Detailed information for compound 1457804

Basic information

Technical information
  • TDR Targets ID: 1457804
  • Name: N-[5-(1-methyl-2-oxoindol-3-ylidene)-4-oxo-2- sulfanylidene-1,3-thiazolidin-3-yl]pyridine-3 -carboxamide
  • MW: 396.443 | Formula: C18H12N4O3S2
  • H donors: 1 H acceptors: 4 LogP: 1.96 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccnc1)NN1C(=S)S/C(=C/2\C(=O)N(c3c2cccc3)C)/C1=O
  • InChi: 1S/C18H12N4O3S2/c1-21-12-7-3-2-6-11(12)13(16(21)24)14-17(25)22(18(26)27-14)20-15(23)10-5-4-8-19-9-10/h2-9H,1H3,(H,20,23)/b14-13-
  • InChiKey: SUDSASVRROTXIY-YPKPFQOOSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(5Z)-5-(1-methyl-2-oxoindol-3-ylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]pyridine-3-carboxamide
  • N-[5-(1-methyl-2-oxo-indolin-3-ylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]pyridine-3-carboxamide
  • N-[(5Z)-5-(1-methyl-2-oxo-indolin-3-ylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]pyridine-3-carboxamide
  • N-[(5Z)-5-(1-methyl-2-oxo-3-indolinylidene)-4-oxo-2-thioxo-3-thiazolidinyl]-3-pyridinecarboxamide
  • N-[5-(1-methyl-2-oxo-3-indolinylidene)-4-oxo-2-thioxo-3-thiazolidinyl]-3-pyridinecarboxamide
  • N-[(5Z)-4-keto-5-(2-keto-1-methyl-indolin-3-ylidene)-2-thioxo-thiazolidin-3-yl]nicotinamide
  • N-[4-keto-5-(2-keto-1-methyl-indolin-3-ylidene)-2-thioxo-thiazolidin-3-yl]nicotinamide
  • N-[5-(1-methyl-2-oxo-indol-3-ylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]pyridine-3-carboxamide
  • N-[(5Z)-5-(1-methyl-2-oxo-indol-3-ylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]pyridine-3-carboxamide
  • Oprea1_253251
  • BIM-0030836.P001
  • A2195/0092330
  • ZINC01090168
  • BAS 00909192
  • CBMicro_030962

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens EYA transcriptional coactivator and phosphatase 2 Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni eyes absent homolog Get druggable targets OG5_129664 All targets in OG5_129664
Schistosoma japonicum ko:K01104 protein-tyrosine phosphatase [EC3.1.3.48], putative Get druggable targets OG5_129664 All targets in OG5_129664
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi hypothetical protein Get druggable targets OG5_129664 All targets in OG5_129664
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0106 0.204 1
Toxoplasma gondii thioredoxin reductase 0.0046 0.0672 0.6025
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.7593 1
Plasmodium falciparum ornithine aminotransferase 0.0065 0.1116 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7593 0.7593
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0065 0.1116 0.1116
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0065 0.1116 0.1116
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.3527 0.2714
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.199 0.199
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0065 0.1116 0.1116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7593 0.7593
Schistosoma mansoni eyes absent homolog 0.0106 0.204 0.6943
Mycobacterium tuberculosis Probable reductase 0.0104 0.199 0.199
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7593 0.7593
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0065 0.1116 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1366 0.465
Plasmodium vivax glutathione reductase, putative 0.0046 0.0672 0.6025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7593 0.7593
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1366 0.465
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.199 0.199
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.3527 0.3527
Mycobacterium ulcerans L-lysine aminotransferase 0.0065 0.1116 0.1116
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1366 0.6697
Echinococcus multilocularis ornithine aminotransferase 0.0065 0.1116 0.8167
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0065 0.1116 0.547
Brugia malayi Thioredoxin reductase 0.0046 0.0672 0.3295
Mycobacterium ulcerans acetylornithine aminotransferase 0.0065 0.1116 0.1116
Plasmodium falciparum thioredoxin reductase 0.0046 0.0672 0.6025
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0065 0.1116 1
Mycobacterium ulcerans hypothetical protein 0.046 1 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.2252 0.1279
Leishmania major trypanothione reductase 0.0046 0.0672 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.199 0.0984
Loa Loa (eye worm) hypothetical protein 0.0106 0.204 1
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.7593 1
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1366 0.465
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.199 0.199
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0672 0.0672
Plasmodium falciparum glutathione reductase 0.0046 0.0672 0.6025
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1366 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.3527 0.3527
Echinococcus granulosus ornithine aminotransferase 0.0065 0.1116 0.8167
Brugia malayi hypothetical protein 0.0106 0.204 1
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0065 0.1116 0.1116
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0686 0.5021
Brugia malayi TAR-binding protein 0.0076 0.1366 0.6697
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0065 0.1116 0.1116
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1366 0.5074
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0672 1
Echinococcus granulosus Aminotransferase class III 0.0065 0.1116 0.8167
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.046 1 1
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0065 0.1116 1
Echinococcus multilocularis ornithine aminotransferase 0.0065 0.1116 0.8167
Brugia malayi glutathione reductase 0.0046 0.0672 0.3295
Mycobacterium tuberculosis Probable aminotransferase 0.046 1 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.2252 0.2252
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0065 0.1116 0.1116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7593 0.7593
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.046 1 1
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0065 0.1116 0.3798
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1366 0.465
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0065 0.1116 0.1116
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.7593 0.5
Echinococcus granulosus tar DNA binding protein 0.0076 0.1366 1
Loa Loa (eye worm) RNA binding protein 0.0076 0.1366 0.5074
Brugia malayi RNA binding protein 0.0076 0.1366 0.6697
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1366 0.5074
Plasmodium vivax ornithine aminotransferase, putative 0.0065 0.1116 1
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0672 0.6025
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1366 0.465
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.2252 0.2252
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.2252 0.2252
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.199 0.199
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.7593 0.5
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0686 0.5021
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0065 0.1116 0.1116
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7593 0.7593
Trypanosoma brucei trypanothione reductase 0.0046 0.0672 1
Echinococcus multilocularis Aminotransferase class III 0.0065 0.1116 0.8167
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.046 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7593 0.7593
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.199 0.199
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.7593 0.7593

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.7783 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 2.5119 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 9.53 uM PubChem BioAssay. qHTS for Inhibitors of the Phosphatase Activity of Eya2: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Giardia lamblia growth inhibition. (Class of assay: confirmatory) [Related pubchem assays: 2451, 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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