Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | integrin alpha 3 | 0.1177 | 0.4408 | 1 |
Schistosoma mansoni | integrin alpha | 0.1536 | 0.6093 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.1165 | 0.4351 | 0.9857 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 0.0428 | 0.0428 |
Brugia malayi | Integrin beta pat-3 precursor | 0.1573 | 0.6267 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.0358 | 0.0561 | 0.0236 |
Echinococcus multilocularis | integrin alpha ps | 0.0688 | 0.2112 | 0.4231 |
Loa Loa (eye worm) | hypothetical protein | 0.0847 | 0.2858 | 0.2858 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.1162 | 0.4335 | 0.6918 |
Echinococcus granulosus | integrin beta 2 | 0.1165 | 0.4351 | 0.9857 |
Echinococcus multilocularis | integrin alpha ps | 0.0688 | 0.2112 | 0.4231 |
Loa Loa (eye worm) | hypothetical protein | 0.0358 | 0.0561 | 0.0561 |
Schistosoma mansoni | integrin alpha-ps | 0.0688 | 0.2112 | 0.2973 |
Loa Loa (eye worm) | hypothetical protein | 0.1162 | 0.4335 | 0.4335 |
Echinococcus granulosus | integrin alpha 3 | 0.1177 | 0.4408 | 1 |
Echinococcus granulosus | integrin alpha ps | 0.0688 | 0.2112 | 0.4231 |
Loa Loa (eye worm) | hypothetical protein | 0.1206 | 0.4542 | 0.4542 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.1536 | 0.6093 | 0.9722 |
Loa Loa (eye worm) | integrin beta-2 | 0.1573 | 0.6267 | 0.6267 |
Schistosoma mansoni | integrin beta subunit | 0.0926 | 0.3229 | 0.4944 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5171 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.