TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 347.367 | Formula: C20H17N3O3
H donors: 1 H acceptors: 3 LogP: 1.93 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=c1[nH]c(=O)n(cc1C)C/C=C/Cn1c2cccc3c2c(c1=O)ccc3
InChi: 1S/C20H17N3O3/c1-13-12-22(20(26)21-18(13)24)10-2-3-11-23-16-9-5-7-14-6-4-8-15(17(14)16)19(23)25/h2-9,12H,10-11H2,1H3,(H,21,24,26)/b3-2+
InChiKey: QZCGIHOVXKABID-NSCUHMNNSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mycobacterium tuberculosis	Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK)		References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Onchocerca volvulus	Putative thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Trypanosoma cruzi	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Schistosoma mansoni	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Giardia lamblia	CDC8	Get druggable targets OG5_126920	All targets in OG5_126920
Plasmodium knowlesi	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Leishmania major	thymidylate kinase-like protein	Get druggable targets OG5_126920	All targets in OG5_126920
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_126920	All targets in OG5_126920
Wolbachia endosymbiont of Brugia malayi	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Echinococcus multilocularis	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Loa Loa (eye worm)	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Mycobacterium leprae	probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK)	Get druggable targets OG5_126920	All targets in OG5_126920
Mycobacterium tuberculosis	Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK)	Get druggable targets OG5_126920	All targets in OG5_126920
Trypanosoma brucei	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Mycobacterium ulcerans	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Schistosoma japonicum	Thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Trypanosoma brucei	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Schistosoma japonicum	ko:K00943 dTMP kinase [EC2.7.4.9], putative	Get druggable targets OG5_126920	All targets in OG5_126920
Trypanosoma congolense	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Echinococcus granulosus	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Trypanosoma brucei gambiense	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Brugia malayi	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Cryptosporidium hominis	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Plasmodium berghei	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Candida albicans	Thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Trichomonas vaginalis	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Chlamydia trachomatis	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Leishmania mexicana	thymidylate kinase-like protein	Get druggable targets OG5_126920	All targets in OG5_126920
Schistosoma mansoni	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Babesia bovis	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Entamoeba histolytica	Thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Leishmania braziliensis	thymidylate kinase-like protein	Get druggable targets OG5_126920	All targets in OG5_126920
Treponema pallidum	thymidylate kinase (tmk)	Get druggable targets OG5_126920	All targets in OG5_126920
Leishmania infantum	thymidylate kinase-like protein	Get druggable targets OG5_126920	All targets in OG5_126920
Leishmania donovani	thymidylate kinase-like protein	Get druggable targets OG5_126920	All targets in OG5_126920
Theileria parva	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Candida albicans	Thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Neospora caninum	Thymidylate kinase, related	Get druggable targets OG5_126920	All targets in OG5_126920
Trypanosoma congolense	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Plasmodium yoelii	Thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Toxoplasma gondii	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Trichomonas vaginalis	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Plasmodium falciparum	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Cryptosporidium parvum	thymidylate kinase	Get druggable targets OG5_126920	All targets in OG5_126920
Plasmodium vivax	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920
Trypanosoma cruzi	thymidylate kinase, putative	Get druggable targets OG5_126920	All targets in OG5_126920

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0812	0.0835
Schistosoma mansoni	hypothetical protein	0.0018	0.028	0.028
Echinococcus granulosus	L aminoadipate semialdehyde	0.0081	0.1891	0.1891
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.028	0.028
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.115	0.115
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.028	0.028
Schistosoma mansoni	cpg binding protein	0.003	0.0578	0.0578
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0812	0.0838
Loa Loa (eye worm)	inositol-1	0.0036	0.0742	0.0759
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.0034	0.0689	0.1886
Trypanosoma brucei	hypothetical protein, conserved	0.0023	0.0404	0.0752
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0051	0.1121	0.3606
Mycobacterium leprae	probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK)	0.0087	0.2031	1
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0023	0.0404	0.104
Onchocerca volvulus		0.0371	0.9244	1
Echinococcus multilocularis	thymidylate kinase	0.0087	0.2031	0.2031
Plasmodium falciparum	thymidylate kinase	0.0087	0.2031	1
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0742	0.2897
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.0216	0.0216
Echinococcus multilocularis	geminin	0.0194	0.4742	0.4742
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.0216	0.0216
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0742	0.0381
Schistosoma mansoni	loxhd1	0.0019	0.0313	0.0313
Brugia malayi	Low molecular weight phosphotyrosine protein phosphatase containing protein	0.0371	0.9244	1
Schistosoma mansoni	hypothetical protein	0.0018	0.028	0.028
Loa Loa (eye worm)	hypothetical protein	0.0018	0.028	0.0257
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.0313	0.0537
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.1121	0.0446
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.0216	0.0187
Trypanosoma cruzi	thymidylate kinase, putative	0.0087	0.2031	0.7229
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0742	0.2094
Trypanosoma brucei	protein kinase, putative	0.0051	0.1121	0.3606
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.0034	0.0689	0.1886
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0371	0.9244	1
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.1121	0.0446
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0051	0.1121	0.1171
Treponema pallidum	thymidylate kinase (tmk)	0.0087	0.2031	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.115	0.115
Echinococcus multilocularis	dnaJ subfamily B	0.0401	1	1
Echinococcus multilocularis	cpg binding protein	0.003	0.0578	0.0578
Loa Loa (eye worm)	hypothetical protein	0.012	0.2871	0.3073
Mycobacterium ulcerans	thymidylate kinase	0.0087	0.2031	0.184
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0742	0.0742
Schistosoma mansoni	hypothetical protein	0.0087	0.2031	0.2031
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.1176	0.5293
Brugia malayi	MAP kinase sur-1	0.0051	0.1121	0.1174
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.115	0.115
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.115	0.115
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0057	0.127	0.1335
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.115	0.1203
Trichomonas vaginalis	thymidylate kinase, putative	0.0087	0.2031	0.1516
Loa Loa (eye worm)	phosphotyrosine protein phosphatase	0.0371	0.9244	1
Trypanosoma brucei	thymidylate kinase, putative	0.0087	0.2031	0.7229
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.0645	0.0702
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0313	0.0313
Echinococcus multilocularis	GPCR, family 2	0.0018	0.028	0.028
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.028	0.0257
Onchocerca volvulus		0.0081	0.1891	0.1767
Trypanosoma brucei	low molecular weight protein tyrosine phosphatase, putative	0.0114	0.2727	1
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0051	0.1121	0.3606
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.1121	0.3606
Schistosoma mansoni	hypothetical protein	0.0019	0.0313	0.0313
Echinococcus granulosus	cpg binding protein	0.003	0.0578	0.0578
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.0313	0.0313
Mycobacterium tuberculosis	Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK)	0.0087	0.2031	0.2964
Schistosoma mansoni	thymidylate kinase	0.0087	0.2031	0.2031
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0114	0.2727	0.2335
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0371	0.9244	1
Schistosoma mansoni	lipoxygenase	0.0081	0.1874	0.1874
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.1121	0.3606
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0081	0.1891	0.1891
Schistosoma mansoni	cpg binding protein	0.003	0.0578	0.0578
Schistosoma mansoni	hypothetical protein	0.0018	0.028	0.028
Echinococcus granulosus	mitogen activated protein kinase	0.0051	0.1121	0.1121
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0742	0.2094
Schistosoma mansoni	polycystin 1-related	0.0019	0.0313	0.0313
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0051	0.1121	0.1121
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0371	0.9244	1
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.0313	0.0537
Brugia malayi	thymidylate kinase	0.0087	0.2031	0.2162
Trypanosoma cruzi	hypothetical protein, conserved	0.0114	0.2727	1
Mycobacterium ulcerans	phosphotyrosine protein phosphatase PtpA	0.0371	0.9244	1
Wolbachia endosymbiont of Brugia malayi	thymidylate kinase	0.0087	0.2031	1
Toxoplasma gondii	thymidylate kinase	0.0087	0.2031	1
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.1121	0.0446
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0742	0.0742
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0216	0.0216
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.115	0.115
Giardia lamblia	Low molecular weight protein-tyrosine-phosphatase	0.0371	0.9244	1
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0114	0.2727	0.2335
Schistosoma mansoni	hypothetical protein	0.0018	0.028	0.028
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.028	0.028
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.1121	0.1121
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0404	0.104
Plasmodium vivax	thymidylate kinase, putative	0.0087	0.2031	1
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0116	0.2757	0.2757
Echinococcus multilocularis	mitogen activated protein kinase	0.0051	0.1121	0.1121
Trichomonas vaginalis	low molecular weight protein tyrosine phosphatase, putative	0.0371	0.9244	1
Brugia malayi	Doublecortin family protein	0.0019	0.0313	0.0296
Entamoeba histolytica	Thymidylate kinase, putative	0.0087	0.2031	0.184
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.0216	0.0216
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0742	0.2094
Brugia malayi	hypothetical protein	0.012	0.2871	0.3075
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0742	0.2073
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0081	0.1891	0.1891
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.028	0.026
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0313	0.0293
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0742	0.0742
Onchocerca volvulus	Huntingtin homolog	0.012	0.2871	0.2864
Schistosoma mansoni	cpg binding protein	0.0028	0.0537	0.0537
Loa Loa (eye worm)	thymidylate kinase	0.0087	0.2031	0.216
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0051	0.1121	0.3606
Schistosoma mansoni	hypothetical protein	0.0194	0.4742	0.4742
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0742	0.2094
Leishmania major	phosphopantetheinyl transferase-like protein	0.0023	0.0404	0.0752
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.0313	0.0293
Leishmania major	thymidylate kinase-like protein	0.0087	0.2031	0.7229
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0313	0.0313
Brugia malayi	Inositol-1	0.0036	0.0742	0.0761
Trypanosoma cruzi	hypothetical protein, conserved	0.0114	0.2727	1
Onchocerca volvulus	Huntingtin homolog	0.012	0.2871	0.2864
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0537	0.0539
Schistosoma mansoni	hypothetical protein	0.0039	0.0812	0.0812
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0371	0.9244	1
Chlamydia trachomatis	thymidylate kinase	0.0087	0.2031	1
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0371	0.9244	1
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.0313	0.0313
Schistosoma mansoni	hypothetical protein	0.0401	1	1
Trypanosoma brucei	thymidylate kinase, putative	0.0087	0.2031	0.7229
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0371	0.9244	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0044	0.0044
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.0645	0.1481
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0537	0.0536
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0023	0.0404	0.104
Onchocerca volvulus		0.0028	0.0537	0.0251
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.115	0.115
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0023	0.0404	0.104
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.1121	0.0446
Schistosoma mansoni	rab6-interacting	0.0019	0.0313	0.0313
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0742	0.0381
Schistosoma mansoni	hypothetical protein	0.0194	0.4742	0.4742
Echinococcus granulosus	thymidylate kinase	0.0087	0.2031	0.2031
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0313	0.0293
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0044	0.0044
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.0216	0.019
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.1338	0.1338
Leishmania major	hypothetical protein, conserved	0.0034	0.0689	0.1886
Brugia malayi	isocitrate dehydrogenase	0.0015	0.0216	0.019
Echinococcus multilocularis	RUN	0.0019	0.0313	0.0313
Schistosoma mansoni	thymidylate kinase	0.0087	0.2031	0.2031
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.115	0.1206
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.028	0.028
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0313	0.0313
Leishmania major	hypothetical protein, conserved	0.0114	0.2727	1
Trichomonas vaginalis	thymidylate kinase, putative	0.0087	0.2031	0.1516
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0051	0.1121	0.3606
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0216	0.0216
Trichomonas vaginalis	low molecular weight protein-tyrosine-phosphatase, putative	0.0371	0.9244	1
Echinococcus granulosus	geminin	0.0194	0.4742	0.4742
Echinococcus granulosus	mitogen activated protein kinase 3	0.0051	0.1121	0.1121
Onchocerca volvulus	Putative thymidylate kinase	0.0087	0.2031	0.1923
Brugia malayi	hypothetical protein	0.0019	0.0313	0.0296
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0051	0.1121	0.3606
Trypanosoma cruzi	thymidylate kinase, putative	0.0087	0.2031	0.7229
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0051	0.1121	0.4988
Echinococcus granulosus	RUN	0.0019	0.0313	0.0313
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0081	0.1891	0.2011
Loa Loa (eye worm)	hypothetical protein	0.012	0.2871	0.3073
Loa Loa (eye worm)	hypothetical protein	0.0081	0.1891	0.2008
Brugia malayi	hypothetical protein	0.0019	0.0313	0.0296
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.028	0.026
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0023	0.0404	0.0308
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0116	0.2757	0.2757
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0057	0.127	0.1335
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0313	0.0313
Giardia lamblia	CDC8	0.0087	0.2031	0.112
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0057	0.127	0.1333
Loa Loa (eye worm)	hypothetical protein	0.0057	0.127	0.1333
Schistosoma mansoni	lipoxygenase	0.0116	0.2757	0.2757
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.0216	0.0216
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0742	0.0742
Mycobacterium tuberculosis	Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase)	0.0257	0.6339	1
Schistosoma mansoni	rab6-interacting	0.0019	0.0313	0.0313
Echinococcus granulosus	GPCR family 2	0.0018	0.028	0.028
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.0216	0.0216
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.115	0.115

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.42 uM	Inhibition of Mycobacterium tuberculosis Thymidine monophosphate kinase by spectrophotometry	ChEMBL.	20951473

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1632625

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1462144