Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Nischarin | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | nischarin | Get druggable targets OG5_133208 | All targets in OG5_133208 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133208 | All targets in OG5_133208 |
Brugia malayi | hypothetical protein | Get druggable targets OG5_133208 | All targets in OG5_133208 |
Onchocerca volvulus | Nischarin homolog | Get druggable targets OG5_133208 | All targets in OG5_133208 |
Echinococcus granulosus | nischarin | Get druggable targets OG5_133208 | All targets in OG5_133208 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0182 | 0.1895 | 0.1891 |
Schistosoma mansoni | glutaminyl-peptide cyclotransferase-related | 0.0182 | 0.1895 | 0.1895 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0503 | 1 | 1 |
Schistosoma mansoni | nicalin (M28 family) | 0.0182 | 0.1895 | 0.1895 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0182 | 0.1895 | 0.1891 |
Brugia malayi | hypothetical protein | 0.0166 | 0.149 | 0.149 |
Echinococcus multilocularis | nischarin | 0.017 | 0.1586 | 0.1581 |
Mycobacterium ulcerans | hypothetical protein | 0.0182 | 0.1895 | 0.5 |
Brugia malayi | nicalin | 0.0182 | 0.1895 | 0.1895 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0503 | 1 | 1 |
Schistosoma mansoni | NAALADASE L peptidase (M28 family) | 0.0182 | 0.1895 | 0.1895 |
Toxoplasma gondii | hypothetical protein | 0.0182 | 0.1895 | 0.5 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0182 | 0.1895 | 0.1895 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0005 | 0.0005 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0182 | 0.1895 | 0.5 |
Schistosoma mansoni | Fxna peptidase (M28 family) | 0.0182 | 0.1895 | 0.1895 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0182 | 0.1895 | 0.1891 |
Onchocerca volvulus | Nischarin homolog | 0.0166 | 0.1485 | 0.1485 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.149 | 0.149 |
Mycobacterium tuberculosis | Conserved protein | 0.0182 | 0.1895 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0503 | 1 | 1 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0182 | 0.1895 | 0.1895 |
Brugia malayi | FXNA | 0.0182 | 0.1895 | 0.1895 |
Brugia malayi | leucyl aminopeptidase | 0.0182 | 0.1895 | 0.1895 |
Onchocerca volvulus | Fxna peptidase homolog | 0.0182 | 0.1895 | 0.1895 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.1895 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1895 | 0.1895 |
Brugia malayi | Peroxidasin | 0.0107 | 0.0005 | 0.0005 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0503 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.1895 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1895 | 0.1895 |
Loa Loa (eye worm) | hypothetical protein | 0.0503 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0107 | 0.0005 | 0.0005 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0182 | 0.1895 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0182 | 0.1895 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1895 | 0.1895 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0182 | 0.1895 | 0.5 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0182 | 0.1895 | 0.1895 |
Leishmania major | glutaminyl cyclase, putative | 0.0182 | 0.1895 | 0.5 |
Onchocerca volvulus | 0.0182 | 0.1895 | 0.1895 | |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.1895 | 0.1895 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0182 | 0.1895 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0182 | 0.1895 | 0.5 |
Echinococcus granulosus | nischarin | 0.017 | 0.1586 | 0.1581 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0182 | 0.1895 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0182 | 0.1895 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0182 | 0.1895 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0107 | 0.0005 | 0.0005 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0182 | 0.1895 | 0.1891 |
Echinococcus granulosus | endoplasmic reticulum metallopeptidase 1 | 0.0182 | 0.1895 | 0.1891 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7749 nM | Inhibition of Sprague-Dawley rat imidazoline I1 receptor | ChEMBL. | 21159515 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.