Detailed information for compound 1441255

Basic information

Technical information
  • TDR Targets ID: 1441255
  • Name: ethyl 4-(2,4-dichlorophenyl)-1,6-dimethyl-2-s ulfanylidene-3,4-dihydropyrimidine-5-carboxyl ate
  • MW: 359.271 | Formula: C15H16Cl2N2O2S
  • H donors: 0 H acceptors: 1 LogP: 3.65 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)C1=C(C)N(C)C(=NC1c1ccc(cc1Cl)Cl)S
  • InChi: 1S/C15H16Cl2N2O2S/c1-4-21-14(20)12-8(2)19(3)15(22)18-13(12)10-6-5-9(16)7-11(10)17/h5-7,13H,4H2,1-3H3,(H,18,22)
  • InChiKey: LWLWWVULVLBARG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ethyl 4-(2,4-dichlorophenyl)-1,6-dimethyl-2-thioxo-3,4-dihydropyrimidine-5-carboxylate
  • 4-(2,4-dichlorophenyl)-1,6-dimethyl-2-thioxo-3,4-dihydropyrimidine-5-carboxylic acid ethyl ester
  • SMR000225289
  • ethyl 4-(2,4-dichlorophenyl)-1,6-dimethyl-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
  • AF-399/40828078
  • MLS000700406

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 3 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica diacylglycerol kinase, putative 0.0026 0.0187 0.339
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0026 0.0193 0.0193
Brugia malayi Protein kinase domain containing protein 0.0017 0.0064 0.0066
Brugia malayi Protein kinase domain containing protein 0.0017 0.0064 0.0066
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0064 0.0065
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0208 0.2669 0.2695
Schistosoma mansoni protein kinase C 0.0026 0.0187 0.0187
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0064 0.0065
Echinococcus granulosus tyrosine protein kinase Fyn 0.0026 0.0193 0.0193
Entamoeba histolytica hypothetical protein 0.0026 0.0187 0.339
Loa Loa (eye worm) hypothetical protein 0.0027 0.0205 0.0207
Echinococcus granulosus unc 13 munc13 0.0026 0.0187 0.0187
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0027 0.0197 0.0197
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0036 0.0319 0.0319
Onchocerca volvulus 0.0017 0.0064 0.0229
Loa Loa (eye worm) hypothetical protein 0.0017 0.0064 0.0065
Schistosoma mansoni tyrosine kinase 0.0017 0.0064 0.0064
Echinococcus granulosus tyrosine kinase 0.0017 0.0064 0.0064
Echinococcus multilocularis growth factor receptor bound protein 2 0.0019 0.0096 0.0096
Brugia malayi SH2 domain containing protein 0.0017 0.0064 0.0066
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0026 0.0193 0.0193
Echinococcus granulosus activin receptor type 0.0159 0.1996 0.1996
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0026 0.0193 0.0193
Echinococcus granulosus tyrosine protein kinase Fyn 0.0026 0.0193 0.0193
Entamoeba histolytica hypothetical protein 0.0043 0.0426 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0036 0.0319 0.0319
Schistosoma mansoni protein kinase C mu 0.0026 0.0187 0.0187
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0084 0.0979 0.0979
Schistosoma mansoni tyrosine kinase 0.0151 0.189 0.189
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0017 0.0064 0.0064
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0036 0.0319 0.0322
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0036 0.0319 0.0319
Echinococcus granulosus tyrosine protein kinase ABL1 0.0017 0.0064 0.0064
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0152 0.1899 0.1899
Echinococcus granulosus Protein kinase C brain isozyme 0.0027 0.0197 0.0197
Onchocerca volvulus 0.0026 0.0181 0.0647
Brugia malayi Furin-like cysteine rich region family protein 0.0151 0.189 0.1959
Echinococcus granulosus tyrosine protein kinase Src64B 0.0026 0.0193 0.0193
Brugia malayi diacylglycerol kinase 0.0026 0.0187 0.0193
Brugia malayi protein kinase C3,putative 0.0027 0.0197 0.0205
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0078
Schistosoma mansoni tyrosine kinase 0.0077 0.0881 0.0881
Brugia malayi hypothetical protein 0.0043 0.0426 0.0441
Echinococcus granulosus protein kinase c epsilon type 0.0027 0.0197 0.0197
Echinococcus multilocularis TGF beta receptor type 1 0.0335 0.4401 0.4401
Brugia malayi Protein kinase domain containing protein 0.0208 0.2669 0.2767
Schistosoma mansoni tyrosine kinase 0.0053 0.055 0.055
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0197 0.0197
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0026 0.0187 0.0187
Echinococcus multilocularis protein kinase c iota type 0.0027 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0026 0.0181 0.0183
Echinococcus granulosus epidermal growth factor receptor 0.0084 0.0979 0.0979
Entamoeba histolytica diacylglycerol kinase, putative 0.0026 0.0187 0.339
Brugia malayi hypothetical protein 0.0207 0.2658 0.2755
Echinococcus granulosus protein kinase c eta type 0.0026 0.0187 0.0187
Schistosoma mansoni tyrosine kinase 0.0026 0.0193 0.0193
Brugia malayi Protein kinase domain containing protein 0.0017 0.0064 0.0066
Schistosoma mansoni growth factor receptor-bound protein 0.0019 0.0096 0.0096
Echinococcus multilocularis c src tyrosine kinase 0.0026 0.0193 0.0193
Echinococcus granulosus N chimaerin 0.0036 0.0319 0.0319
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0096 0.0099
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0018 0.008 0.0083
Onchocerca volvulus 0.0017 0.0064 0.0229
Brugia malayi Variant SH3 domain containing protein 0.0019 0.0096 0.0099
Onchocerca volvulus 0.0017 0.0064 0.0229
Schistosoma mansoni tyrosine kinase 0.0084 0.0979 0.0979
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0064 0.0065
Echinococcus granulosus tyrosine protein kinase shark 0.0017 0.0064 0.0064
Schistosoma mansoni unc-13 (munc13) 0.0026 0.0187 0.0187
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0342 0.4488 0.4532
Echinococcus multilocularis tyrosine protein kinase shark 0.0017 0.0064 0.0064
Schistosoma mansoni tyrosine kinase 0.0053 0.055 0.055
Brugia malayi SH2 domain containing protein 0.0017 0.0064 0.0066
Brugia malayi Raf kinase 0.072 0.9647 1
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0064 0.0065
Schistosoma mansoni serine/threonine protein kinase 0.0746 1 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0026 0.0193 0.0193
Echinococcus multilocularis tyrosine protein kinase Blk 0.0017 0.0064 0.0064
Echinococcus granulosus insulin receptor 0.0053 0.055 0.055
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0026 0.0187 0.0188
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0026 0.0193 0.0193
Schistosoma mansoni protein kinase 0.0335 0.4401 0.4401
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0019 0.0096 0.0097
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0019 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0026 0.0187 0.0188
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0026 0.0187 0.0187
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0027 0.0197 0.0199
Leishmania major protein kinase, putative 0.0013 0.0013 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0064 0.0065
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0026 0.0185 0.0187
Loa Loa (eye worm) hypothetical protein 0.0026 0.0187 0.0188
Schistosoma mansoni tyrosine kinase 0.0026 0.0193 0.0193
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0426 0.0426
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0064 0.0065
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0018 0.008 0.0083
Schistosoma mansoni tyrosine kinase 0.0026 0.0193 0.0193
Echinococcus granulosus tyrosine kinase 0.0017 0.0064 0.0064
Onchocerca volvulus 0.0026 0.0187 0.0666
Echinococcus multilocularis protein kinase 0.012 0.1463 0.1463
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0155 0.1945 0.1945
Echinococcus multilocularis Rac GTPase activating protein 1 0.0026 0.0187 0.0187
Echinococcus multilocularis myotubularin protein 13 0.0027 0.0205 0.0205
Onchocerca volvulus Protein cycle homolog 0.0018 0.008 0.0287
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0026 0.0193 0.0193
Echinococcus multilocularis activin receptor type 0.0159 0.1996 0.1996
Echinococcus granulosus tyrosine protein kinase Srms 0.0017 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0026 0.0187 0.0188
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0019 0.0096 0.0097
Brugia malayi RhoGAP domain containing protein 0.0036 0.0319 0.0331
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0155 0.1945 0.1945
Echinococcus multilocularis unc 13 (munc13) 0.0026 0.0187 0.0187
Echinococcus granulosus growth factor receptor bound protein 2 0.0019 0.0096 0.0096
Echinococcus multilocularis protein kinase c eta type 0.0026 0.0187 0.0187
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0026 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0078
Loa Loa (eye worm) hypothetical protein 0.0026 0.0187 0.0188
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0426 0.0426
Brugia malayi Protein kinase domain containing protein 0.0017 0.0064 0.0066
Brugia malayi hypothetical protein 0.0017 0.0064 0.0066
Brugia malayi Protein kinase c protein 2 0.0027 0.0197 0.0205
Brugia malayi protein C17H12.11 0.0207 0.2658 0.2755
Schistosoma mansoni tyrosine kinase 0.0084 0.0979 0.0979
Echinococcus granulosus epidermal growth factor receptor 0.0151 0.189 0.189
Echinococcus multilocularis Diacylglycerol kinase theta 0.0026 0.0187 0.0187
Schistosoma mansoni protein kinase C mu 0.0027 0.0197 0.0197
Onchocerca volvulus 0.0017 0.0064 0.0229
Schistosoma mansoni nck2/grb4 0.0019 0.0096 0.0096
Echinococcus multilocularis epidermal growth factor receptor 0.0084 0.0979 0.0979
Schistosoma mansoni rac gtpase activating protein 0.0026 0.0187 0.0187
Echinococcus granulosus TGF beta receptor type 1 0.0335 0.4401 0.4401
Echinococcus multilocularis protein kinase c epsilon type 0.0027 0.0197 0.0197
Brugia malayi Protein kinase domain containing protein 0.0017 0.0064 0.0066
Echinococcus granulosus NCK adaptor protein 0.0019 0.0096 0.0096
Brugia malayi RhoGAP domain containing protein 0.0026 0.0187 0.0193
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0026 0.0193 0.0193
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0018 0.0077 0.008
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0425 0.5619 0.5674
Brugia malayi protein-tyrosine kinase 0.0017 0.0064 0.0066
Loa Loa (eye worm) hypothetical protein 0.0027 0.0205 0.0207
Echinococcus multilocularis epidermal growth factor receptor 0.0151 0.189 0.189
Echinococcus granulosus Rac GTPase activating protein 1 0.0026 0.0187 0.0187
Brugia malayi diacylglycerol kinase 0.0026 0.0187 0.0193
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0027 0.0197 0.0197
Loa Loa (eye worm) TK protein kinase 0.0017 0.0064 0.0065
Brugia malayi N-terminal motif family protein 0.0218 0.2803 0.2906
Entamoeba histolytica hypothetical protein 0.0043 0.0426 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0026 0.0193 0.0193
Loa Loa (eye worm) raf kinase 0.0739 0.9902 1
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0018 0.008 0.008
Echinococcus granulosus protein kinase 0.012 0.1463 0.1463
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0017 0.0064 0.0064
Onchocerca volvulus 0.0017 0.0064 0.0229
Schistosoma mansoni protein kinase 0.012 0.1463 0.1463
Echinococcus multilocularis tyrosine protein kinase Srms 0.0017 0.0064 0.0064
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0053 0.055 0.055
Schistosoma mansoni tyrosine kinase 0.0077 0.0881 0.0881
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0426 0.0426
Schistosoma mansoni unc-13 (munc13) 0.0026 0.0187 0.0187
Echinococcus granulosus TGF-beta receptor type-1 0.0335 0.4401 0.4401
Schistosoma mansoni tyrosine kinase 0.0146 0.1816 0.1816
Entamoeba histolytica hypothetical protein 0.0043 0.0426 1
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0027 0.0197 0.0205
Echinococcus multilocularis N chimaerin 0.0036 0.0319 0.0319
Onchocerca volvulus 0.0017 0.0064 0.0229
Loa Loa (eye worm) hypothetical protein 0.0026 0.0187 0.0188
Brugia malayi Ras association domain family 1 isoform A 0.0026 0.0187 0.0193
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0026 0.0193 0.0193
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0197 0.0197
Brugia malayi C1-like domain containing protein 0.0027 0.0197 0.0205
Toxoplasma gondii diacylglycerol kinase, putative 0.0026 0.0187 0.5
Brugia malayi hypothetical protein 0.0026 0.0181 0.0188
Echinococcus granulosus Diacylglycerol kinase theta 0.0026 0.0187 0.0187
Schistosoma mansoni tyrosine kinase 0.0026 0.0193 0.0193
Schistosoma mansoni vav2 0.0037 0.0337 0.0337
Loa Loa (eye worm) TK/EGFR protein kinase 0.0151 0.189 0.1909
Brugia malayi Pleckstrin Homology Domain 0.0027 0.0205 0.0212
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0078
Brugia malayi Protein kinase domain containing protein 0.0027 0.0197 0.0205
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0018 0.008 0.0081
Echinococcus granulosus tyrosine protein kinase Fyn 0.0026 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0026 0.0187 0.0188
Loa Loa (eye worm) hypothetical protein 0.0026 0.0187 0.0188
Schistosoma mansoni protein kinase 0.0158 0.1986 0.1986
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0027 0.0197 0.0199
Echinococcus multilocularis raf serine:threonine protein kinase 0.0746 1 1
Brugia malayi Protein kinase domain containing protein 0.0053 0.055 0.057
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0026 0.0187 0.0188
Schistosoma mansoni adapter molecule crk 0.0019 0.0096 0.0096
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0017 0.0064 0.0064
Brugia malayi hypothetical protein 0.0018 0.0077 0.008
Onchocerca volvulus 0.0027 0.0205 0.073
Loa Loa (eye worm) RasGEF domain-containing protein 0.0028 0.0222 0.0224
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0036 0.0319 0.0319
Brugia malayi activin receptor:ISOTYPE=IIA. 0.0113 0.1376 0.1426
Echinococcus granulosus myotubularin protein 13 0.0027 0.0205 0.0205
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0027 0.0197 0.0197
Brugia malayi Variant SH3 domain containing protein 0.0036 0.0319 0.0331
Loa Loa (eye worm) SRC-1 0.0026 0.0193 0.0195
Loa Loa (eye worm) hypothetical protein 0.0218 0.2803 0.2831
Schistosoma mansoni protein kinase 0.012 0.1463 0.1463
Loa Loa (eye worm) TK/INSR protein kinase 0.0053 0.055 0.0555
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0061 0.0061
Schistosoma mansoni diacylglycerol kinase theta 0.0026 0.0187 0.0187
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0218 0.2803 1
Brugia malayi RhoGEF domain containing protein 0.0026 0.0187 0.0193
Schistosoma mansoni hypothetical protein 0.0026 0.0187 0.0187
Echinococcus granulosus protein kinase c iota type 0.0027 0.0197 0.0197
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0017 0.0064 0.0064
Echinococcus multilocularis tyrosine kinase 0.0017 0.0064 0.0064
Echinococcus granulosus aryl hydrocarbon receptor 0.0026 0.0185 0.0185
Echinococcus multilocularis insulin receptor 0.0053 0.055 0.055
Loa Loa (eye worm) TK/ABL protein kinase 0.0017 0.0064 0.0065
Echinococcus multilocularis aryl hydrocarbon receptor 0.0026 0.0185 0.0185
Brugia malayi hypothetical protein 0.0018 0.008 0.0083
Loa Loa (eye worm) hypothetical protein 0.0026 0.0187 0.0188
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0064 0.0065
Schistosoma mansoni atypical protein kinase C 0.0027 0.0197 0.0197
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0064 0.0065
Schistosoma mansoni tyrosine kinase 0.0077 0.0881 0.0881
Echinococcus granulosus tyrosine protein kinase Lyn 0.0027 0.0204 0.0204
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0027 0.0197 0.0199
Brugia malayi bone morphogenetic protein type 1 receptor 0.0342 0.4488 0.4652
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0053 0.055 0.055
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0197 0.0197
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0064 0.0065
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0017 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0026 0.0187 0.0188
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0208 0.2669 0.2695
Echinococcus multilocularis 0.0045 0.0443 0.0443
Entamoeba histolytica hypothetical protein 0.0043 0.0426 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0096 0.0097
Loa Loa (eye worm) hypothetical protein 0.0207 0.2658 0.2684
Echinococcus multilocularis NCK adaptor protein 0.0019 0.0096 0.0096
Onchocerca volvulus 0.0026 0.0187 0.0666
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0026 0.0193 0.0193
Schistosoma mansoni diacylglycerol kinase theta 0.0026 0.0187 0.0187
Brugia malayi Sex muscle abnormal protein 5 0.0019 0.0096 0.0099
Schistosoma mansoni growth factor receptor-bound protein 0.0019 0.0096 0.0096
Brugia malayi SRC-1 0.0026 0.0193 0.02
Loa Loa (eye worm) hypothetical protein 0.0018 0.0077 0.0078
Echinococcus granulosus tyrosine protein kinase Blk 0.0017 0.0064 0.0064
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0197 0.0197
Schistosoma mansoni hypothetical protein 0.0043 0.0426 0.0426
Schistosoma mansoni serine/threonine protein kinase 0.0027 0.0197 0.0197
Brugia malayi Tyrosine-protein kinase abl-1 0.0026 0.0193 0.02
Echinococcus granulosus c src tyrosine kinase 0.0026 0.0193 0.0193
Loa Loa (eye worm) TK/FER protein kinase 0.0017 0.0064 0.0065
Brugia malayi protein kinase C II. 0.0027 0.0197 0.0205
Loa Loa (eye worm) hypothetical protein 0.0026 0.0187 0.0188
Echinococcus multilocularis tyrosine protein kinase Abl 0.0026 0.0193 0.0193
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0026 0.0193 0.0193
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0026 0.0193 0.0193

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 63.0957 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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