Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Nischarin | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | nischarin | Get druggable targets OG5_133208 | All targets in OG5_133208 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_133208 | All targets in OG5_133208 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133208 | All targets in OG5_133208 |
Echinococcus granulosus | nischarin | Get druggable targets OG5_133208 | All targets in OG5_133208 |
Onchocerca volvulus | Nischarin homolog | Get druggable targets OG5_133208 | All targets in OG5_133208 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0182 | 0.1895 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0182 | 0.1895 | 0.1895 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0005 | 0.0005 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0182 | 0.1895 | 0.1895 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0182 | 0.1895 | 0.1891 |
Onchocerca volvulus | Nischarin homolog | 0.0166 | 0.1485 | 0.1485 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0503 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.149 | 0.149 |
Mycobacterium tuberculosis | Conserved protein | 0.0182 | 0.1895 | 0.5 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0182 | 0.1895 | 0.1891 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0182 | 0.1895 | 0.1895 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0503 | 1 | 1 |
Schistosoma mansoni | nicalin (M28 family) | 0.0182 | 0.1895 | 0.1895 |
Brugia malayi | nicalin | 0.0182 | 0.1895 | 0.1895 |
Mycobacterium ulcerans | hypothetical protein | 0.0182 | 0.1895 | 0.5 |
Brugia malayi | hypothetical protein | 0.0166 | 0.149 | 0.149 |
Echinococcus multilocularis | nischarin | 0.017 | 0.1586 | 0.1581 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0182 | 0.1895 | 0.1891 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0503 | 1 | 1 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0182 | 0.1895 | 0.1895 |
Toxoplasma gondii | hypothetical protein | 0.0182 | 0.1895 | 0.5 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0503 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.1895 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0503 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1895 | 0.1895 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0182 | 0.1895 | 0.1895 |
Brugia malayi | leucyl aminopeptidase | 0.0182 | 0.1895 | 0.1895 |
Brugia malayi | FXNA | 0.0182 | 0.1895 | 0.1895 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0182 | 0.1895 | 0.1895 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.1895 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1895 | 0.1895 |
Brugia malayi | Peroxidasin | 0.0107 | 0.0005 | 0.0005 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0182 | 0.1895 | 0.5 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0182 | 0.1895 | 0.1895 |
Onchocerca volvulus | 0.0182 | 0.1895 | 0.1895 | |
Leishmania major | glutaminyl cyclase, putative | 0.0182 | 0.1895 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1895 | 0.1895 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0182 | 0.1895 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0182 | 0.1895 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0107 | 0.0005 | 0.0005 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0182 | 0.1895 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1895 | 0.1895 |
Leishmania major | hypothetical protein, conserved | 0.0182 | 0.1895 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0107 | 0.0005 | 0.0005 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0182 | 0.1895 | 0.1891 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0182 | 0.1895 | 0.1891 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0182 | 0.1895 | 0.5 |
Echinococcus granulosus | nischarin | 0.017 | 0.1586 | 0.1581 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0182 | 0.1895 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.1895 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2716 nM | Inhibition of Sprague-Dawley rat imidazoline I1 receptor | ChEMBL. | 21159515 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.