TDR Targets

Basic information

Technical information

TDR Targets ID: 147132
Name: 2,3-dihydro-1H-benzo[g][1]benzoxepin-4-one
MW: 212.244 | Formula: C14H12O2
H donors: 0 H acceptors: 1 LogP: 3.25 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: O=C1CCCc2c(O1)ccc1c2cccc1
InChi: 1S/C14H12O2/c15-14-7-3-6-12-11-5-2-1-4-10(11)8-9-13(12)16-14/h1-2,4-5,8-9H,3,6-7H2
InChiKey: ROXTWXQUWDZVDI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Saccharomyces cerevisiae	Sir2p	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	chromatin regulatory protein sir2	Get druggable targets OG5_129944	All targets in OG5_129944
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	Get druggable targets OG5_129944	All targets in OG5_129944
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	Get druggable targets OG5_129944	All targets in OG5_129944
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	Get druggable targets OG5_129944	All targets in OG5_129944
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	Get druggable targets OG5_129944	All targets in OG5_129944
Schistosoma japonicum	ko:K01463 sirtuin 1 (silent mating type information regulation 2, homolog) 1 [EC:3.5.1.-], putative	Get druggable targets OG5_129944	All targets in OG5_129944
Brugia malayi	NAD-dependent deacetylase SIRT1	Get druggable targets OG5_129944	All targets in OG5_129944
Giardia lamblia	NAD-dependent histone deacetylase Sir2	Get druggable targets OG5_129944	All targets in OG5_129944
Candida albicans	one of two genes similar to S. cerevisiae SIR2 (YDL042C) NAD+-dependent histone deacetylase	Get druggable targets OG5_129944	All targets in OG5_129944
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	Get druggable targets OG5_129944	All targets in OG5_129944
Candida albicans	one of two genes similar to S. cerevisiae SIR2 (YDL042C) NAD+-dependent histone deacetylase	Get druggable targets OG5_129944	All targets in OG5_129944
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	Get druggable targets OG5_129944	All targets in OG5_129944
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129944	All targets in OG5_129944
Schistosoma japonicum	expressed protein	Get druggable targets OG5_129944	All targets in OG5_129944
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129944	All targets in OG5_129944

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0091	0.3123	0.3123
Brugia malayi	ABC transporter family protein	0.0079	0.2588	0.2588
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0245	1	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0079	0.2588	0.2588
Entamoeba histolytica	P-glycoprotein-5	0.0245	1	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0245	1	1
Entamoeba histolytica	P-glycoprotein-2, putative	0.0245	1	1
Giardia lamblia	ABC transporter, putative	0.0091	0.3123	0.6026
Echinococcus multilocularis	ATP binding cassette sub family B	0.0079	0.2588	0.2588
Entamoeba histolytica	multidrug resistance protein, putative	0.0091	0.3123	0.0874
Trypanosoma brucei	multidrug resistance protein E	0.0091	0.3123	1
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0079	0.2588	0.5
Giardia lamblia	MRP-like ABC transporter	0.0091	0.3123	0.6026
Echinococcus granulosus	ATP binding cassette sub family B	0.0076	0.2464	0.2464
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0079	0.2588	0.5
Echinococcus granulosus	multidrug resistance protein 1	0.0168	0.6586	0.6586
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0245	1	1
Leishmania major	p-glycoprotein e	0.0091	0.3123	0.0722
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0245	1	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0076	0.2464	0.2464
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0245	1	1
Trypanosoma brucei	p-glycoprotein	0.0091	0.3123	1
Entamoeba histolytica	P-glycoprotein 5, putative	0.0245	1	1
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0101	0.3557	0.3557
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0245	1	1
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0245	1	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0331	0.0331
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0168	0.6586	0.6586
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0029	0.0331	0.0331
Echinococcus multilocularis	sodium channel protein	0.0087	0.295	0.295
Leishmania major	ABC-thiol transporter	0.0091	0.3123	0.0722
Loa Loa (eye worm)	hypothetical protein	0.0079	0.2588	0.2588
Schistosoma mansoni	multidrug resistance protein	0.0245	1	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0245	1	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0245	1	1
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0079	0.2588	0.5
Loa Loa (eye worm)	hypothetical protein	0.0245	1	1
Brugia malayi	ABC transporter	0.0076	0.2464	0.2464
Trichomonas vaginalis	ABC transporter, putative	0.0245	1	1
Echinococcus granulosus	multidrug resistance protein 1	0.0168	0.6586	0.6586
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0029	0.0331	0.0331
Plasmodium falciparum	multidrug resistance protein 1	0.0245	1	1
Echinococcus granulosus	multidrug resistance associated protein 7	0.0091	0.3123	0.3123
Loa Loa (eye worm)	hypothetical protein	0.0242	0.9877	0.9877
Echinococcus multilocularis	ATP binding cassette sub family B	0.0242	0.9877	0.9877
Entamoeba histolytica	P-glycoprotein-2	0.0245	1	1
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0079	0.2588	0.5
Schistosoma mansoni	multidrug resistance protein	0.0245	1	1
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0091	0.3123	1
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0086	0.2888	0.2888
Leishmania major	p-glycoprotein	0.0245	1	1
Trichomonas vaginalis	ABC transporter, putative	0.0245	1	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0245	1	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0245	1	1
Brugia malayi	multidrug Resistance Protein family member (mrp-5), putative	0.0079	0.2588	0.2588
Loa Loa (eye worm)	hypothetical protein	0.0091	0.3123	0.3123
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0101	0.3557	0.3557
Trichomonas vaginalis	abcb9, putative	0.0245	1	1
Echinococcus multilocularis	ATP binding cassette sub family B	0.0079	0.2588	0.2588
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0075	0.2414	0.2414
Echinococcus multilocularis	multidrug resistance associated protein 7	0.0091	0.3123	0.3123
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0245	1	1
Leishmania major	pentamidine resistance protein 1	0.0091	0.3123	0.0722
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0091	0.3123	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0076	0.2464	0.2464
Loa Loa (eye worm)	ABC transporter	0.0079	0.2588	0.2588
Schistosoma mansoni	smdr1	0.0079	0.2588	0.2588
Leishmania major	ATP-binding cassette protein subfamily C, member 5, putative	0.0091	0.3123	0.0722
Echinococcus granulosus	ATP binding cassette sub family B	0.0079	0.2588	0.2588
Echinococcus multilocularis	ATP binding cassette sub family B	0.0079	0.2588	0.2588
Schistosoma mansoni	voltage-gated potassium channel	0.0029	0.0331	0.0331
Toxoplasma gondii	hypothetical protein	0.0184	0.7299	0.6356
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0245	1	1
Loa Loa (eye worm)	multidrug resistance protein 3	0.0245	1	1
Schistosoma mansoni	multidrug resistance protein	0.0076	0.2464	0.2464
Loa Loa (eye worm)	hypothetical protein	0.0087	0.2964	0.2964
Loa Loa (eye worm)	hypothetical protein	0.0184	0.7299	0.7299
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0245	1	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0245	1	1
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0101	0.3557	0.3557
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0101	0.3557	0.3557
Trichomonas vaginalis	taga, putative	0.0245	1	1
Echinococcus multilocularis	multidrug resistance protein 1	0.0245	1	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0029	0.0331	0.0331
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0245	1	1
Echinococcus multilocularis	multidrug resistance protein 1	0.0168	0.6586	0.6586
Trichomonas vaginalis	abcb9, putative	0.0245	1	1
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0079	0.2588	0.5
Loa Loa (eye worm)	hypothetical protein	0.0101	0.3557	0.3557
Brugia malayi	ABC transporter family protein	0.0079	0.2588	0.2588
Echinococcus granulosus	ATP binding cassette sub family B	0.0079	0.2588	0.2588
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0245	1	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0086	0.2888	0.2888
Wolbachia endosymbiont of Brugia malayi	ABC-type multidrug transport system, ATPase and permease component	0.0079	0.2588	0.5
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0245	1	1
Echinococcus granulosus	multidrug resistance protein 1	0.0245	1	1
Echinococcus granulosus	multidrug resistance protein 1	0.0245	1	1
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0245	1	1
Schistosoma mansoni	multidrug resistance protein	0.0091	0.3123	0.3123
Schistosoma mansoni	multidrug resistance protein	0.0079	0.2588	0.2588
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0245	1	1
Loa Loa (eye worm)	hypothetical protein	0.0076	0.2464	0.2464
Loa Loa (eye worm)	hypothetical protein	0.0091	0.3123	0.3123
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0245	1	1
Echinococcus multilocularis	ATP binding cassette sub family B	0.0079	0.2588	0.2588
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0101	0.3557	0.3557
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0091	0.3123	0.0874
Brugia malayi	multidrug resistance related protein 1	0.0091	0.3123	0.3123
Echinococcus granulosus	sodium channel protein	0.0087	0.295	0.295
Schistosoma mansoni	multidrug resistance protein	0.0091	0.3123	0.3123
Loa Loa (eye worm)	hypothetical protein	0.0075	0.2413	0.2413
Echinococcus multilocularis	voltage gated potassium channel	0.0029	0.0331	0.0331
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0245	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.0093	0.3219	0.3219
Entamoeba histolytica	ABC transporter, putative	0.0091	0.3123	0.0874
Wolbachia endosymbiont of Brugia malayi	ABC-type protease secretion system, ATPase and permease component, AprD	0.0079	0.2588	0.5
Brugia malayi	ABC transporter transmembrane region family protein	0.0091	0.3123	0.3123
Trypanosoma cruzi	multidrug resistance protein E, putative	0.0091	0.3123	1
Schistosoma mansoni	ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6)	0.0076	0.2464	0.2464
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0087	0.295	0.295
Loa Loa (eye worm)	ABC transporter	0.0079	0.2588	0.2588
Brugia malayi	ABC transporter family protein	0.0079	0.2588	0.2588
Schistosoma mansoni	smdr2	0.0245	1	1
Schistosoma mansoni	multidrug resistance protein	0.0091	0.3123	0.3123
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0091	0.3123	0.0722
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0245	1	1
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0242	0.9877	0.9877
Leishmania major	ATP-binding cassette protein subfamily C, member 2, putative	0.0091	0.3123	0.0722
Schistosoma mansoni	voltage-gated potassium channel	0.0093	0.3219	0.3219
Entamoeba histolytica	P-glycoprotein-2	0.0245	1	1
Leishmania major	ATP-binding cassette protein subfamily C, member 6, putative	0.0091	0.3123	0.0722
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0086	0.2888	0.2888
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0091	0.3123	0.0874
Schistosoma mansoni	chromatin regulatory protein sir2	0.0101	0.3557	0.3557
Brugia malayi	P-glycoprotein-like protein	0.0079	0.2588	0.2588
Trichomonas vaginalis	ABC transporter, putative	0.0245	1	1
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0091	0.3123	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0101	0.3557	0.3557
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0245	1	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0245	1	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0245	1	1
Loa Loa (eye worm)	inward rectifying k channel family protein 1	0.0184	0.7299	0.7299
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0245	1	1
Trichomonas vaginalis	abcb9, putative	0.0245	1	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0245	1	1
Loa Loa (eye worm)	hypothetical protein	0.0088	0.2999	0.2999
Echinococcus multilocularis	multidrug resistance protein 1	0.0245	1	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0086	0.2888	0.2888
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0091	0.3123	0.0874
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.0101	0.3557	1
Entamoeba histolytica	P-glyco protein 6, putative	0.0245	1	1
Echinococcus granulosus	multidrug resistance associated protein 1	0.0091	0.3123	0.3123
Loa Loa (eye worm)	hypothetical protein	0.0245	1	1
Entamoeba histolytica	P-glycoprotein 6, putative	0.0079	0.2588	0.0164
Entamoeba histolytica	hypothetical protein	0.0091	0.3123	0.0874
Loa Loa (eye worm)	ABC transporter	0.0079	0.2588	0.2588
Echinococcus granulosus	multidrug resistance protein 1	0.0245	1	1
Echinococcus granulosus	voltage gated potassium channel	0.0029	0.0331	0.0331
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0245	1	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0245	1	1
Echinococcus multilocularis	multidrug resistance associated protein 1	0.0091	0.3123	0.3123
Giardia lamblia	Multidrug resistance-associated protein 1	0.0091	0.3123	0.6026
Brugia malayi	hypothetical protein	0.0079	0.2588	0.2588
Entamoeba histolytica	P-glycoprotein-1	0.0245	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0076	0.2464	0.2464
Schistosoma mansoni	voltage-gated potassium channel	0.0029	0.0331	0.0331
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0245	1	1
Echinococcus multilocularis		0.0079	0.2588	0.2588
Brugia malayi	ABC transporter family protein	0.0245	1	1
Schistosoma mansoni	ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7)	0.0079	0.2588	0.2588
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0245	1	0.5
Entamoeba histolytica	P-glycoprotein 6, putative	0.0079	0.2588	0.0164
Onchocerca volvulus		0.0245	1	0.5
Leishmania major	ATP-binding cassette protein subfamily C, member 1, putative	0.0091	0.3123	0.0722
Schistosoma mansoni	multidrug resistance protein	0.0091	0.3123	0.3123
Brugia malayi	ABC transporter transmembrane region family protein	0.0076	0.2464	0.2464
Trichomonas vaginalis	ABC transporter, putative	0.0245	1	1
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0101	0.3557	0.3557
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0087	0.295	0.0488
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0076	0.2464	0.2464
Loa Loa (eye worm)	hypothetical protein	0.0184	0.7299	0.7299
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0245	1	1
Schistosoma mansoni	multidrug resistance protein	0.0245	1	1
Mycobacterium ulcerans	component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD	0.0079	0.2588	0.5
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0245	1	1
Giardia lamblia	Multidrug resistance-associated protein 1	0.0088	0.2999	0.4897
Giardia lamblia	Multidrug resistance-associated protein 1	0.0091	0.3123	0.6026
Mycobacterium ulcerans	drugs-transport transmembrane ATP-binding protein ABC transporter	0.0079	0.2588	0.5
Brugia malayi	ABC transporter transmembrane region family protein	0.0079	0.2588	0.2588
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0091	0.3123	1
Plasmodium vivax	multidrug resistance protein 1, putative	0.0245	1	1
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0245	1	1
Loa Loa (eye worm)	hypothetical protein	0.0184	0.7299	0.7299
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0245	1	1
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0091	0.3123	0.0874
Brugia malayi	ABC transporter	0.0079	0.2588	0.2588
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0075	0.2414	0.2414
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0245	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 12 uM	In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysates	ChEMBL.	15115404
IC50 (binding)	= 12 uM	In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysates	ChEMBL.	15115404
Inhibition (binding)	= 0.82 uM	In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysates at 75 uM	ChEMBL.	15115404
Inhibition (binding)	= 0.82 uM	In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysates at 75 uM	ChEMBL.	15115404
MGC (binding)	>= 150 uM	Sirtuin 2 inhibitory activity and was reported as minimum growth-stimulating concentration in S. cerevisiae	ChEMBL.	15115404
MGC (binding)	>= 150 uM	Sirtuin 2 inhibitory activity and was reported as minimum growth-stimulating concentration in S. cerevisiae	ChEMBL.	15115404
T1/2 (ADMET)	= 49.5 hr	Half-life period of the compound was determined	ChEMBL.	15115404

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL313393
PubChem: 11974496

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 147132