TDR Targets

Basic information

Technical information

TDR Targets ID: 1471513
Name: 1-[1-[1-(2-methoxyethyl)tetrazol-5-yl]pentyl] -4-(3-methoxyphenyl)piperazine
MW: 388.507 | Formula: C20H32N6O2
H donors: 0 H acceptors: 3 LogP: 2.61 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCCCC(c1nnnn1CCOC)N1CCN(CC1)c1cccc(c1)OC
InChi: 1S/C20H32N6O2/c1-4-5-9-19(20-21-22-23-26(20)14-15-27-2)25-12-10-24(11-13-25)17-7-6-8-18(16-17)28-3/h6-8,16,19H,4-5,9-15H2,1-3H3
InChiKey: BKLXBFCQMAQAMD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[1-[1-(2-methoxyethyl)-5-tetrazolyl]pentyl]-4-(3-methoxyphenyl)piperazine
1-[1-[1-(2-methoxyethyl)-1,2,3,4-tetrazol-5-yl]pentyl]-4-(3-methoxyphenyl)piperazine
ASN 05553415

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	rab6-interacting	0.0024	0.0385	0.0385
Loa Loa (eye worm)	brahma associated protein	0.02	0.3998	1
Echinococcus multilocularis	RUN	0.0024	0.0385	0.0313
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0011	0.0118	0.0044
Trypanosoma brucei	hypothetical protein, conserved	0.0071	0.1357	0.5
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0009	0.0074	0.0074
Schistosoma mansoni	zinc finger protein	0.0071	0.1357	0.1357
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0024	0.0385	0.0313
Echinococcus granulosus	zinc finger protein Ran binding	0.0071	0.1357	0.1292
Onchocerca volvulus		0.0071	0.1357	0.2689
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0963	0.2178
Echinococcus multilocularis	cpg binding protein	0.0037	0.0648	0.0578
Echinococcus granulosus	Polycystic kidney disease protein	0.0024	0.0385	0.0313
Echinococcus granulosus	cpg binding protein	0.0037	0.0648	0.0578
Echinococcus granulosus	SWI:SNF matrix associated	0.02	0.3998	0.3953
Echinococcus multilocularis	dnaJ subfamily B	0.0494	1	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0011	0.0118	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1357	0.3193
Trichomonas vaginalis	conserved hypothetical protein	0.02	0.3998	1
Echinococcus multilocularis	SWI:SNF matrix associated	0.02	0.3998	0.3953
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0385	0.0689
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.1357	0.5
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0067	0.1262	0.1196
Brugia malayi	hypothetical protein	0.0024	0.0385	0.0696
Chlamydia trachomatis	SWIB complex protein	0.02	0.3998	0.5
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0071	0.1357	0.0416
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.02	0.3998	1
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.02	0.3998	0.3953
Schistosoma mansoni	hypothetical protein	0.0071	0.1357	0.1357
Echinococcus granulosus	lipoxygenase domain containing protein	0.0024	0.0385	0.0313
Schistosoma mansoni	rab6-interacting	0.0024	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0385	0.0689
Echinococcus granulosus	lipoxygenase domain containing protein	0.0024	0.0385	0.0313
Schistosoma mansoni	lipoxygenase	0.0067	0.1262	0.1262
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.02	0.3998	1
Brugia malayi	Doublecortin family protein	0.0024	0.0385	0.0696
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.02	0.3998	1
Brugia malayi	CXXC zinc finger family protein	0.0035	0.0608	0.1269
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0071	0.1357	0.1292
Toxoplasma gondii	ran binding protein	0.0071	0.1357	0.0416
Echinococcus granulosus	Zinc finger RanBP2 type	0.0071	0.1357	0.1292
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0071	0.1357	0.1292
Onchocerca volvulus		0.0052	0.0963	0.1599
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1357	0.3193
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0071	0.1357	0.5
Onchocerca volvulus		0.0071	0.1357	0.2689
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1357	0.3193
Schistosoma mansoni	TRABID protein (C64 family)	0.0071	0.1357	0.1357
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0067	0.1262	0.1196
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.1357	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1357	0.3193
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0071	0.1357	0.3198
Schistosoma mansoni	lipoxygenase	0.0024	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1357	0.3193
Brugia malayi	YY1-associated factor 2	0.0071	0.1357	0.3198
Leishmania major	hypothetical protein, conserved	0.0071	0.1357	0.5
Trypanosoma cruzi	WLM domain containing protein, putative	0.0071	0.1357	0.5
Schistosoma mansoni	cellular tumor antigen P53	0.0052	0.0963	0.0963
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0071	0.1357	0.5
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.02	0.3998	0.3953
Schistosoma mansoni	hypothetical protein	0.0494	1	1
Echinococcus multilocularis	SWI:SNF matrix associated	0.02	0.3998	0.3953
Schistosoma mansoni	hypothetical protein	0.02	0.3998	0.3998
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0035	0.0608	0.1262
Schistosoma mansoni	cpg binding protein	0.0037	0.0648	0.0648
Schistosoma mansoni	hypothetical protein	0.02	0.3998	0.3998
Echinococcus multilocularis	SWI:SNF matrix associated	0.02	0.3998	0.3953
Trypanosoma cruzi	hypothetical protein, conserved	0.0071	0.1357	0.5
Echinococcus granulosus	RUN	0.0024	0.0385	0.0313
Loa Loa (eye worm)	doublecortin family protein	0.0024	0.0385	0.0689
Echinococcus multilocularis	zinc finger protein Ran binding	0.0071	0.1357	0.1292
Trypanosoma brucei	hypothetical protein, conserved	0.0071	0.1357	0.5
Onchocerca volvulus		0.0071	0.1357	0.2689
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.02	0.3998	1
Schistosoma mansoni	cpg binding protein	0.0035	0.0608	0.0608
Brugia malayi	hypothetical protein	0.0024	0.0385	0.0696
Trypanosoma cruzi	WLM domain containing protein, putative	0.0071	0.1357	0.5
Leishmania major	hypothetical protein, conserved	0.0071	0.1357	0.5
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.02	0.3998	1
Onchocerca volvulus		0.0035	0.0608	0.0615
Onchocerca volvulus		0.02	0.3998	1
Echinococcus granulosus	ring and YY1 binding protein	0.0071	0.1357	0.1292
Brugia malayi	brahma associated protein 60 kDa	0.02	0.3998	1
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0071	0.1357	0.2689
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0071	0.1357	0.2689
Schistosoma mansoni	loxhd1	0.0024	0.0385	0.0385
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0071	0.1357	0.5
Leishmania major	hypothetical protein, conserved	0.0071	0.1357	0.5
Echinococcus multilocularis	tumor protein p63	0.0356	0.7171	0.715
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0071	0.1357	0.5
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0024	0.0385	0.0313
Schistosoma mansoni	cpg binding protein	0.0037	0.0648	0.0648
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0071	0.1357	0.1292
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0071	0.1357	0.5
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0071	0.1357	0.3198
Schistosoma mansoni	fusion	0.0071	0.1357	0.1357
Plasmodium vivax	hypothetical protein, conserved	0.02	0.3998	1
Echinococcus granulosus	tumor protein p63	0.0356	0.7171	0.715
Brugia malayi	brahma associated protein 60 kDa	0.02	0.3998	1
Leishmania major	hypothetical protein, conserved	0.0071	0.1357	0.5
Schistosoma mansoni	polycystin 1-related	0.0024	0.0385	0.0385
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0071	0.1357	0.5
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.02	0.3998	1
Schistosoma mansoni	hypothetical protein	0.02	0.3998	0.3998
Echinococcus multilocularis	ring and YY1 binding protein	0.0071	0.1357	0.1292
Leishmania major	hypothetical protein, conserved	0.0071	0.1357	0.5
Echinococcus multilocularis	Polycystic kidney disease protein	0.0024	0.0385	0.0313
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0071	0.1357	0.3198
Schistosoma mansoni	RNA binding protein	0.0071	0.1357	0.1357
Brugia malayi	SWIB/MDM2 domain containing protein	0.02	0.3998	1
Schistosoma mansoni	brg-1 associated factor	0.02	0.3998	0.3998
Chlamydia trachomatis	DNA topoisomerase I	0.02	0.3998	0.5
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0071	0.1357	0.5
Schistosoma mansoni	hypothetical protein	0.0024	0.0385	0.0385
Onchocerca volvulus		0.0071	0.1357	0.2689
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0071	0.1357	0.3198
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.1403	0.1403

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1623727

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1471513