Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0403 | 0.4022 | 0.5414 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0307 | 0.2594 | 0.3914 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0419 | 0.4255 | 0.5728 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0136 | 0.0045 | 0.006 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0446 | 0.4654 | 0.6243 |
Mycobacterium ulcerans | thioesterase | 0.036 | 0.3374 | 0.4542 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0418 | 0.4247 | 0.5717 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0419 | 0.4255 | 0.5728 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0418 | 0.4247 | 0.5717 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0136 | 0.0043 | 0.0058 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0273 | 0.2082 | 0.2803 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0335 | 0.3002 | 0.4041 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0403 | 0.4022 | 0.3985 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0419 | 0.4255 | 0.5728 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0446 | 0.4654 | 0.6265 |
Mycobacterium ulcerans | thioesterase TesA | 0.036 | 0.3374 | 0.4542 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0633 | 0.7428 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0403 | 0.4022 | 0.4022 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0446 | 0.4654 | 0.6265 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0419 | 0.4255 | 0.5728 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0419 | 0.4255 | 0.5704 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0633 | 0.7428 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.034 | 0.3086 | 0.4154 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0273 | 0.2082 | 0.2803 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0136 | 0.0043 | 0.0058 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.028 | 0.2189 | 0.2718 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0633 | 0.7428 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0245 | 0.1675 | 0.2255 |
Loa Loa (eye worm) | fatty acid synthase | 0.0426 | 0.4358 | 0.4425 |
Onchocerca volvulus | 0.0751 | 0.9194 | 0.9285 | |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0778 | 0.9593 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0446 | 0.4654 | 0.6265 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0446 | 0.4654 | 0.6265 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0419 | 0.4255 | 0.5728 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.1434 | 0.0597 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.036 | 0.3374 | 0.451 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0175 | 0.0622 | 0.0837 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0335 | 0.3002 | 0.4041 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0419 | 0.4255 | 0.5728 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0335 | 0.3002 | 0.4006 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0446 | 0.4654 | 0.6265 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0273 | 0.2082 | 0.2761 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.036 | 0.3374 | 0.4542 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0419 | 0.4255 | 0.4255 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0446 | 0.4654 | 0.6265 |
Mycobacterium ulcerans | polyketide synthase | 0.0419 | 0.4255 | 0.5728 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0419 | 0.4255 | 0.5704 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0446 | 0.4654 | 0.6243 |
Loa Loa (eye worm) | hypothetical protein | 0.0713 | 0.8617 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0633 | 0.7428 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0446 | 0.4654 | 0.6243 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.031 | 0.2636 | 0.3549 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0419 | 0.4255 | 0.5728 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0446 | 0.4654 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 160 uM | PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.