Detailed information for compound 1472507

Basic information

Technical information
  • TDR Targets ID: 1472507
  • Name: N-phenyl-5,6-dihydro-4H-1,3-thiazin-2-amine
  • MW: 192.281 | Formula: C10H12N2S
  • H donors: 1 H acceptors: 0 LogP: 2.08 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)NC1=NCCCS1
  • InChi: 1S/C10H12N2S/c1-2-5-9(6-3-1)12-10-11-7-4-8-13-10/h1-3,5-6H,4,7-8H2,(H,11,12)
  • InChiKey: ITMNZMYUHMBOMN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5,6-dihydro-4H-1,3-thiazin-2-yl-phenyl-amine
  • N-(3,4,5,6-Tetrahydro-1,3-thiazin-2-ylidene)aniline
  • IDI1_008637
  • IFLab1_000418
  • STOCK2S-27516
  • EU-0080990
  • 2-Phenylamino-5,6(4H)dihydro-1,3-thiazine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii peptidase, M28 family protein 0.0058 0.0391 0.5
Schistosoma mansoni hypothetical protein 0.0051 0.0175 0.0175
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0175 0.0175
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.0058 0.0391 0.0391
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0175 0.0175
Mycobacterium ulcerans lipoprotein aminopeptidase LpqL 0.0058 0.0391 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0161 0.3636 0.3636
Echinococcus granulosus GPCR family 2 0.0051 0.0175 0.0175
Schistosoma mansoni hypothetical protein 0.011 0.2034 0.2034
Loa Loa (eye worm) leucyl aminopeptidase 0.0058 0.0391 0.0391
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0391 0.5
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0058 0.0391 0.0391
Brugia malayi FXNA 0.0058 0.0391 0.0391
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0175 0.0175
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0147 0.0147
Trypanosoma cruzi glutaminyl cyclase, putative 0.0058 0.0391 1
Schistosoma mansoni glutaminyl cyclase (M28 family) 0.0364 1 1
Leishmania major hypothetical protein, conserved 0.0058 0.0391 1
Mycobacterium tuberculosis Probable lipoprotein aminopeptidase LpqL 0.0058 0.0391 0.5
Schistosoma mansoni NAALADASE L peptidase (M28 family) 0.0058 0.0391 0.0391
Schistosoma mansoni glutaminyl-peptide cyclotransferase-related 0.0058 0.0391 0.0391
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0175 0.0175
Echinococcus multilocularis glutaminyl peptide cyclotransferase 0.0364 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0147 0.0147
Brugia malayi nicalin 0.0058 0.0391 0.0391
Schistosoma mansoni hypothetical protein 0.0051 0.0175 0.0175
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0161 0.3636 0.3636
Trichomonas vaginalis Clan MH, family M28, aminopeptidase S-like metallopeptidase 0.0058 0.0391 0.5
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0058 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0058 0.0391 0.0391
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0161 0.3636 0.3636
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0175 0.0175
Onchocerca volvulus Glutaminyl cyclase homolog 0.0364 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.0147 0.0147
Echinococcus granulosus glutaminyl peptide cyclotransferase 0.0364 1 1
Loa Loa (eye worm) hypothetical protein 0.011 0.2034 0.2034
Brugia malayi leucyl aminopeptidase 0.0058 0.0391 0.0391
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0147 0.0147
Toxoplasma gondii hypothetical protein 0.0058 0.0391 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0391 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.0391 0.0391
Mycobacterium tuberculosis Conserved protein 0.0058 0.0391 0.5
Echinococcus multilocularis GPCR, family 2 0.0051 0.0175 0.0175
Schistosoma mansoni nicalin (M28 family) 0.0058 0.0391 0.0391
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0175 0.0175
Leishmania major glutaminyl cyclase, putative 0.0058 0.0391 1
Loa Loa (eye worm) hypothetical protein 0.0364 1 1
Trypanosoma brucei glutaminyl cyclase, putative 0.0058 0.0391 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0147 0.0147
Schistosoma mansoni hypothetical protein 0.0051 0.0175 0.0175
Mycobacterium ulcerans hypothetical protein 0.0058 0.0391 0.5
Loa Loa (eye worm) hypothetical protein 0.0058 0.0391 0.0391
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0391 0.5
Schistosoma mansoni Fxna peptidase (M28 family) 0.0058 0.0391 0.0391
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0147 0.0147
Echinococcus multilocularis endoplasmic reticulum metallopeptidase 1 0.0058 0.0391 0.0391
Brugia malayi latrophilin 2 splice variant baaae 0.011 0.2034 0.2034
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0051 0.0175 0.0175
Echinococcus granulosus endoplasmic reticulum metallopeptidase 1 0.0058 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0058 0.0391 0.0391
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0147 0.0147
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0147 0.0147
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0147 0.0147
Schistosoma mansoni hypothetical protein 0.0051 0.0175 0.0175
Trypanosoma cruzi glutaminyl cyclase, putative 0.0058 0.0391 1
Loa Loa (eye worm) hypothetical protein 0.0161 0.3636 0.3636

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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