Detailed information for compound 143709

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 269.469 | Formula: C16H35N3
  • H donors: 3 H acceptors: 0 LogP: 2.93 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCNCCCNCCCNCC1CCCCCC1
  • InChi: 1S/C16H35N3/c1-2-17-11-7-12-18-13-8-14-19-15-16-9-5-3-4-6-10-16/h16-19H,2-15H2,1H3
  • InChiKey: BARPIBGVXNIVSG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0058 0.0303 0.0676
Loa Loa (eye worm) carbonic anhydrase 3 0.0393 0.4102 0.657
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0058 0.0303 0.0676
Schistosoma mansoni hypothetical protein 0.0058 0.0303 0.0376
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0058 0.0303 0.0376
Loa Loa (eye worm) TYRA-2 protein 0.0058 0.0303 0.0486
Loa Loa (eye worm) hypothetical protein 0.0571 0.6119 0.98
Schistosoma mansoni histamine h1 receptor 0.0058 0.0303 0.0376
Entamoeba histolytica MIR domain protein 0.0094 0.0711 0.5
Echinococcus granulosus neuropeptides capa receptor 0.0058 0.0303 0.0676
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Brugia malayi hypothetical protein 0.0058 0.0303 0.0303
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0058 0.0303 0.0303
Onchocerca volvulus Neuropeptide F receptor homolog 0.0058 0.0303 0.1253
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0005 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0005 0.0005
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0005 0.0011
Echinococcus multilocularis carbonic anhydrase 0.0294 0.2985 0.6645
Loa Loa (eye worm) hypothetical protein 0.0031 0.0005 0.0008
Schistosoma mansoni hypothetical protein 0.0058 0.0303 0.0376
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0058 0.0303 0.0676
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0303 0.0676
Echinococcus multilocularis g protein coupled receptor 0.0058 0.0303 0.0676
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0058 0.0303 0.0676
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0058 0.0303 0.0676
Brugia malayi G-protein coupled receptor 0.0058 0.0303 0.0303
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0005 0.0008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0005 0.0005
Schistosoma mansoni carbonic anhydrase-related 0.0294 0.2985 0.3698
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0303 0.0676
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0058 0.0303 0.0676
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0005 0.0005
Loa Loa (eye worm) melatonin receptor type 1A 0.0058 0.0303 0.0486
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0058 0.0303 0.0676
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0058 0.0303 0.0676
Loa Loa (eye worm) hypothetical protein 0.0222 0.2172 0.3479
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0058 0.0303 0.0676
Loa Loa (eye worm) G-protein coupled receptor 0.0058 0.0303 0.0486
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.2086 0.3342
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0058 0.0303 0.0676
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0005 0.0008
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0005 0.0006
Echinococcus granulosus biogenic amine 5HT receptor 0.0058 0.0303 0.0676
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0005 0.0006
Brugia malayi ecdysteroid receptor 0.0031 0.0005 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0303 0.0676
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Schistosoma mansoni neuropeptide receptor 0.0058 0.0303 0.0376
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0303 0.0676
Echinococcus granulosus g-protein coupled receptor 0.0058 0.0303 0.0676
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0058 0.0303 0.0303
Echinococcus granulosus G protein coupled receptor 139 0.0058 0.0303 0.0676
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.025 0.2488 0.3985
Echinococcus granulosus neuropeptide receptor 0.0058 0.0303 0.0676
Echinococcus granulosus alpha 1A adrenergic receptor 0.0058 0.0303 0.0676
Echinococcus granulosus biogenic amine 5HT receptor 0.0058 0.0303 0.0676
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0005 0.0008
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0005 0.0006
Brugia malayi nuclear receptor NHR-88 0.0031 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.0094 0.0711 0.0881
Plasmodium falciparum carbonic anhydrase 0.0294 0.2985 0.5
Echinococcus granulosus neuropeptide FF receptor 2 0.0058 0.0303 0.0676
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Schistosoma mansoni neuropeptide receptor 0.0058 0.0303 0.0376
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0303 0.0676
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0303 0.0676
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Echinococcus multilocularis ryanodine receptor 44f 0.0331 0.3407 0.7585
Echinococcus granulosus stromal cell derived factor 2 0.0094 0.0711 0.1584
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1512 0.4508
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Echinococcus granulosus carbonic anhydrase 0.0294 0.2985 0.6645
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0303 0.0376
Onchocerca volvulus 0.0058 0.0303 0.1253
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0058 0.0303 0.0676
Onchocerca volvulus 0.0094 0.0711 0.2936
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0005 0.0011
Loa Loa (eye worm) ryanodine receptor 0.0161 0.1479 0.2368
Schistosoma mansoni amine GPCR 0.0058 0.0303 0.0376
Brugia malayi neuropeptide F receptor 0.0058 0.0303 0.0303
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0005 0.0006
Onchocerca volvulus 0.0058 0.0303 0.1253
Echinococcus multilocularis ryanodine receptor 44f 0.0427 0.4492 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0186 0.023
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.2488 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0294 0.2985 0.2985
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0303 0.0676
Echinococcus granulosus hypothetical protein 0.0058 0.0303 0.0676
Schistosoma mansoni biogenic amine (5HT) receptor 0.0058 0.0303 0.0376
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0058 0.0303 0.0303
Echinococcus multilocularis G-protein coupled receptor, putative 0.0058 0.0303 0.0676
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Loa Loa (eye worm) neuropeptide F receptor 0.0058 0.0303 0.0486
Echinococcus multilocularis neuropeptides capa receptor 0.0058 0.0303 0.0676
Loa Loa (eye worm) MIR domain-containing protein 0.0094 0.0711 0.1139
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0186 0.023
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0058 0.0303 0.0376
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0005 0.0011
Onchocerca volvulus 0.0058 0.0303 0.1253
Echinococcus granulosus neuropeptide Y receptor 0.0058 0.0303 0.0676
Brugia malayi hypothetical protein 0.0058 0.0303 0.0303
Brugia malayi RE15519p 0.0058 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0031 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Schistosoma mansoni amine GPCR 0.0058 0.0303 0.0376
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0005 0.002
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0058 0.0303 0.0376
Echinococcus granulosus neuropeptide s receptor 0.0058 0.0303 0.0676
Echinococcus multilocularis somatostatin receptor 0.0058 0.0303 0.0676
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Echinococcus granulosus 7tm_1 domain containing protein 0.0058 0.0303 0.0676
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1613 0.5073
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0303 0.0676
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0005 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1512 0.4508
Toxoplasma gondii hypothetical protein 0.0294 0.2985 1
Schistosoma mansoni biogenic amine receptor 0.0058 0.0303 0.0376
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0303 0.0376
Echinococcus multilocularis carbonic anhydrase 0.0294 0.2985 0.6645
Brugia malayi hypothetical protein 0.0058 0.0303 0.0303
Brugia malayi Dopamine receptor protein 1 0.0058 0.0303 0.0303
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0303 0.0376
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 0.0303 0.0676
Echinococcus multilocularis carbonic anhydrase II 0.0393 0.4102 0.9132
Brugia malayi MIR domain containing protein 0.0094 0.0711 0.0711
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0005 0.0011
Echinococcus multilocularis allatostatin A receptor 0.0058 0.0303 0.0676
Onchocerca volvulus 0.0058 0.0303 0.1253
Onchocerca volvulus 0.0031 0.0005 0.002
Echinococcus multilocularis G protein coupled receptor 139 0.0058 0.0303 0.0676
Echinococcus multilocularis neuropeptide receptor 0.0058 0.0303 0.0676
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0005 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1512 0.4508
Schistosoma mansoni amine GPCR 0.0058 0.0303 0.0376
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Schistosoma mansoni myosin xvIII 0.0058 0.0303 0.0376
Brugia malayi hypothetical protein 0.0058 0.0303 0.0303
Echinococcus multilocularis serotonin receptor 0.0058 0.0303 0.0676
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.0303 0.0376
Brugia malayi hypothetical protein 0.0058 0.0303 0.0303
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0005 0.0008
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0294 0.2985 0.2985
Echinococcus granulosus orexin receptor type 2 0.0058 0.0303 0.0676
Brugia malayi putative neuropeptide receptor 0.0058 0.0303 0.0303
Schistosoma mansoni hypothetical protein 0.0294 0.2985 0.3698
Echinococcus multilocularis fmrfamide receptor 0.0058 0.0303 0.0676
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.2488 1
Echinococcus multilocularis fmrfamide receptor 0.0058 0.0303 0.0676
Brugia malayi ORL1-like opioid receptor 0.0058 0.0303 0.0303
Trichomonas vaginalis set domain proteins, putative 0.0245 0.2423 0.9633
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0005 0.0011
Schistosoma mansoni twik family of potassium channels-related 0.0222 0.2172 0.2691
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0005 0.0011
Echinococcus granulosus g protein coupled receptor 0.0058 0.0303 0.0676
Onchocerca volvulus 0.0058 0.0303 0.1253
Brugia malayi Melatonin receptor type 1A 0.0058 0.0303 0.0303
Echinococcus multilocularis neuropeptides capa receptor 0.0058 0.0303 0.0676
Schistosoma mansoni carbonic anhydrase 0.0294 0.2985 0.3698
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0005 0.0006
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0504 0.536 1
Schistosoma mansoni neuropeptide receptor 0.0058 0.0303 0.0376
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0005 0.0005
Brugia malayi steroid hormone receptor 0.0031 0.0005 0.0005
Echinococcus granulosus sex peptide receptor 0.0058 0.0303 0.0676
Loa Loa (eye worm) hypothetical protein 0.0582 0.6243 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0303 0.0376
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0186 0.0414
Schistosoma mansoni adenoreceptor 0.0058 0.0303 0.0376
Echinococcus granulosus ryanodine receptor 44f 0.0427 0.4492 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0186 0.023
Echinococcus granulosus carbonic anhydrase 0.0294 0.2985 0.6645
Echinococcus granulosus peptide allatostatin:somatostatin 0.0058 0.0303 0.0676
Echinococcus granulosus allatostatin A receptor 0.0058 0.0303 0.0676
Echinococcus multilocularis neuropeptide Y receptor 0.0058 0.0303 0.0676
Echinococcus multilocularis g-protein coupled receptor 0.0058 0.0303 0.0676
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0186 0.0414
Brugia malayi follicle stimulating hormone receptor 0.0058 0.0303 0.0303
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0005 0.002
Echinococcus granulosus tm gpcr rhodopsin 0.0058 0.0303 0.0676
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0005 0.0006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0186 0.0414
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1512 0.4508
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Onchocerca volvulus 0.0058 0.0303 0.1253
Echinococcus granulosus ryanodine receptor 44f 0.0331 0.3407 0.7585
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Brugia malayi GnHR receptor homolog 0.0058 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Schistosoma mansoni carbonic anhydrase-related 0.0294 0.2985 0.3698
Echinococcus multilocularis neuropeptide Y receptor 0.0058 0.0303 0.0676
Echinococcus multilocularis neuropeptide s receptor 0.0058 0.0303 0.0676
Schistosoma mansoni opsin-like receptor 0.0058 0.0303 0.0376
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0005 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0005 0.0005
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.0222 0.2172 0.4836
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0058 0.0303 0.0486
Echinococcus granulosus 7TM GPCR rhodopsin 0.0058 0.0303 0.0676
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0393 0.4102 0.4102
Echinococcus granulosus Two pore potassium channel protein sup 9 0.0222 0.2172 0.4836
Brugia malayi G protein-coupled receptor 0.0058 0.0303 0.0303
Brugia malayi Serotonin receptor 0.0058 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0031 0.0005 0.0008
Brugia malayi hypothetical protein 0.0058 0.0303 0.0303
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0005 0.0005
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0058 0.0303 0.0676
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0597 0.642 0.642
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0303 0.0376
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0294 0.2985 0.2985
Schistosoma mansoni growth hormone secretagogue receptor 0.0058 0.0303 0.0376
Echinococcus granulosus neuropeptides capa receptor 0.0058 0.0303 0.0676
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0005 0.0008
Brugia malayi larval opioid receptor 0.0058 0.0303 0.0303
Schistosoma mansoni coup transcription factor 0.0031 0.0005 0.0006
Brugia malayi hypothetical protein 0.0058 0.0303 0.0303
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0294 0.2985 0.2985
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.2488 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0058 0.0303 0.0376
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0005 0.0005
Brugia malayi Tachykinin-like peptides receptor 99D 0.0058 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0058 0.0303 0.0376
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0005 0.0005
Echinococcus granulosus dro:myosuppressin receptor 0.0058 0.0303 0.0676
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Loa Loa (eye worm) hypothetical protein 0.0209 0.202 0.3236
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0005 0.0005
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0005 0.0006
Echinococcus granulosus g protein coupled receptor 0.0058 0.0303 0.0676
Onchocerca volvulus 0.0058 0.0303 0.1253
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0005 0.0005
Loa Loa (eye worm) G-protein coupled receptor 0.0058 0.0303 0.0486
Loa Loa (eye worm) hypothetical protein 0.0031 0.0005 0.0008
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0005 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0005 0.0008
Loa Loa (eye worm) hypothetical protein 0.0427 0.4492 0.7194
Echinococcus multilocularis carbonic anhydrase 0.0294 0.2985 0.6645
Echinococcus granulosus carbonic anhydrase 0.0294 0.2985 0.6645
Schistosoma mansoni opsin-like receptor 0.0058 0.0303 0.0376
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0058 0.0303 0.0676
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1613 0.5073
Schistosoma mansoni alpha-1 adrenergic receptor 0.0058 0.0303 0.0376
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 0.0303 0.0676
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Onchocerca volvulus 0.0058 0.0303 0.1253
Onchocerca volvulus 0.0058 0.0303 0.1253
Echinococcus multilocularis orexin receptor type 2 0.0058 0.0303 0.0676
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0058 0.0303 0.0376
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0005 0.0011
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0058 0.0303 0.0676
Brugia malayi hypothetical protein 0.0058 0.0303 0.0303
Schistosoma mansoni biogenic amine receptor 0.0058 0.0303 0.0376
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0393 0.4102 0.4102
Loa Loa (eye worm) hypothetical protein 0.0031 0.0005 0.0008
Echinococcus granulosus somatostatin receptor 0.0058 0.0303 0.0676
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0058 0.0303 0.1253
Schistosoma mansoni neuropeptide F-like receptor 0.0058 0.0303 0.0376
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0005 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0005 0.0011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0186 0.0186
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0504 0.536 1
Echinococcus granulosus tm gpcr rhodopsin 0.0058 0.0303 0.0676
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.2488 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0005 0.0005
Schistosoma mansoni ryanodine receptor related 0.0597 0.642 0.7954
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1512 0.4508
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0058 0.0303 0.0486
Plasmodium vivax SET domain protein, putative 0.0031 0 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0058 0.0303 0.0303
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1512 0.4508
Schistosoma mansoni biogenic amine (5HT) receptor 0.0058 0.0303 0.0376
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0058 0.0303 0.0303
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0186 0.0298
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0005 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0303 0.0676
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Echinococcus multilocularis g protein coupled receptor 0.0058 0.0303 0.0676
Loa Loa (eye worm) hypothetical protein 0.0222 0.2172 0.3479
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0303 0.0676
Brugia malayi G protein-coupled receptor F59B2.13 0.0058 0.0303 0.0303
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.2488 1
Onchocerca volvulus 0.0058 0.0303 0.1253
Echinococcus granulosus serotonin receptor 0.0058 0.0303 0.0676
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0393 0.4102 0.5082
Echinococcus granulosus neuropeptide receptor A26 0.0058 0.0303 0.0676
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0005 0.002
Brugia malayi hypothetical protein 0.0058 0.0303 0.0303
Onchocerca volvulus 0.0245 0.2423 1
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.0222 0.2172 0.2172
Echinococcus multilocularis neuropeptide receptor A26 0.0058 0.0303 0.0676
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0303 0.0676
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0393 0.4102 0.5082
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0058 0.0303 0.0376
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0303 0.0376
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0058 0.0303 0.0676
Schistosoma mansoni neuropeptide receptor 0.0058 0.0303 0.0376
Loa Loa (eye worm) neuropeptide F receptor 0.0058 0.0303 0.0486
Onchocerca volvulus 0.0058 0.0303 0.1253
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0303 0.0676
Brugia malayi nuclear hormone receptor 0.0031 0.0005 0.0005
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0393 0.4102 0.657
Brugia malayi Pre-SET motif family protein 0.0215 0.2086 0.2086
Echinococcus multilocularis neuropeptide receptor 0.0058 0.0303 0.0676
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.0303 0.0376
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0058 0.0303 0.0376
Loa Loa (eye worm) hypothetical protein 0.0294 0.2985 0.478
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.1512 0.4508
Echinococcus multilocularis serotonin receptor 0.0058 0.0303 0.0676
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.1512 0.6242
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0058 0.0303 0.0376
Onchocerca volvulus 0.0058 0.0303 0.1253
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0058 0.0303 0.0676
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0005 0.0011
Schistosoma mansoni opsin-like receptor 0.0058 0.0303 0.0376
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0303 0.0676
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0303 0.0376
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Loa Loa (eye worm) hypothetical protein 0.0294 0.2985 0.478
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Leishmania major carbonic anhydrase-like protein 0.0393 0.4102 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0005 0.0006
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0005 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0005 0.0005
Onchocerca volvulus 0.0058 0.0303 0.1253
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0005 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0058 0.0303 0.0676
Echinococcus granulosus neuropeptide Y receptor 0.0058 0.0303 0.0676
Echinococcus multilocularis rhodopsin orphan GPCR 0.0058 0.0303 0.0676
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0294 0.2985 0.478
Schistosoma mansoni biogenic amine receptor 0.0058 0.0303 0.0376
Echinococcus granulosus neuropeptide receptor 0.0058 0.0303 0.0676
Schistosoma mansoni hypothetical protein 0.0058 0.0303 0.0376
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0058 0.0303 0.0376
Brugia malayi Dopamine receptor protein 2 0.0058 0.0303 0.0303
Echinococcus multilocularis neuropeptide FF receptor 2 0.0058 0.0303 0.0676
Echinococcus multilocularis stromal cell derived factor 2 0.0094 0.0711 0.1584
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0005 0.0008
Echinococcus multilocularis g protein coupled receptor 0.0058 0.0303 0.0676
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Onchocerca volvulus 0.0058 0.0303 0.1253
Echinococcus granulosus carbonic anhydrase II 0.0393 0.4102 0.9132
Loa Loa (eye worm) hypothetical protein 0.0486 0.5159 0.8263
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0058 0.0303 0.0676
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0005 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0303 0.0376
Brugia malayi sulfakinin receptor protein 0.0058 0.0303 0.0303
Schistosoma mansoni neuropeptide F-like receptor 0.0058 0.0303 0.0376
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Loa Loa (eye worm) hypothetical protein 0.0031 0.0005 0.0008
Echinococcus granulosus tm gpcr rhodopsin 0.0058 0.0303 0.0676
Echinococcus multilocularis sex peptide receptor 0.0058 0.0303 0.0676
Brugia malayi hypothetical protein 0.0058 0.0303 0.0303
Onchocerca volvulus 0.0058 0.0303 0.1253
Brugia malayi AKH receptor 0.0058 0.0303 0.0303
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Brugia malayi neuropeptide F receptor 0.0058 0.0303 0.0303
Schistosoma mansoni carbonic anhydrase-related 0.0294 0.2985 0.3698
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0005 0.0011
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.2488 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0005 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0058 0.0303 0.0376
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.025 0.2488 0.2488
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0005 0.0008
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0743 0.8071 1
Schistosoma mansoni hypothetical protein 0.0058 0.0303 0.0376
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0058 0.0303 0.0676
Schistosoma mansoni ryanodine receptor 1 skeletal muscle 0.0161 0.1479 0.1832
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0058 0.0303 0.0486
Loa Loa (eye worm) hypothetical protein 0.0031 0.0005 0.0008
Onchocerca volvulus 0.0058 0.0303 0.1253
Echinococcus multilocularis dro:myosuppressin receptor 0.0058 0.0303 0.0676
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0005 0.0006
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Echinococcus granulosus g protein coupled receptor 0.0058 0.0303 0.0676
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0294 0.2985 0.2985
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0058 0.0303 0.0486
Echinococcus granulosus tachykinin peptides receptor 99D 0.0058 0.0303 0.0676
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0486 0.5159 0.6392
Loa Loa (eye worm) hypothetical protein 0.0294 0.2985 0.478
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Schistosoma mansoni amine GPCR 0.0058 0.0303 0.0376
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0058 0.0303 0.0376
Brugia malayi G-protein coupled receptor 0.0058 0.0303 0.0303
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0058 0.0303 0.0303
Brugia malayi Serotonin receptor 0.0058 0.0303 0.0303
Echinococcus granulosus fmrfamide receptor 0.0058 0.0303 0.0676
Schistosoma mansoni amine GPCR 0.0058 0.0303 0.0376
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0058 0.0303 0.0486
Brugia malayi Dopamine receptor 0.0058 0.0303 0.0303
Onchocerca volvulus 0.0058 0.0303 0.1253
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Loa Loa (eye worm) hypothetical protein 0.0058 0.0303 0.0486
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0186 0.0414
Schistosoma mansoni neuropeptide f receptor 76f 0.0058 0.0303 0.0376

Activities

Activity type Activity value Assay description Source Reference
Amount (functional) > 20 nM (mg of protein)-1 Effect of exposure of H157 non-SCLC (<10 microM) for 96-h, and accumulation of compound was determined ChEMBL. 11141084
Amount (functional) > 20 nM (mg of protein)-1 Effect of exposure of H157 non-SCLC (<10 microM) for 96-h, and accumulation of compound was determined ChEMBL. 11141084
Cytokinetic response (functional) = 0 Cytokinetic effect on H157 non-small-cell lung tumor line (non-SCLC) after 96-h treatment; Cytotoxic at <10 microM ChEMBL. 11141084
Cytokinetic response (functional) = 0 Cytokinetic effects on H82 small-cell lung tumor line (SCLC) after 96-h treatment; Cytostatic at <= 10 microM ChEMBL. 11141084
Effect on polyamine pools (functional) 0 Effect of exposure of H157 non-SCLC to compound (<10 microM) for 96-h, on natural polyamines and accumulation of the compound; Decrease ChEMBL. 11141084
Induction (binding) > 500 Effect of 10 uM on spermine/spermidine-N-acetyltransferase (SSAT) induction in non-SCLC cells ChEMBL. 11141084
Induction (binding) > 500 Effect of 10 uM on spermine/spermidine-N-acetyltransferase (SSAT) induction in non-SCLC cells ChEMBL. 11141084

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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