Detailed information for compound 1470986

Basic information

Technical information
  • TDR Targets ID: 1470986
  • Name: 1-(2-tert-butylphenoxy)-3-(2,6-dimethylmorpho lin-4-yl)propan-2-ol
  • MW: 321.454 | Formula: C19H31NO3
  • H donors: 1 H acceptors: 1 LogP: 3.48 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(CN1CC(C)OC(C1)C)COc1ccccc1C(C)(C)C
  • InChi: 1S/C19H31NO3/c1-14-10-20(11-15(2)23-14)12-16(21)13-22-18-9-7-6-8-17(18)19(3,4)5/h6-9,14-16,21H,10-13H2,1-5H3
  • InChiKey: HEIQUICBMLVKRZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2-tert-butylphenoxy)-3-(2,6-dimethyl-4-morpholinyl)propan-2-ol
  • CBMicro_036755
  • CDS1_005011
  • DivK1c_006051
  • Oprea1_520725
  • Oprea1_380122

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.004 0.0292 0.0292
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0016 0.0016
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.004 0.0292 0.0292
Schistosoma mansoni hypothetical protein 0.0428 0.3974 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.004 0.0292 0.0292
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0428 0.3974 1
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0146 0.1296 0.1296
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.0255 0.0255
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0818 0.7665 0.7665
Schistosoma mansoni hypothetical protein 0.0146 0.1296 0.3263
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0152 0.1359 0.5
Loa Loa (eye worm) TK protein kinase 0.0036 0.0255 0.0604
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0152 0.1359 0.5
Schistosoma mansoni hypothetical protein 0.0152 0.1359 0.3419
Brugia malayi nuclear hormone receptor 0.0011 0.0016 0.0041
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0292 0.0292
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0428 0.3974 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.1391 0.3474
Echinococcus granulosus tyrosine protein kinase HCK 0.0032 0.0217 0.0217
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0016 0.0041
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0292 0.0292
Leishmania major hypothetical protein, conserved 0.0152 0.1359 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0016 0.0041
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0146 0.1296 0.3263
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0016 0.0041
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0016 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0428 0.3974 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0016 0.0041
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0152 0.1359 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0152 0.1359 0.5
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0428 0.3974 1
Onchocerca volvulus 0.0428 0.3974 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0016 0.0041
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0016 0.0041
Chlamydia trachomatis SWIB complex protein 0.0428 0.3974 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0016 0.0041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0016 0.0016
Brugia malayi steroid hormone receptor 0.0011 0.0016 0.0041
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0016 0.0041
Leishmania major hypothetical protein, conserved 0.0152 0.1359 0.5
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0036 0.0255 0.0255
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0152 0.1359 0.3419
Brugia malayi SWIB/MDM2 domain containing protein 0.0428 0.3974 1
Echinococcus multilocularis ring and YY1 binding protein 0.0152 0.1359 0.1359
Brugia malayi nuclear receptor NHR-88 0.0011 0.0016 0.0041
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0016 0.0016
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0016 0.0016
Echinococcus granulosus tyrosine protein kinase Lyn 0.004 0.0292 0.0292
Onchocerca volvulus 0.0152 0.1359 0.3393
Brugia malayi brahma associated protein 60 kDa 0.0428 0.3974 1
Trypanosoma cruzi WLM domain containing protein, putative 0.0152 0.1359 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.004 0.0292 0.0292
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0016 0.0016
Brugia malayi protein-tyrosine kinase 0.0036 0.0255 0.0642
Schistosoma mansoni tyrosine kinase 0.004 0.0292 0.0735
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0016 0.0016
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0428 0.3974 0.5
Leishmania major hypothetical protein, conserved 0.0152 0.1359 0.5
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0016 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0016 0.0041
Echinococcus multilocularis SWI:SNF matrix associated 0.0428 0.3974 0.3974
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0016 0.0041
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0152 0.1359 0.3419
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0016 0.0041
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0016 0.0016
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0428 0.3974 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.1359 0.3393
Schistosoma mansoni RNA binding protein 0.0152 0.1359 0.3419
Loa Loa (eye worm) hypothetical protein 0.0152 0.1359 0.3393
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0146 0.1296 0.3235
Onchocerca volvulus 0.0156 0.1391 0.3474
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0152 0.1359 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0016 0.0041
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.004 0.0292 0.0292
Schistosoma mansoni hypothetical protein 0.0146 0.1296 0.3263
Echinococcus multilocularis tyrosine protein kinase Src64B 0.004 0.0292 0.0292
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0292 0.0292
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0146 0.1296 0.3263
Loa Loa (eye worm) hypothetical protein 0.0152 0.1359 0.3393
Echinococcus granulosus zinc finger protein Ran binding 0.0152 0.1359 0.1359
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0152 0.1359 0.5
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0016 0.0041
Echinococcus multilocularis zinc finger protein Ran binding 0.0152 0.1359 0.1359
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0035 0.0245 0.0245
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0016 0.0041
Echinococcus granulosus ring and YY1 binding protein 0.0152 0.1359 0.1359
Trypanosoma cruzi hypothetical protein, conserved 0.0152 0.1359 0.5
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0428 0.3974 1
Schistosoma mansoni brg-1 associated factor 0.0428 0.3974 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0016 0.0016
Loa Loa (eye worm) TK protein kinase 0.0032 0.0217 0.0509
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0818 0.7665 0.7665
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0428 0.3974 0.3974
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0152 0.1359 0.3419
Onchocerca volvulus 0.0152 0.1359 0.3393
Trypanosoma cruzi hypothetical protein, conserved 0.0152 0.1359 0.5
Chlamydia trachomatis DNA topoisomerase I 0.0428 0.3974 0.5
Schistosoma mansoni zinc finger protein 0.0152 0.1359 0.3419
Echinococcus multilocularis tyrosine protein kinase Fgr 0.004 0.0292 0.0292
Trypanosoma cruzi WLM domain containing protein, putative 0.0152 0.1359 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0016 0.0041
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0016 0.0016
Schistosoma mansoni fusion 0.0152 0.1359 0.3419
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0292 0.0292
Echinococcus multilocularis SWI:SNF matrix associated 0.0428 0.3974 0.3974
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0016 0.0016
Onchocerca volvulus 0.0152 0.1359 0.3393
Echinococcus granulosus tyrosine protein kinase Fyn 0.004 0.0292 0.0292
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0152 0.1359 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0016 0.0041
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0016 0.0041
Loa Loa (eye worm) brahma associated protein 0.0428 0.3974 1
Plasmodium vivax hypothetical protein, conserved 0.0428 0.3974 0.5
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0152 0.1359 0.1359
Loa Loa (eye worm) hypothetical protein 0.0152 0.1359 0.3393
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0152 0.1359 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0152 0.1359 0.5
Schistosoma mansoni cellular tumor antigen P53 0.0156 0.1391 0.3501
Schistosoma mansoni tyrosine kinase 0.004 0.0292 0.0735
Brugia malayi YY1-associated factor 2 0.0152 0.1359 0.3419
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0016 0.0016
Echinococcus granulosus tyrosine protein kinase Src42A 0.0035 0.0245 0.0245
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0152 0.1359 0.1359
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0428 0.3974 0.3974
Entamoeba histolytica protein kinase, putative 0.0032 0.0217 0.5
Brugia malayi ecdysteroid receptor 0.0011 0.0016 0.0041
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0016 0.0041
Echinococcus multilocularis tyrosine protein kinase HCK 0.0032 0.0217 0.0217
Schistosoma mansoni apoptosis regulator bax 0.0146 0.1296 0.3263
Loa Loa (eye worm) SRC-1 0.004 0.0292 0.0697
Loa Loa (eye worm) apoptosis regulator protein 0.0146 0.1296 0.3235
Echinococcus granulosus tyrosine protein kinase Fyn 0.004 0.0292 0.0292
Echinococcus multilocularis tumor protein p63 0.1065 1 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0036 0.0255 0.0255
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0016 0.0041
Schistosoma mansoni hypothetical protein 0.0428 0.3974 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0016 0.0016
Leishmania major hypothetical protein, conserved 0.0152 0.1359 0.5
Echinococcus granulosus tyrosine kinase 0.0036 0.0255 0.0255
Schistosoma mansoni TRABID protein (C64 family) 0.0152 0.1359 0.3419
Echinococcus multilocularis tyrosine protein kinase Srms 0.0036 0.0255 0.0255
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0016 0.0041
Onchocerca volvulus 0.0152 0.1359 0.3393
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0016 0.0041
Schistosoma mansoni hypothetical protein 0.0428 0.3974 1
Brugia malayi SRC-1 0.004 0.0292 0.0735
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0146 0.1296 0.3263
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.004 0.0292 0.0292
Echinococcus granulosus SWI:SNF matrix associated 0.0428 0.3974 0.3974
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0152 0.1359 0.3393
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0016 0.0041
Leishmania major hypothetical protein, conserved 0.0152 0.1359 0.5
Echinococcus granulosus Zinc finger RanBP2 type 0.0152 0.1359 0.1359
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0152 0.1359 0.1359
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.004 0.0292 0.0292
Echinococcus multilocularis SWI:SNF matrix associated 0.0428 0.3974 0.3974
Brugia malayi brahma associated protein 60 kDa 0.0428 0.3974 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0292 0.0292
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0016 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0016 0.0041
Schistosoma mansoni coup transcription factor 0.0011 0.0016 0.0041
Trypanosoma brucei hypothetical protein, conserved 0.0152 0.1359 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0016 0.0016
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0016 0.0041
Echinococcus multilocularis tyrosine protein kinase Blk 0.0036 0.0255 0.0255
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0152 0.1359 0.3393
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0146 0.1296 0.1296
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0152 0.1359 0.3419
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0016 0.0041

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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