Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0088 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0404 | 0.2348 | 0.2348 |
Schistosoma mansoni | tyrosinase precursor | 0.0404 | 0.2348 | 0.2979 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0634 | 0.072 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0634 | 0.072 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.1211 | 0.7324 | 0.7324 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1645 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1645 | 1 | 1 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0046 | 0.0141 | 0.007 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0052 | 0.018 | 0.0121 |
Onchocerca volvulus | 0.0404 | 0.2348 | 0.3206 | |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0088 | 1 |
Brugia malayi | hypothetical protein | 0.0026 | 0.002 | 0.002 |
Onchocerca volvulus | 0.0046 | 0.0141 | 0.0193 | |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0179 | 0.0967 | 0.1158 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0404 | 0.2348 | 0.2348 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0052 | 0.018 | 0.018 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0126 | 0.0634 | 0.0634 |
Onchocerca volvulus | 0.0404 | 0.2348 | 0.3206 | |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0833 | 0.4995 | 0.6469 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.0858 | 0.1014 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.1211 | 0.7324 | 0.9539 |
Echinococcus granulosus | tar DNA binding protein | 0.0126 | 0.0634 | 0.072 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | 0.0404 | 0.2348 | 0.3206 | |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.002 | 0.002 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1267 | 0.7674 | 1 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0404 | 0.2348 | 0.2348 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0088 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.002 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1645 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0277 | 0.1567 | 0.195 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0046 | 0.0141 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0841 | 0.5043 | 0.5043 |
Brugia malayi | RNA binding protein | 0.0126 | 0.0634 | 0.0634 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.002 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0 | 0.5 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.1211 | 0.7324 | 0.7324 |
Onchocerca volvulus | 0.0404 | 0.2348 | 0.3206 | |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.0141 | 0.0141 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.0858 | 0.1014 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0046 | 0.0141 | 0.007 |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.0141 | 0.0141 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1645 | 1 | 1 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.1211 | 0.7324 | 0.9539 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0404 | 0.2348 | 0.2348 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.0088 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0404 | 0.2348 | 0.2348 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.1211 | 0.7324 | 0.9539 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0046 | 0.0141 | 0.0141 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1267 | 0.7674 | 1 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0052 | 0.018 | 0.0121 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0404 | 0.2348 | 0.2348 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0634 | 0.072 |
Loa Loa (eye worm) | RNA binding protein | 0.0126 | 0.0634 | 0.0634 |
Brugia malayi | TAR-binding protein | 0.0126 | 0.0634 | 0.0634 |
Echinococcus granulosus | geminin | 0.0162 | 0.0858 | 0.1014 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0046 | 0.0141 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.002 | 0.002 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.002 | 0.5 |
Loa Loa (eye worm) | MBCTL1 | 0.0052 | 0.018 | 0.018 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.018 | 0.018 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.1211 | 0.7324 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.002 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0179 | 0.0967 | 0.1158 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0052 | 0.018 | 0.0121 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0141 | 0.0141 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0052 | 0.018 | 0.0121 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0634 | 0.072 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.2348 | 0.2348 |
Echinococcus multilocularis | geminin | 0.0162 | 0.0858 | 0.1014 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0046 | 0.0141 | 0.007 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0052 | 0.018 | 0.0121 |
Echinococcus multilocularis | tar DNA binding protein | 0.0126 | 0.0634 | 0.072 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0404 | 0.2348 | 0.2348 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0046 | 0.0141 | 0.007 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0126 | 0.0634 | 0.0634 |
Loa Loa (eye worm) | TAR-binding protein | 0.0126 | 0.0634 | 0.0634 |
Echinococcus granulosus | microtubule associated protein 2 | 0.1267 | 0.7674 | 1 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0088 | 0.0088 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0046 | 0.0141 | 0.0193 |
Brugia malayi | ShTK domain containing protein | 0.0404 | 0.2348 | 0.2348 |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.2348 | 0.2348 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0404 | 0.2348 | 0.2348 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0046 | 0.0141 | 0.007 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0 | 0.5 |
Schistosoma mansoni | tyrosinase precursor | 0.0404 | 0.2348 | 0.2979 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0634 | 0.072 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.