0.0502	0.3444
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.0517	0.1553
Trypanosoma cruzi	hexose transporter, putative	0.0051	0.0527	0.8107
Schistosoma mansoni	transcription factor LCR-F1	0.0074	0.0855	0.2866
Echinococcus granulosus	lamin	0.0033	0.0254	0.0916
Echinococcus multilocularis	calcium dependent protein kinase	0.0048	0.0472	0.1729
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0023	0.0119	0.0441
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0032	0.0251	0.0641
Schistosoma mansoni	lamin	0.0033	0.0254	0.0527
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0051	0.0517	0.1899
Echinococcus multilocularis	General substrate transporter	0.0142	0.1849	0.6873
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0037	0.0317	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0117	0.1479	0.5505
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0058	0.0622	1
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.005	0.0502	0.1766
Echinococcus granulosus	GPCR family 2	0.0047	0.0466	0.1708
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0119	0.0441
Schistosoma mansoni	lamin	0.0033	0.0254	0.0527
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0149	0.1949	0.7217
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0051	0.0527	0.8107
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0037	0.0317	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0047	0.0466	0.1735
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0119	0.0441
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0051	0.0518	0.0404
Trypanosoma brucei	glucose transporter 2A	0.0051	0.0527	0.8107
Schistosoma mansoni	tar DNA-binding protein	0.02	0.2687	1
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0051	0.0517	0.1899
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0051	0.0518	0.0404
Trichomonas vaginalis	glucose transporter, putative	0.0051	0.0527	0.1973
Echinococcus multilocularis	lamin dm0	0.0033	0.0254	0.0916
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0037	0.0317	0.0961
Brugia malayi	Major Facilitator Superfamily protein	0.0023	0.0119	0.0319
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0051	0.0518	0.0617
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0254	0.0527
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0031	0.0236	1
Echinococcus granulosus	calcium dependent protein kinase	0.0048	0.0472	0.1729
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0058	0.0622	1
Echinococcus granulosus	solute carrier family 22	0.0023	0.0119	0.041
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0047	0.0466	0.1708

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (binding)	0.631 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 11.2202 um	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1559729

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1426092