Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0128 | 0.0214 | 0.0629 |
Plasmodium falciparum | 3-oxoacyl-[acyl-carrier-protein] reductase | 0.008 | 0.0115 | 0.048 |
Mycobacterium tuberculosis | Probable reductase | 0.0116 | 0.0188 | 0.0524 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.008 | 0.0115 | 0.1203 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.008 | 0.0115 | 0.0062 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0051 | 0.0054 | 0.3847 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.008 | 0.0115 | 0.0241 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0464 | 0.0906 | 0.9444 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0025 | 0.0257 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.008 | 0.0115 | 0.0241 |
Trichomonas vaginalis | hypothetical protein | 0.1188 | 0.2402 | 0.5 |
Mycobacterium tuberculosis | Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) | 0.008 | 0.0115 | 0.0241 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.008 | 0.0115 | 0.8242 |
Plasmodium falciparum | thioredoxin reductase | 0.0051 | 0.0054 | 0.0224 |
Loa Loa (eye worm) | hypothetical protein | 0.0464 | 0.0906 | 0.9444 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0092 | 0.014 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.008 | 0.0115 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.008 | 0.0115 | 0.8242 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0464 | 0.0906 | 0.9444 |
Plasmodium falciparum | glutathione reductase | 0.0051 | 0.0054 | 0.0224 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.006 | 0.062 |
Echinococcus multilocularis | dual specificity protein phosphatase | 0.0489 | 0.096 | 0.0911 |
Schistosoma mansoni | dihydropteridine reductase | 0.008 | 0.0115 | 0.0351 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.1188 | 0.2402 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.1188 | 0.2402 | 1 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0092 | 0.014 | 1 |
Echinococcus granulosus | geminin | 0.0165 | 0.029 | 0.0238 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.008 | 0.0115 | 0.1203 |
Onchocerca volvulus | 0.0092 | 0.014 | 0.0291 | |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0092 | 0.014 | 0.0099 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0092 | 0.014 | 0.0099 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.008 | 0.0115 | 0.0241 |
Mycobacterium ulcerans | replicative DNA helicase DnaB | 0.1289 | 0.2609 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0051 | 0.0054 | 0.0561 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.487 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0051 | 0.0054 | 0.0224 |
Loa Loa (eye worm) | twinkle helicase | 0.0368 | 0.0709 | 0.7391 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0092 | 0.014 | 0.0099 |
Echinococcus multilocularis | geminin | 0.0165 | 0.029 | 0.0238 |
Onchocerca volvulus | 0.0489 | 0.096 | 1 | |
Loa Loa (eye worm) | dual specificity phosphatase | 0.0489 | 0.096 | 1 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.008 | 0.0115 | 0.8242 |
Schistosoma mansoni | dual specificity protein phosphatase | 0.0489 | 0.096 | 0.3618 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0092 | 0.014 | 0.0337 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.008 | 0.0115 | 0.0241 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0116 | 0.0188 | 0.0524 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.029 | 0.1028 |
Leishmania major | pteridine reductase 1 | 0.0092 | 0.014 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.0025 | 0.0257 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0673 | 0.1338 | 0.1291 |
Brugia malayi | MH2 domain containing protein | 0.0128 | 0.0213 | 0.2223 |
Loa Loa (eye worm) | glutathione reductase | 0.0051 | 0.0054 | 0.0561 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.1188 | 0.2402 | 0.9171 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0128 | 0.0214 | 0.0629 |
Brugia malayi | Dual specificity phosphatase, catalytic domain containing protein | 0.0489 | 0.096 | 1 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.008 | 0.0115 | 0.0062 |
Schistosoma mansoni | hypothetical protein | 0.0464 | 0.0906 | 0.3411 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.1188 | 0.2402 | 1 |
Plasmodium vivax | 3-oxoacyl-[acyl-carrier-protein] reductase, putative | 0.008 | 0.0115 | 0.048 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0673 | 0.1338 | 0.5081 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0051 | 0.0054 | 0.0224 |
Trypanosoma brucei | pteridine reductase 1 | 0.008 | 0.0115 | 0.8242 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.029 | 0.1028 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0673 | 0.1338 | 0.1291 |
Toxoplasma gondii | short chain dehydrogenase family protein, putative | 0.008 | 0.0115 | 0.048 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.008 | 0.0115 | 0.1203 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.008 | 0.0115 | 0.8242 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0128 | 0.0213 | 0.2223 |
Brugia malayi | glutathione reductase | 0.0051 | 0.0054 | 0.0561 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.008 | 0.0115 | 0.0241 |
Schistosoma mansoni | apoptosis regulator bax | 0.0464 | 0.0906 | 0.3411 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0128 | 0.0214 | 0.0629 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0116 | 0.0188 | 0.029 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0115 | 0.1203 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.1289 | 0.2609 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.006 | 0.062 |
Giardia lamblia | Dual specificity phosphatase, catalytic | 0.0489 | 0.096 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.006 | 0.062 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0116 | 0.0188 | 0.0524 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.1188 | 0.2402 | 0.9191 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0116 | 0.0188 | 0.0524 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.008 | 0.0115 | 0.0351 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.1188 | 0.2402 | 0.9171 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.1188 | 0.2402 | 0.9171 |
Plasmodium vivax | glutathione reductase, putative | 0.0051 | 0.0054 | 0.0224 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0116 | 0.0188 | 0.0524 |
Trypanosoma brucei | trypanothione reductase | 0.0051 | 0.0054 | 0.3847 |
Schistosoma mansoni | hypothetical protein | 0.0464 | 0.0906 | 0.3411 |
Brugia malayi | Thioredoxin reductase | 0.0051 | 0.0054 | 0.0561 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.1188 | 0.2402 | 0.9171 |
Leishmania major | oxidoreductase-like protein | 0.0092 | 0.014 | 1 |
Mycobacterium leprae | PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase | 0.1289 | 0.2609 | 1 |
Schistosoma mansoni | Replicative DNA helicase | 0.1289 | 0.2609 | 1 |
Chlamydia trachomatis | replicative DNA helicase | 0.1289 | 0.2609 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0116 | 0.0188 | 0.0524 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.008 | 0.0115 | 0.1203 |
Mycobacterium tuberculosis | Probable dehydrogenase/reductase | 0.008 | 0.0115 | 0.0241 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0464 | 0.0906 | 0.0857 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0092 | 0.014 | 0.0583 |
Loa Loa (eye worm) | oxidoreductase | 0.008 | 0.0115 | 0.1203 |
Leishmania major | trypanothione reductase | 0.0051 | 0.0054 | 0.3847 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0128 | 0.0214 | 0.0397 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.008 | 0.0115 | 0.8242 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.008 | 0.0115 | 0.8242 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0464 | 0.0906 | 0.3411 |
Echinococcus granulosus | dual specificity protein phosphatase | 0.0489 | 0.096 | 0.0911 |
Wolbachia endosymbiont of Brugia malayi | replicative DNA helicase | 0.1289 | 0.2609 | 1 |
Mycobacterium tuberculosis | Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) | 0.008 | 0.0115 | 0.0241 |
Schistosoma mansoni | hypothetical protein | 0.0464 | 0.0906 | 0.3411 |
Toxoplasma gondii | 3-ketoacyl-(acyl-carrier-protein) reductase | 0.008 | 0.0115 | 0.048 |
Treponema pallidum | replicative DNA helicase (dnaB) | 0.1289 | 0.2609 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0128 | 0.0213 | 0.2223 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0092 | 0.014 | 0.0099 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0464 | 0.0906 | 0.0857 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.006 | 0.062 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.