Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | NPC1-like 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | hypothetical protein | 0.0092 | 0.0649 | 0.5 |
Leishmania major | glutaminyl cyclase, putative | 0.0092 | 0.0649 | 0.5 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0092 | 0.0649 | 0.0649 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0092 | 0.0649 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0649 | 0.0572 |
Schistosoma mansoni | glutaminyl cyclase (M28 family) | 0.0578 | 1 | 1 |
Mycobacterium tuberculosis | Probable lipoprotein aminopeptidase LpqL | 0.0092 | 0.0649 | 0.5 |
Onchocerca volvulus | Glutaminyl cyclase homolog | 0.0578 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0092 | 0.0649 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0649 | 0.0572 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0649 | 0.0572 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0119 | 0.1167 | 0.1167 |
Echinococcus multilocularis | endoplasmic reticulum metallopeptidase 1 | 0.0092 | 0.0649 | 0.0649 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0092 | 0.0649 | 0.5 |
Echinococcus multilocularis | glutaminyl peptide cyclotransferase | 0.0578 | 1 | 1 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0092 | 0.0649 | 0.5 |
Mycobacterium ulcerans | lipoprotein aminopeptidase LpqL | 0.0092 | 0.0649 | 0.5 |
Echinococcus multilocularis | expressed conserved protein | 0.0112 | 0.1028 | 0.1028 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1167 | 0.1094 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0119 | 0.1167 | 0.0554 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.017 | 0.2149 | 0.2149 |
Loa Loa (eye worm) | hypothetical protein | 0.0578 | 1 | 1 |
Echinococcus granulosus | glutaminyl peptide cyclotransferase | 0.0578 | 1 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0121 | 0.1203 | 0.0592 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0092 | 0.0649 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0119 | 0.1167 | 0.0554 |
Trichomonas vaginalis | Clan MH, family M28, aminopeptidase S-like metallopeptidase | 0.0092 | 0.0649 | 0.5 |
Trypanosoma brucei | glutaminyl cyclase, putative | 0.0092 | 0.0649 | 0.5 |
Echinococcus granulosus | expressed conserved protein | 0.0112 | 0.1028 | 0.0406 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.017 | 0.2149 | 0.1604 |
Mycobacterium tuberculosis | Conserved protein | 0.0092 | 0.0649 | 0.5 |
Toxoplasma gondii | peptidase, M28 family protein | 0.0092 | 0.0649 | 0.5 |
Echinococcus multilocularis | n acetylated alpha linked acidic dipeptidase 2 | 0.0092 | 0.0649 | 0.0649 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0649 | 0.0572 |
Leishmania major | hypothetical protein, conserved | 0.0092 | 0.0649 | 0.5 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0119 | 0.1167 | 0.5 |
Trypanosoma cruzi | glutaminyl cyclase, putative | 0.0092 | 0.0649 | 0.5 |
Loa Loa (eye worm) | leucyl aminopeptidase | 0.0092 | 0.0649 | 0.0572 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.2 uM | Displacement of [35S](2S,3S,4S,5R,6S)-6-(4-((2S,3R)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-1-(4-(3-(methylsulfonamido)prop-1-ynyl)phenyl)-4-oxoazetidin-2-yl)phenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid from human NCP1L1 expressed in HEK 293 | ChEMBL. | 21030254 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.