Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | multiple endocrine neoplasia I | No references | |
Homo sapiens | lysine (K)-specific methyltransferase 2A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0024 | 0.0252 | 0.6156 |
Brugia malayi | Cytochrome P450 family protein | 0.0024 | 0.0252 | 0.6156 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0011 | 0.0081 | 0.1327 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.0395 | 0.4978 | 1 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0009 | 0.0056 | 0.0035 |
Trypanosoma brucei | lanosterol synthase | 0.0594 | 0.7515 | 1 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0035 | 0.0388 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0035 | 0.0388 | 0.0608 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0024 | 0.0252 | 0.0291 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0056 | 0.0074 |
Echinococcus multilocularis | cpg binding protein | 0.0037 | 0.0414 | 0.0381 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0046 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0083 | 0.0079 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0046 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0046 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0007 | 0.0034 | 0.004 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0024 | 0.0252 | 0.6156 |
Onchocerca volvulus | 0.0035 | 0.0388 | 0.5 | |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0074 | 0.0884 | 0.1403 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0046 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0024 | 0.0252 | 0.6156 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0046 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0046 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0024 | 0.0252 | 0.0291 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0024 | 0.0252 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0046 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0046 | 1 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0009 | 0.0056 | 0.0022 |
Echinococcus granulosus | cpg binding protein | 0.0037 | 0.0414 | 0.0611 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0046 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0035 | 0.0388 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0046 | 1 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0494 | 0.6243 | 0.6231 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0056 | 0.0035 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0046 | 1 |
Echinococcus granulosus | dnaJ subfamily B | 0.0494 | 0.6243 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0046 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0046 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0046 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0007 | 0.0034 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0007 | 0.0034 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0046 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0414 | 0.0648 |
Schistosoma mansoni | hypothetical protein | 0.0494 | 0.6243 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0066 | 0.0784 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0046 | 1 |
Leishmania major | lanosterol synthase, putative | 0.0594 | 0.7515 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0046 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0164 | 0.367 |
Schistosoma mansoni | hypothetical protein | 0.0007 | 0.0034 | 0.004 |
Trypanosoma brucei | cytochrome P450, putative | 0.0024 | 0.0252 | 0.0291 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0056 | 0.0022 |
Loa Loa (eye worm) | histone methyltransferase | 0.0011 | 0.0083 | 0.1377 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0046 | 1 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0594 | 0.7515 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0037 | 0.0414 | 0.0648 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0024 | 0.0252 | 0.0291 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0594 | 0.7515 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0024 | 0.0252 | 0.6156 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.0083 | 0.0049 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.7865 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 63.0957 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.