Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Beta tubulin | 0.0053 | 0.3103 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0021 | 0.0672 | 0.2166 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0021 | 0.0672 | 0.0672 |
Echinococcus multilocularis | beta tubulin | 0.0053 | 0.3103 | 1 |
Leishmania major | beta tubulin | 0.0053 | 0.3103 | 1 |
Trypanosoma brucei | beta tubulin | 0.0021 | 0.0672 | 0.2166 |
Leishmania major | beta tubulin | 0.0053 | 0.3103 | 1 |
Toxoplasma gondii | beta tubulin | 0.0053 | 0.3103 | 1 |
Trypanosoma brucei | beta tubulin | 0.0053 | 0.3103 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0053 | 0.3103 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2402 | 0.7117 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0021 | 0.0672 | 0.2166 |
Trypanosoma brucei | alpha tubulin | 0.0021 | 0.0672 | 0.2166 |
Plasmodium vivax | tubulin beta chain, putative | 0.0053 | 0.3103 | 1 |
Leishmania major | beta tubulin | 0.0053 | 0.3103 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0053 | 0.3103 | 0.3103 |
Trypanosoma brucei | tubulin gamma chain | 0.0021 | 0.0672 | 0.2166 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0021 | 0.0672 | 0.0672 |
Leishmania major | beta tubulin | 0.0053 | 0.3103 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0053 | 0.3103 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0053 | 0.3103 | 0.3103 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0021 | 0.0672 | 0.0672 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0053 | 0.3103 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0053 | 0.3103 | 1 |
Giardia lamblia | Beta tubulin | 0.0053 | 0.3103 | 1 |
Brugia malayi | Tubulin alpha chain | 0.0021 | 0.0672 | 0.0672 |
Echinococcus multilocularis | tubulin subunit beta | 0.0053 | 0.3103 | 1 |
Leishmania major | beta tubulin | 0.0053 | 0.3103 | 1 |
Brugia malayi | tubulin alpha-2 chain | 0.0021 | 0.0672 | 0.0672 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0053 | 0.3103 | 0.3103 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0021 | 0.0672 | 0.2166 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2402 | 0.7117 |
Trypanosoma brucei | alpha tubulin | 0.0021 | 0.0672 | 0.2166 |
Loa Loa (eye worm) | BEN-1 protein | 0.0053 | 0.3103 | 0.3103 |
Loa Loa (eye worm) | alpha-tubulin | 0.0021 | 0.0672 | 0.0672 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0021 | 0.0672 | 0.2166 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.2402 | 0.2402 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0021 | 0.0672 | 0.2166 |
Leishmania major | beta tubulin | 0.0053 | 0.3103 | 1 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0053 | 0.3103 | 1 |
Leishmania major | beta tubulin | 0.0053 | 0.3103 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0053 | 0.3103 | 1 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0021 | 0.0672 | 0.2166 |
Brugia malayi | Tubulin alpha-2 chain | 0.0021 | 0.0672 | 0.0672 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0053 | 0.3103 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0021 | 0.0672 | 0.2166 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0053 | 0.3103 | 1 |
Brugia malayi | alpha-tubulin | 0.0021 | 0.0672 | 0.0672 |
Echinococcus granulosus | tubulin subunit beta | 0.0053 | 0.3103 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2402 | 0.7117 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0021 | 0.0672 | 0.0672 |
Leishmania major | beta tubulin | 0.0053 | 0.3103 | 1 |
Trypanosoma brucei | epsilon tubulin | 0.0021 | 0.0672 | 0.2166 |
Leishmania major | beta tubulin | 0.0053 | 0.3103 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0021 | 0.0672 | 0.2166 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0672 | 0.0672 |
Plasmodium falciparum | tubulin beta chain | 0.0053 | 0.3103 | 1 |
Trypanosoma brucei | epsilon tubulin | 0.0021 | 0.0672 | 0.2166 |
Trypanosoma brucei | epsilon tubulin | 0.0021 | 0.0672 | 0.2166 |
Schistosoma mansoni | tubulin subunit beta | 0.0053 | 0.3103 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0053 | 0.3103 | 1 |
Trypanosoma brucei | alpha tubulin | 0.0021 | 0.0672 | 0.2166 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2402 | 0.7117 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0053 | 0.3103 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0053 | 0.3103 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0053 | 0.3103 | 1 |
Leishmania major | beta tubulin | 0.0053 | 0.3103 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0053 | 0.3103 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0053 | 0.3103 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0021 | 0.0672 | 0.2166 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0053 | 0.3103 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0053 | 0.3103 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0053 | 0.3103 | 1 |
Leishmania major | beta tubulin | 0.0053 | 0.3103 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0053 | 0.3103 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0053 | 0.3103 | 1 |
Brugia malayi | Tubulin beta-1 chain | 0.0053 | 0.3103 | 0.3103 |
Trypanosoma brucei | beta tubulin | 0.0053 | 0.3103 | 1 |
Loa Loa (eye worm) | alpha-tubulin | 0.0021 | 0.0672 | 0.0672 |
Trypanosoma brucei | alpha tubulin | 0.0021 | 0.0672 | 0.2166 |
Leishmania major | beta tubulin | 0.0053 | 0.3103 | 1 |
Leishmania major | beta tubulin | 0.0053 | 0.3103 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2402 | 0.7117 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0021 | 0.0672 | 0.2166 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0053 | 0.3103 | 1 |
Brugia malayi | tubulin alpha chain - mouse | 0.0021 | 0.0672 | 0.0672 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0053 | 0.3103 | 0.3103 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0053 | 0.3103 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0053 | 0.3103 | 1 |
Trypanosoma brucei | beta tubulin | 0.0053 | 0.3103 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0053 | 0.3103 | 1 |
Leishmania major | beta tubulin | 0.0053 | 0.3103 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0021 | 0.0672 | 0.2166 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0021 | 0.0672 | 0.2166 |
Toxoplasma gondii | beta-tubulin, putative | 0.0053 | 0.3103 | 1 |
Leishmania major | beta tubulin | 0.0053 | 0.3103 | 1 |
Echinococcus granulosus | beta tubulin | 0.0053 | 0.3103 | 1 |
Giardia lamblia | Beta tubulin | 0.0053 | 0.3103 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0053 | 0.3103 | 0.3103 |
Leishmania major | beta tubulin | 0.0053 | 0.3103 | 1 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0053 | 0.3103 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0053 | 0.3103 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0053 | 0.3103 | 0.3103 |
Loa Loa (eye worm) | beta-tubulin | 0.0053 | 0.3103 | 0.3103 |
Echinococcus granulosus | beta tubulin | 0.0053 | 0.3103 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0053 | 0.3103 | 1 |
Brugia malayi | Tubulin alpha-2 chain | 0.0021 | 0.0672 | 0.0672 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2402 | 0.7117 |
Echinococcus multilocularis | beta tubulin | 0.0053 | 0.3103 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0053 | 0.3103 | 1 |
Trypanosoma brucei | beta tubulin | 0.0053 | 0.3103 | 1 |
Leishmania major | beta tubulin | 0.0053 | 0.3103 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2402 | 0.7117 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2402 | 0.7117 |
Leishmania major | beta tubulin | 0.0053 | 0.3103 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0053 | 0.3103 | 1 |
Brugia malayi | Tubulin gamma chain | 0.0021 | 0.0672 | 0.0672 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0053 | 0.3103 | 1 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0058 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.