Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0479 | 0.7463 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.034 | 0.4726 | 0.6311 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0479 | 0.7463 | 1 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0268 | 0.3328 | 0.446 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0479 | 0.7463 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.034 | 0.4726 | 0.6311 |
Onchocerca volvulus | 0.0561 | 0.907 | 0.9285 | |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0101 | 0.0042 | 0.0057 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.021 | 0.2189 | 0.2893 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0479 | 0.7463 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.032 | 0.4333 | 0.5806 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0108 | 0.0179 | 0.024 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0268 | 0.3328 | 0.4428 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0257 | 0.3096 | 0.4115 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.034 | 0.4726 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.032 | 0.4333 | 0.5806 |
Loa Loa (eye worm) | hypothetical protein | 0.0539 | 0.8636 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0231 | 0.2601 | 0.3485 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.021 | 0.2189 | 0.2933 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.034 | 0.4726 | 0.6332 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0229 | 0.2559 | 0.3762 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0101 | 0.0042 | 0.0057 |
Brugia malayi | AMP-binding enzyme family protein | 0.0301 | 0.3968 | 0.3968 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.034 | 0.4726 | 0.6332 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0301 | 0.3968 | 0.3915 |
Mycobacterium ulcerans | polyketide synthase | 0.034 | 0.4726 | 0.6332 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.032 | 0.4333 | 0.5806 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.034 | 0.4726 | 0.6332 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.034 | 0.4726 | 0.6332 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0581 | 0.9464 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0261 | 0.3179 | 0.426 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.021 | 0.2189 | 0.2933 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.032 | 0.4333 | 0.5806 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.032 | 0.4333 | 0.5782 |
Mycobacterium ulcerans | thioesterase TesA | 0.0268 | 0.3328 | 0.446 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0257 | 0.3096 | 0.4148 |
Loa Loa (eye worm) | fatty acid synthase | 0.0318 | 0.4299 | 0.4347 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.013 | 0.0613 | 0.0822 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.032 | 0.4333 | 0.5782 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.032 | 0.4333 | 0.4333 |
Mycobacterium ulcerans | polyketide synthase | 0.032 | 0.4333 | 0.5806 |
Mycobacterium ulcerans | thioesterase | 0.0268 | 0.3328 | 0.446 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0209 | 0.216 | 0.2612 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.032 | 0.4333 | 0.5806 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.034 | 0.4726 | 0.6332 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0183 | 0.1652 | 0.2214 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.032 | 0.4333 | 0.5806 |
Loa Loa (eye worm) | hypothetical protein | 0.0178 | 0.1549 | 0.0762 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0257 | 0.3096 | 0.4148 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0312 | 0.4189 | 0.5614 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0312 | 0.4189 | 0.5614 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.034 | 0.4726 | 0.6311 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0301 | 0.3968 | 0.5316 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.032 | 0.4333 | 0.5806 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = -13 % | Inactivation process of guinea pig cardiac Na channels expressed in xenopus oocytes was determined by measuring increase in current integral in presence of compound versus control at 10 uM | ChEMBL. | 7629798 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.