Detailed information for compound 14824

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 371.389 | Formula: C22H17N3O3
  • H donors: 2 H acceptors: 4 LogP: 3.66 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)NC(=O)c1c(O)c2cccnc2n(c1=O)c1ccccc1
  • InChi: 1S/C22H17N3O3/c1-14-9-11-15(12-10-14)24-21(27)18-19(26)17-8-5-13-23-20(17)25(22(18)28)16-6-3-2-4-7-16/h2-13,26H,1H3,(H,24,27)
  • InChiKey: DDWMZHCMTVCIHJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0088 0.087 0.0855
Entamoeba histolytica ras-1, putative 0.0369 0.5012 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0328
Brugia malayi nuclear hormone receptor family member odr-7 0.0042 0.0181 0.0328
Loa Loa (eye worm) hypothetical protein 0.0088 0.087 0.1708
Loa Loa (eye worm) hypothetical protein 0.0369 0.5012 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0088 0.087 0.1708
Onchocerca volvulus 0.0037 0.011 0.0297
Loa Loa (eye worm) nuclear hormone receptor 0.0042 0.0181 0.0328
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0328
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0042 0.0181 0.0181
Brugia malayi hypothetical protein 0.0047 0.0255 0.0476
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.0255 0.0476
Giardia lamblia Fructose-bisphosphate aldolase 0.0299 0.3985 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3985 0.7873
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0047 0.0255 0.0476
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0207 0.0176
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0207 0.0176
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0088 0.087 0.0855
Brugia malayi Nuclear hormone receptor-like 1 0.0047 0.0255 0.0476
Brugia malayi ecdysone receptor 0.0042 0.0181 0.0328
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0088 0.087 0.087
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.1016 0.4791
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0088 0.087 0.1708
Toxoplasma gondii hypothetical protein 0.005 0.0302 0.1211
Schistosoma mansoni DNA topoisomerase type I 0.0142 0.1667 0.1653
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0207 0.0176
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0088 0.087 0.1708
Brugia malayi Thioredoxin reductase 0.0039 0.0137 0.0241
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.1727 0.3978
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0137 0.0512
Loa Loa (eye worm) hypothetical protein 0.0088 0.087 0.1708
Trypanosoma brucei DNA topoisomerase type IB small subunit 0.0048 0.0271 0.0584
Onchocerca volvulus 0.0042 0.0181 0.0524
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0088 0.087 0.087
Echinococcus granulosus ecdysone induced protein 78C 0.0088 0.087 0.087
Echinococcus multilocularis DNA topoisomerase 1 0.019 0.2372 0.236
Loa Loa (eye worm) nuclear receptor NHR-67 0.0042 0.0181 0.0328
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0088 0.087 0.1708
Brugia malayi nuclear receptor NHR-67 0.0042 0.0181 0.0328
Echinococcus granulosus DNA topoisomerase 1 0.019 0.2372 0.2372
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0088 0.087 0.087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0088 0.087 0.1708
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0088 0.087 0.1708
Echinococcus granulosus dna polymerase kappa 0.0042 0.0181 0.0181
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0088 0.087 0.087
Mycobacterium tuberculosis Probable reductase 0.0088 0.087 0.3997
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3985 0.7873
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.2712 0.5396
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0146 0.1727 0.3978
Trichomonas vaginalis rap1 and, putative 0.0369 0.5012 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0088 0.087 0.1708
Schistosoma mansoni nuclear hormone receptor 0.0088 0.087 0.0855
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0088 0.087 0.0855
Loa Loa (eye worm) glutathione reductase 0.0039 0.0137 0.0241
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0328
Schistosoma mansoni thyroid hormone receptor 0.0088 0.087 0.0855
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0088 0.087 0.1708
Loa Loa (eye worm) hypothetical protein 0.0047 0.0255 0.0476
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0181 0.0164
Loa Loa (eye worm) hypothetical protein 0.0032 0.0031 0.0029
Brugia malayi nuclear receptor RXR 0.0042 0.0181 0.0328
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0042 0.0181 0.0524
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0088 0.087 0.1708
Trypanosoma brucei unspecified product 0.0035 0.0082 0.0124
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.087 0.3997
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0328
Echinococcus granulosus Nuclear hormone receptor HR96 0.0042 0.0181 0.0181
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0042 0.0181 0.0164
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0047 0.0255 0.0238
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0181 0.0164
Loa Loa (eye worm) hypothetical protein 0.0047 0.0255 0.0476
Onchocerca volvulus 0.0088 0.087 0.2726
Schistosoma mansoni thyroid hormone receptor 0.0088 0.087 0.0855
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3985 0.7873
Schistosoma mansoni RAR-like nuclear receptor 0.0088 0.087 0.0855
Echinococcus granulosus thyroid hormone receptor alpha 0.0042 0.0181 0.0181
Treponema pallidum fructose-bisphosphate aldolase 0.0299 0.3985 0.5
Trichomonas vaginalis GTP-binding protein rit, putative 0.0369 0.5012 1
Brugia malayi hypothetical protein 0.0047 0.0255 0.0476
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0137 0.0241
Brugia malayi Nuclear hormone receptor E75 0.0042 0.0181 0.0328
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0088 0.087 0.0855
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0181 0.0365
Brugia malayi nuclear receptor RXR 0.0047 0.0255 0.0476
Trypanosoma cruzi DNA topoisomerase type IB small subunit, putative 0.0048 0.0271 0.0334
Loa Loa (eye worm) hypothetical protein 0.0088 0.087 0.1708
Brugia malayi polk-prov protein 0.0032 0.0031 0.0029
Schistosoma mansoni single-minded 0.005 0.0301 0.0285
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0328
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0181 0.0365
Brugia malayi conserved hypotetical protein 0.0042 0.0181 0.0328
Loa Loa (eye worm) hypothetical protein 0.0088 0.087 0.1708
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0047 0.0255 0.0238
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0146 0.1727 0.4134
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0146 0.1724 0.8675
Echinococcus granulosus single minded 2 0.0037 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0167 0.2033 0.4036
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3985 0.7873
Brugia malayi PAS domain containing protein 0.005 0.0301 0.0569
Loa Loa (eye worm) hypothetical protein 0.0047 0.0255 0.0476
Leishmania major DNA topoisomerase IB, large subunit 0.0142 0.1667 0.383
Brugia malayi nuclear receptor NHR-88 0.0088 0.087 0.1708
Brugia malayi Pre-SET motif family protein 0.0213 0.2712 0.5396
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0181 0.0164
Brugia malayi Ras protein let-60 0.0369 0.5012 1
Entamoeba histolytica Ras family GTPase 0.0369 0.5012 1
Schistosoma mansoni nuclear receptor nhr-48 0.0042 0.0181 0.0164
Brugia malayi Steroid receptor seven-up type 2 0.0088 0.087 0.1708
Trichomonas vaginalis dexras1, putative 0.0369 0.5012 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0088 0.087 0.1708
Brugia malayi DNA topoisomerase I 0.019 0.2372 0.4716
Loa Loa (eye worm) hypothetical protein 0.0047 0.0255 0.0476
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0328
Brugia malayi bHLH-PAS transcription factor 0.0037 0.011 0.0186
Brugia malayi hypothetical protein 0.0042 0.0181 0.0328
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0328
Onchocerca volvulus Bile acid receptor homolog 0.0088 0.087 0.2726
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3985 0.7873
Loa Loa (eye worm) steroid hormone receptor 0.0088 0.087 0.1708
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0088 0.087 0.0855
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3985 0.7873
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0088 0.087 0.1708
Brugia malayi tailless protein 0.0042 0.0181 0.0328
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.4132 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0088 0.087 0.087
Toxoplasma gondii thioredoxin reductase 0.0039 0.0137 0.0512
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.0142 0.1667 0.383
Trichomonas vaginalis set domain proteins, putative 0.0243 0.3147 0.6139
Echinococcus granulosus ras gtpase 0.0369 0.5012 0.5012
Brugia malayi hypothetical protein 0.0042 0.0181 0.0328
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.0142 0.1667 0.3989
Loa Loa (eye worm) hypoxia-induced factor 1 0.0154 0.1842 0.3654
Plasmodium falciparum topoisomerase I 0.019 0.2372 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0042 0.0181 0.0181
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0181 0.0109
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0042 0.0181 0.0328
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0181 0.0109
Loa Loa (eye worm) hypothetical protein 0.0088 0.087 0.1708
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.087 0.3997
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.1016 0.4791
Brugia malayi orphan nuclear receptor NR2E1 0.0042 0.0181 0.0328
Schistosoma mansoni coup transcription factor 0.0088 0.087 0.0855
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0181 0.0365
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0088 0.087 0.0855
Onchocerca volvulus 0.0243 0.3147 1
Trichomonas vaginalis rheb, putative 0.0369 0.5012 1
Brugia malayi hypothetical protein 0.0167 0.2033 0.4036
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0088 0.087 0.087
Leishmania major DNA topoisomerase type IB small subunit 0.0048 0.0271 0.0334
Echinococcus granulosus FTZ F1 alpha 0.0088 0.087 0.087
Brugia malayi steroid hormone receptor 0.0088 0.087 0.1708
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0088 0.087 0.1708
Loa Loa (eye worm) DR-78 0.0042 0.0181 0.0328
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0042 0.0181 0.0164
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0181 0.0109
Brugia malayi Ras-related protein R-Ras2 0.0369 0.5012 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0181 0.0365
Trichomonas vaginalis ras-dva small GTPase, putative 0.0369 0.5012 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0088 0.087 0.1708
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0181 0.0181
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0088 0.087 0.0855
Brugia malayi nuclear hormone receptor 0.0042 0.0181 0.0328
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0328
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0146 0.1724 1
Echinococcus multilocularis microtubule associated protein 2 0.0707 1 1
Brugia malayi glutathione reductase 0.0039 0.0137 0.0241
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0088 0.087 0.1708
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0047 0.0255 0.0255
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.1016 0.4791
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.087 0.3997
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0088 0.087 0.0855
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0088 0.087 0.1708
Trichomonas vaginalis ral, putative 0.0369 0.5012 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0088 0.087 0.2726
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0088 0.087 0.087
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.011 0.0093
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.1971 1
Brugia malayi nuclear hormone receptor 0.0088 0.087 0.1708
Echinococcus multilocularis ecdysone induced protein 78C 0.0088 0.087 0.0855
Leishmania major mitochondrial DNA polymerase beta 0.0309 0.4132 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0017 0.0017
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0042 0.0181 0.0164
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0146 0.1724 0.8655
Schistosoma mansoni DNA topoisomerase type I 0.0142 0.1667 0.1653
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.1016 0.1705
Onchocerca volvulus 0.0042 0.0181 0.0524
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0309 0.4132 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0042 0.0181 0.0164
Plasmodium vivax glutathione reductase, putative 0.0039 0.0137 0.0512
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0181 0.0365
Trypanosoma brucei trypanothione reductase 0.0039 0.0137 0.0258
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0328
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0181 0.0365
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0088 0.087 0.0855
Loa Loa (eye worm) hypothetical protein 0.0047 0.0255 0.0476
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0042 0.0181 0.0164
Loa Loa (eye worm) hypothetical protein 0.0088 0.087 0.1708
Loa Loa (eye worm) DNA topoisomerase I 0.019 0.2372 0.4716
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0348 0.0527
Schistosoma mansoni retinoic acid receptor RXR 0.0088 0.087 0.0855
Schistosoma mansoni zinc finger protein 0.0042 0.0181 0.0164
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0088 0.087 0.0855
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0328
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0328
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0207 0.043
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0042 0.0181 0.0164
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0309 0.4132 1
Brugia malayi ecdysteroid receptor 0.0088 0.087 0.1708
Schistosoma mansoni DNA topoisomerase type I 0.019 0.2372 0.236
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0088 0.087 0.1708
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0328
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0181 0.0365
Toxoplasma gondii DNA topoisomerase I, putative 0.019 0.2372 1
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0181 0.0165
Loa Loa (eye worm) hypothetical protein 0.0042 0.0181 0.0328
Echinococcus multilocularis thyroid hormone receptor alpha 0.0088 0.087 0.0855
Echinococcus multilocularis nuclear receptor nhr 48 0.0042 0.0181 0.0164
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0181 0.0383
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0088 0.087 0.1708
Loa Loa (eye worm) hypothetical protein 0.0088 0.087 0.1708
Echinococcus multilocularis ras gtpase 0.0369 0.5012 0.5004
Entamoeba histolytica Ras family GTPase 0.0369 0.5012 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0088 0.087 0.1708
Brugia malayi nuclear hormone receptor family member nhr-6 0.0042 0.0181 0.0328
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0088 0.087 0.1708
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0181 0.0383
Brugia malayi Nuclear hormone receptor E75 0.0042 0.0181 0.0328
Schistosoma mansoni nuclear receptor 0.0042 0.0181 0.0164
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0301 0.0285
Brugia malayi Nuclear hormone receptor-like 1 0.0088 0.087 0.1708
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0145 0.0128
Echinococcus granulosus nuclear receptor nhr 48 0.0042 0.0181 0.0181
Echinococcus multilocularis FTZ F1 alpha 0.0088 0.087 0.0855
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0088 0.087 0.0855
Trypanosoma brucei DNA polymerase IV, putative 0.0035 0.0082 0.0124
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3985 0.7873
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0088 0.087 0.1708
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0145 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0181 0.0365
Mycobacterium ulcerans hypothetical protein 0.0163 0.1971 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0088 0.087 0.0855
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0042 0.0181 0.0524
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0088 0.087 0.0855
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0042 0.0181 0.0328
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.087 0.3997
Brugia malayi hypoxia-induced factor 1 0.0154 0.1842 0.3654
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0181 0.0365
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0047 0.0255 0.0238
Schistosoma mansoni microtubule-associated protein tau 0.0707 1 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0088 0.087 0.2726
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0299 0.3985 0.7873
Loa Loa (eye worm) Ras protein let-60 0.0369 0.5012 1
Plasmodium vivax topoisomerase I, putative 0.019 0.2372 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0181 0.0109
Loa Loa (eye worm) hypothetical protein 0.0088 0.087 0.1708
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0181 0.0365
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0088 0.087 0.1708
Schistosoma mansoni nuclear receptor 0.0042 0.0181 0.0164
Brugia malayi nuclear receptor NHR-88 0.0042 0.0181 0.0328
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0181 0.0365
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.087 0.3997

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = -3.5 % Inhibition of Zymosan-induced rat's paw edema(ZPE) after peroral administration of 100 mg/kg dose. ChEMBL. 1552506
Inhibition (functional) = 2.2 % Inhibition of carrageenan-induced rat's paw edema (CPE) after peroral administration of 100 mg/kg dose. ChEMBL. 1552506
Inhibition (functional) = 21.5 % Compound was tested for the inhibition of rat reversed passive Arthus pleurisy after peroral administration of 100 mg/kg dose at 4.66*10e6 no of cells with 5.72*10e6 cells of control ChEMBL. 1552506
Inhibition (functional) = 22.4 % Compound was tested for the inhibition of rat reversed passive Arthus pleurisy after peroral administration of 100 mg/kg dose at 0.65 mL of exudate volume with 0.84 mL of control (injected intrapleurally) ChEMBL. 1552506
Swelling (functional) = 65 % Antiinflammatory activity of the compound on Zymosan-induced rat's paw edema(ZPE) after peroral administration of 100 mg/kg dose with control swelling of 62.8% ChEMBL. 1552506
Swelling (functional) = 66.6 % Antiinflammatory activity of the compound on Carrageenan rat's paw edema(CPE) after peroral administration of 100 mg/kg dose with control swelling of 68.1% ChEMBL. 1552506

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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