Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | synuclein, alpha (non A4 component of amyloid precursor) | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | K(lysine) acetyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0365 | 1 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0051 | 0.0135 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0365 | 1 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0175 | 0.4026 | 0.3418 |
Loa Loa (eye worm) | acetyltransferase | 0.0175 | 0.4026 | 0.3418 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0051 | 0.0135 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0175 | 0.4026 | 0.3418 |
Onchocerca volvulus | 0.0365 | 1 | 0.5 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.0365 | 1 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0047 | 0 | 0.5 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0047 | 0 | 0.5 |
Giardia lamblia | Kinase, CDC7 | 0.0365 | 1 | 1 |
Loa Loa (eye worm) | CDC7 protein kinase | 0.0365 | 1 | 1 |
Echinococcus granulosus | CDC7 cell division cycle 7 | 0.0365 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0365 | 1 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.017 | 0.3871 | 0.3787 |
Echinococcus multilocularis | CDC7 cell division cycle 7 | 0.0365 | 1 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0175 | 0.4026 | 0.3418 |
Onchocerca volvulus | 0.0365 | 1 | 0.5 | |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.0923 | 0.0799 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0051 | 0.0135 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1413 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.