Detailed information for compound 1467777

Basic information

Technical information
  • TDR Targets ID: 1467777
  • Name: 2-[(2-furan-2-yl-2-piperidin-1-ylethyl)amino] -1-phenylethanol
  • MW: 314.422 | Formula: C19H26N2O2
  • H donors: 2 H acceptors: 1 LogP: 2.15 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(c1ccccc1)CNCC(c1ccco1)N1CCCCC1
  • InChi: 1S/C19H26N2O2/c22-18(16-8-3-1-4-9-16)15-20-14-17(19-10-7-13-23-19)21-11-5-2-6-12-21/h1,3-4,7-10,13,17-18,20,22H,2,5-6,11-12,14-15H2
  • InChiKey: QKQLDJIRSWQZPF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[2-(2-furyl)-2-(1-piperidyl)ethyl]amino]-1-phenyl-ethanol
  • 2-[[2-(2-furyl)-2-(1-piperidyl)ethyl]amino]-1-phenylethanol
  • 2-[[2-(2-furyl)-2-piperidino-ethyl]amino]-1-phenyl-ethanol
  • 2-[(2-furan-2-yl-2-piperidin-1-yl-ethyl)amino]-1-phenyl-ethanol
  • T5510246

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1283 0.0749 0.2007
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1283 0.0749 0.9111
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0732 0.0396 0.0958
Trichomonas vaginalis PIKK family atypical protein kinase 0.074 0.0401 0.4691
Trichomonas vaginalis PIKK family atypical protein kinase 0.1265 0.0738 0.9821
Trichomonas vaginalis PIKK family atypical protein kinase 0.1265 0.0738 0.9821
Echinococcus multilocularis serine protein kinase ATM 0.0732 0.0396 0.0306
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1324 0.0775 0.9472
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.104 0.0594 0.7626
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.104 0.0594 0.7657
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0684 0.0365 0.0274
Loa Loa (eye worm) phosphatidylinositol 3 0.026 0.0094 0.125
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0489 0.024 0.2238
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0343 0.0147 0.1895
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0489 0.024 0.31
Loa Loa (eye worm) phosphatidylinositol kinase 0.026 0.0094 0.125
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1283 0.0749 0.0662
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1324 0.0775 0.2084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0703 0.0378 0.4334
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0845 0.0469 0.5721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0725 0.0391 0.4543
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.026 0.0094 0.1208
Loa Loa (eye worm) hypothetical protein 0.0684 0.0365 0.4875
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.104 0.0594 0.1544
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1283 0.0749 0.9665
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1324 0.0775 0.0688
Trichomonas vaginalis PIKK family atypical protein kinase 0.1247 0.0726 0.9644
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1265 0.0738 0.9822
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.026 0.0094 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.1265 0.0738 0.9821
Trypanosoma cruzi target of rapamycin kinase 3 0.1265 0.0738 0.1972
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0362 0.0159 0.1018
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0362 0.0159 1
Echinococcus multilocularis Zinc finger, PHD finger 0.0362 0.0159 0.0066
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1245 0.0725 0.1798
Echinococcus granulosus serine protein kinase ATM 0.0732 0.0396 0.0306
Giardia lamblia GTOR 0.1283 0.0749 1
Mycobacterium leprae conserved hypothetical protein 0.026 0.0094 0.5
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0362 0.0159 0.2121
Trichomonas vaginalis PIKK family atypical protein kinase 0.1283 0.0749 1
Loa Loa (eye worm) phosphatidylinositol 3 0.026 0.0094 0.125
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0718 0.0387 0.4478
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0362 0.0159 0.0995
Onchocerca volvulus 0.026 0.0094 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1324 0.0775 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.1224 0.0711 0.1759
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.026 0.0094 0.0058
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0521 0.0261 0.0169
Loa Loa (eye worm) phosphatidylinositol 3 0.026 0.0094 0.125
Loa Loa (eye worm) phosphatidylinositol 3 0.1245 0.0725 0.9675
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0362 0.0159 0.0995
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0732 0.0396 0.5114
Trichomonas vaginalis PIKK family atypical protein kinase 0.1224 0.0711 0.942
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.104 0.0594 0.7626
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0387 0.0175 0.1243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0278 0.0105 0.0178
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0362 0.0159 0.0066
Leishmania major hypothetical protein, conserved 0.5742 0.3606 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1224 0.0711 0.942
Trichomonas vaginalis PIKK family atypical protein kinase 0.1242 0.0723 0.9599
Trichomonas vaginalis PIKK family atypical protein kinase 0.0744 0.0404 0.4736
Loa Loa (eye worm) hypothetical protein 0.078 0.0427 0.57
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.026 0.0094 0.0058
Loa Loa (eye worm) phosphatidylinositol 3 0.0229 0.0074 0.0988
Loa Loa (eye worm) phosphatidylinositol 3 0.1256 0.0732 0.9766
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1324 0.0775 0.0688
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.0735 0.9776
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1283 0.0749 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0703 0.0378 0.3949
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0799 0.0439 0.5264
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0703 0.0378 0.0903
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0489 0.024 0.2238
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0489 0.024 0.0494
Trichomonas vaginalis PIKK family atypical protein kinase 0.1265 0.0738 0.9821
Trichomonas vaginalis PIKK family atypical protein kinase 0.0732 0.0396 0.4619
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0362 0.0159 0.0995
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0362 0.0159 0.0186
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0703 0.0378 0.0287
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0845 0.0469 0.5721
Entamoeba histolytica hypothetical protein 0.0913 0.0512 0.6384
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0289 0.0112 0.0114
Loa Loa (eye worm) phosphatidylinositol 3 0.026 0.0094 0.125
Loa Loa (eye worm) hypothetical protein 0.0473 0.023 0.3071
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1383 0.0813 0.0726
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.026 0.0094 0.0058
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0362 0.0159 0.0252
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.0735 0.9776
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0703 0.0378 0.0287
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1283 0.0749 1
Trichomonas vaginalis conserved hypothetical protein 0.078 0.0427 0.5086
Trichomonas vaginalis PIKK family atypical protein kinase 0.1242 0.0723 0.9598
Trichomonas vaginalis PIKK family atypical protein kinase 0.0444 0.0212 0.1798
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.0735 0.9776
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0732 0.0396 0.4619
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0362 0.0159 0.0066
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1283 0.0749 0.1867
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0362 0.0159 0.0995
Trichomonas vaginalis PIKK family atypical protein kinase 0.1242 0.0723 0.9599
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1383 0.0813 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0362 0.0159 0.0186
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0362 0.0159 0.0907
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0362 0.0159 0.0995
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1283 0.0749 0.2007
Trichomonas vaginalis PIKK family atypical protein kinase 0.1283 0.0749 1
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0296 0.0117 0.0356
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0362 0.0159 0.205
Trichomonas vaginalis PIKK family atypical protein kinase 0.1247 0.0726 0.9644
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0521 0.0261 0.0169
Loa Loa (eye worm) hypothetical protein 0.026 0.0094 0.125
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0557 0.0284 0.2901
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0489 0.024 0.2238
Trichomonas vaginalis PIKK family atypical protein kinase 0.1242 0.0723 0.9599
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0913 0.0512 0.6384
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1324 0.0775 0.2084
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0362 0.0159 0.0066
Trypanosoma cruzi hypothetical protein, conserved 0.5483 0.3439 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.0735 0.9776
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0362 0.0159 0.0995
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.104 0.0594 0.7626
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0725 0.0391 0.4543
Loa Loa (eye worm) hypothetical protein 0.0703 0.0378 0.5042
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1265 0.0738 0.1834
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.104 0.0594 0.1544
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0362 0.0159 0.0907
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.026 0.0094 0.1208
Trichomonas vaginalis conserved hypothetical protein 0.0521 0.0261 0.2549
Trichomonas vaginalis PIKK family atypical protein kinase 0.1224 0.0711 0.942
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1283 0.0749 0.0662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0821 0.0453 0.5487
Leishmania major phosphatidylinositol kinase related protein, putative 0.0289 0.0112 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.1224 0.0711 0.942
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.1383 0.0813 0.0726
Toxoplasma gondii non-specific serine/threonine protein kinase 0.078 0.0427 0.5202
Trichomonas vaginalis PIKK family atypical protein kinase 0.1242 0.0723 0.9599
Onchocerca volvulus 0.026 0.0094 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1242 0.0723 0.9598
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0489 0.024 0.2238
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0362 0.0159 0.1018
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1245 0.0725 0.9628
Toxoplasma gondii FATC domain-containing protein 0.0732 0.0396 0.4724
Mycobacterium tuberculosis Conserved hypothetical protein 0.026 0.0094 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0489 0.024 0.2238
Loa Loa (eye worm) hypothetical protein 0.0521 0.0261 0.348
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.5725 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.104 0.0594 0.7626
Trichomonas vaginalis PIKK family atypical protein kinase 0.1242 0.0723 0.9598
Trichomonas vaginalis PIKK family atypical protein kinase 0.1265 0.0738 0.9821
Trichomonas vaginalis PIKK family atypical protein kinase 0.1224 0.0711 0.942
Trichomonas vaginalis PIKK family atypical protein kinase 0.1245 0.0725 0.9628
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0473 0.023 0.0464
Loa Loa (eye worm) phosphatidylinositol 3 0.1283 0.0749 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0781 0.0427 0.509
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0489 0.024 0.2039
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.026 0.0094 0.1208
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.0735 0.9776
Trichomonas vaginalis conserved hypothetical protein 0.0444 0.0212 0.1798
Brugia malayi FAT domain containing protein 0.0521 0.0261 0.3364
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0703 0.0378 0.4873
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.0735 0.9776
Loa Loa (eye worm) hypothetical protein 0.0357 0.0156 0.2078
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0732 0.0396 0.4208
Entamoeba histolytica hypothetical protein 0.0732 0.0396 0.4619
Trichomonas vaginalis PIKK family atypical protein kinase 0.126 0.0735 0.9776
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0362 0.0159 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1283 0.0749 0.1867
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0684 0.0365 0.0274
Trichomonas vaginalis PIKK family atypical protein kinase 0.0763 0.0416 0.4914
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1283 0.0749 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0684 0.0365 0.4712
Trichomonas vaginalis PIKK family atypical protein kinase 0.074 0.0401 0.4691
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0489 0.024 0.2238
Toxoplasma gondii target of rapamycin (TOR), putative 0.126 0.0735 1
Entamoeba histolytica protein kinase rad3, putative 0.0703 0.0378 0.4334
Trichomonas vaginalis PIKK family atypical protein kinase 0.074 0.0401 0.4691
Trichomonas vaginalis PIKK family atypical protein kinase 0.1283 0.0749 1
Schistosoma mansoni hypothetical protein 0.0521 0.0261 0.2322
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1283 0.0749 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0362 0.0159 0.0252

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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