Detailed information for compound 1433005

Basic information

Technical information
  • TDR Targets ID: 1433005
  • Name: 2-[4-(4-chlorophenoxy)-3-nitrophenyl]-5-pheny l-1,3,4-oxadiazole
  • MW: 393.78 | Formula: C20H12ClN3O4
  • H donors: 0 H acceptors: 4 LogP: 5.06 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)Oc1ccc(cc1[N+](=O)[O-])c1nnc(o1)c1ccccc1
  • InChi: 1S/C20H12ClN3O4/c21-15-7-9-16(10-8-15)27-18-11-6-14(12-17(18)24(25)26)20-23-22-19(28-20)13-4-2-1-3-5-13/h1-12H
  • InChiKey: TZUGFRRNDRTXFR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[4-(4-chlorophenoxy)-3-nitro-phenyl]-5-phenyl-1,3,4-oxadiazole
  • ZINC04860407
  • 2-[4-(4-Chloro-phenoxy)-3-nitro-phenyl]-5-phenyl-[1,3,4]oxadiazole
  • MLS000587989
  • SMR000212008
  • Oprea1_555605
  • STOCK2S-41026

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Loa Loa (eye worm) hypothetical protein 0.0042 0.0033 0.0214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Mycobacterium tuberculosis Probable lipase LipD 0.0042 0.0033 0.0149
Toxoplasma gondii target of rapamycin (TOR), putative 0.0081 0.0406 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0081 0.0406 0.039
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0043 0.0404
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0089 0.0489 0.7088
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0187 0.175
Mycobacterium tuberculosis Conserved protein 0.0042 0.0033 0.0149
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.011 0.0683 0.0668
Brugia malayi beta-lactamase family protein 0.0042 0.0033 0.0214
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0043 0.0027
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.004 0.0016 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0033 0.0051
Schistosoma mansoni inositol monophosphatase 0.0043 0.0043 0.0474
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0048 0.0093 0.0237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0093 0.1145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0048 0.0093 0.0076
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0033 0.0249
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0081 0.0406 0.039
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.011 0.0683 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.011 0.0683 0.6687
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0081 0.0406 1
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0033 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0048 0.0093 0.0237
Mycobacterium leprae conserved hypothetical protein 0.0042 0.0033 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0187 0.175
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.004 0.0016 0.0049
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1016 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0081 0.0406 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.011 0.0683 0.2071
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.011 0.0683 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0048 0.0093 0.1145
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0042 0.0033 0.0214
Brugia malayi hypothetical protein 0.0043 0.0049 0.0372
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0033 0.032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Onchocerca volvulus 0.006 0.0205 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0081 0.0406 0.587
Loa Loa (eye worm) hypothetical protein 0.004 0.0016 0.0049
Loa Loa (eye worm) phosphatidylinositol 3 0.011 0.0683 0.6687
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0053 0.0139 0.3148
Echinococcus multilocularis serine protein kinase ATM 0.0048 0.0093 0.0076
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0049 0.0556
Schistosoma mansoni fkbp-rapamycin associated protein 0.0048 0.0093 0.1209
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0406 0.3926
Entamoeba histolytica hypothetical protein 0.0043 0.0049 0.0487
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0093 0.1145
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0081 0.0406 0.587
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0187 0.175
Brugia malayi beta-lactamase 0.0042 0.0033 0.0214
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0081 0.0406 0.1209
Loa Loa (eye worm) hypothetical protein 0.0069 0.0298 0.2857
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.004 0.0016 0.0073
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.004 0.0016 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0081 0.0406 0.114
Loa Loa (eye worm) hypothetical protein 0.0042 0.0033 0.0214
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.004 0.0016 0.0073
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.011 0.0683 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Loa Loa (eye worm) beta-lactamase 0.0042 0.0033 0.0214
Loa Loa (eye worm) hypothetical protein 0.0048 0.0093 0.0809
Mycobacterium tuberculosis Probable lipase LipE 0.0042 0.0033 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Trichomonas vaginalis esterase, putative 0.0042 0.0033 0.0249
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1016 1
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0139 0.1838
Loa Loa (eye worm) hypothetical protein 0.0042 0.0033 0.0214
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0081 0.0406 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0406 0.3926
Entamoeba histolytica hypothetical protein 0.0048 0.0093 0.1145
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0081 0.0406 0.584
Mycobacterium leprae Probable lipase LipE 0.0042 0.0033 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0033 0.0214
Echinococcus multilocularis tumor protein p63 0.0408 0.3551 0.3541
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0042 0.0033 0.0149
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0043 0.0084
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0043 0.0404
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0042 0.0033 0.0149
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.011 0.0683 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0081 0.0406 0.3926
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0093 0.1145
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0042 0.0033 0.0214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0033 0.0051
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0081 0.0406 0.039
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0048 0.0093 0.1209
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0081 0.0406 0.1209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0093 0.1145
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0081 0.0406 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0093 0.1145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Mycobacterium tuberculosis Probable esterase LipL 0.0042 0.0033 0.0149
Echinococcus granulosus beta LACTamase domain containing family member 0.0042 0.0033 0.0017
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0081 0.0406 0.3926
Brugia malayi MH2 domain containing protein 0.0144 0.1016 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0081 0.0406 0.114
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.0043 0.5
Loa Loa (eye worm) inositol-1 0.0043 0.0043 0.0317
Echinococcus granulosus tumor protein p63 0.0408 0.3551 0.3541
Mycobacterium tuberculosis Conserved protein 0.0042 0.0033 0.0149
Entamoeba histolytica hypothetical protein 0.0043 0.0049 0.0487
Schistosoma mansoni phosphatidylinositol 4-kinase 0.004 0.0016 0.0073
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.011 0.0683 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0043 0.0404
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0081 0.0406 0.114
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0267 0.2196 1
Entamoeba histolytica hypothetical protein 0.0043 0.0049 0.0487
Entamoeba histolytica protein kinase rad3, putative 0.0048 0.0093 0.1145
Toxoplasma gondii ABC1 family protein 0.0042 0.0033 0.0426
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0048 0.0093 0.0076
Mycobacterium tuberculosis Probable hydrolase 0.0042 0.0033 0.0149
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.011 0.0683 0.0668
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0043 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Leishmania major hypothetical protein, conserved 0.0042 0.0033 0.0049
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0043 0.0027
Trypanosoma cruzi hypothetical protein, conserved 0.0375 0.3238 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0049 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0093 0.1145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Mycobacterium tuberculosis Conserved protein 0.0042 0.0033 0.0149
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0081 0.0406 0.114
Echinococcus multilocularis beta LACTamase domain containing family member 0.0042 0.0033 0.0017
Loa Loa (eye worm) hypothetical protein 0.0042 0.0033 0.0214
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0187 0.175
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0043 0.0079
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.011 0.0683 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.004 0.0016 0.0049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0081 0.0406 0.1209
Brugia malayi beta-lactamase family protein 0.0042 0.0033 0.0214
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.011 0.0683 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0093 0.1145
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0205 0.2883
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0049 0.0033
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0033 0.0249
Loa Loa (eye worm) hypothetical protein 0.0042 0.0033 0.0214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.011 0.0683 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Toxoplasma gondii FATC domain-containing protein 0.0048 0.0093 0.196
Entamoeba histolytica hypothetical protein 0.0043 0.0049 0.0487
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0081 0.0406 0.584
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0093 0.0809
Loa Loa (eye worm) hypothetical protein 0.006 0.0205 0.1928
Echinococcus granulosus serine protein kinase ATM 0.0048 0.0093 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0093 0.1145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0033 0.0249
Plasmodium falciparum phosphatidylinositol 3-kinase 0.004 0.0016 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0043 0.0084
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.011 0.0683 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0093 0.0809
Loa Loa (eye worm) hypothetical protein 0.0053 0.0139 0.1269
Trichomonas vaginalis penicillin-binding protein, putative 0.0042 0.0033 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0139 0.1838
Schistosoma mansoni hypothetical protein 0.0043 0.0049 0.0556
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1079 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0081 0.0406 1
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0033 0.0426
Brugia malayi Inositol-1 0.0043 0.0043 0.0317
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0048 0.0093 0.196
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.0043 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.011 0.0683 0.2071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0043 0.0692
Trypanosoma cruzi target of rapamycin kinase 3 0.0081 0.0406 0.1209
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0081 0.0406 0.1209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Trichomonas vaginalis D-aminoacylase, putative 0.0042 0.0033 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Entamoeba histolytica hypothetical protein 0.011 0.0683 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0042 0.0033 0.0149
Leishmania major phosphatidylinositol 3-kinase, putative 0.0081 0.0406 0.114
Leishmania major hypothetical protein, conserved 0.0396 0.3432 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0081 0.0406 0.584
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0053 0.0139 0.3148
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0043 0.0692
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0081 0.0406 0.039
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0042 0.0033 0.032
Schistosoma mansoni inositol monophosphatase 0.0043 0.0043 0.0474

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 14.581 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 20.5962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 23.1093 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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