Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3407 | 0.3809 | 1 |
Onchocerca volvulus | 0.0058 | 0.0054 | 0.5 | |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 0.0309 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0014 | 0.0467 |
Treponema pallidum | polypeptide deformylase (def) | 0.893 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0014 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.0054 | 0.1756 |
Mycobacterium ulcerans | peptide deformylase | 0.893 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0151 | 0.4872 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0151 | 0.4872 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.0014 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.893 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0014 | 0.2662 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.893 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.893 | 1 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.893 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.893 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.0309 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0023 | 0.0014 | 0.2662 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3407 | 0.3809 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3407 | 0.3809 | 1 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.3407 | 0.3809 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.0054 | 1 |
Trypanosoma brucei | Peptide deformylase 2 | 0.3407 | 0.3809 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0023 | 0.0014 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 0.0309 | 1 |
Toxoplasma gondii | hypothetical protein | 0.893 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.0054 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0014 | 0.0467 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.0014 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.3407 | 0.3809 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0014 | 0.0467 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0151 | 0.4872 |
Brugia malayi | hypothetical protein | 0.0286 | 0.0309 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3407 | 0.3809 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0014 | 0.0467 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2239 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 1.7783 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.